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| 1 | Endoclips vs large or small-volume epinephrine in peptic ulcer recurrent bleeding显示文摘AIM:To compare the recurrent bleeding after endoscopic injection of different epinephrine volumes with hemoclips in patients with bleeding peptic ulcer.METHODS:Between January 2005 and December 2009,150 patients with gastric or duodenal bleeding ulcer with major stigmata of hemorrhage and nonbleeding visible vessel in an ulcer bed(Forrest Ⅱa) were included in the study.Patients were randomized to receive a small-volume epinephrine group(15 to 25 mL injection group;Group 1,n = 50),a large-volume epinephrine group(30 to 40 mL injection group;Group 2,n = 50) and a hemoclip group(Group 3,n = 50).The rate of recurrent bleeding,as the primary outcome,was compared between the groups of patients included in the study.Secondary outcomes compared between the groups were primary hemostasis rate,permanent hemostasis,need for emergency surgery,30 d mortality,bleeding-related deaths,length of hospital stay and transfusion requirements.RESULTS:Initial hemostasis was obtained in all patients.The rate of early recurrent bleeding was 30%(15/50) in the small-volume epinephrine group(Group 1) and 16%(8/50) in the large-volume epinephrine group(Group 2)(P = 0.09).The rate of recurrent bleeding was 4%(2/50) in the hemoclip group(Group 3);the difference was statistically significant with regard to patients treated with either small-volume or large-volume epinephrine solution(P = 0.0005 and P = 0.045,respectively).Duration of hospital stay was significantly shorter among patients treated with hemoclips than among patients treated with epinephrine whereas there were no differences in transfusion requirement or even 30 d mortality between the groups.CONCLUSION:Endoclip is superior to both small and large volume injection of epinephrine in the prevention of recurrent bleeding in patients with peptic ulcer. | Neven Ljubicic Ivan Budimir Alen Biscanin Marko Nikolic Vladimir Supanc Davor Hrabar Tajana Pavic | 2012 | World Journal of Gastroenterology2012，18，18： | 11 |
| 2 | Waveguide miniaturization using uniaxial negative permeability metamaterial 显示文摘 | Hrabar S Bartolic J Sipus Z | 2005 | IEEE Trails Antenna Propagat2005，53，1： | 1 |
| 3 | Stratigraphic sections, bedding sequences and random processes 显示文摘 | Carr D D Horowitz A Hrabar S V | 1966 | Science1966，154，3753： | 1 |
| 4 | Prognosis and clinical characteristics of levels of BMI in the heart failure显示文摘 | Femandez AA Ferrante D Hrabar A | 2005 | Poster Dislay Ⅳ Prognosis2005，，： | 1 |
| 5 | Waveguide miniaturization using uniaxial negative permeability metamaterial显示文摘 | HRABAR S BARTOLIC J SIPUS Z | 2005 | IEEE Transactions on Antennas and Propagation2005，53，1： | 1 |
| 6 | Therapy of malignant liver tumors显示文摘 | Hrabar D | 2003 | Acta Med Croatica2003，57，3： | 1 |
| 7 | The role of endoscopic ultrasound in evaluation of gastric subepithelial lesions显示文摘 | Pavi T Hrabar D Duvnjak M | 2010 | Coll Antropol2010，34，2： | 1 |
| 8 | Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia显示文摘BACKGROUNDGhrelin is an adipokine that plays an important role in energy balance. Expressionof ghrelin and ghrelin receptor has been investigated in different tissues andtumors. Studies regarding expression of ghrelin and ghrelin receptor in colorectaltumors are scarce and no data on expression of ghrelin and its receptor incolorectal adenomas has been published. Ghrelin and ghrelin receptor werehighly expressed in colon carcinoma cells while expression was decreased in lessdifferentiated tumors, presuming that ghrelin might be important in early phasesof tumorigenesis.AIMTo investigate the expression of ghrelin and ghrelin receptor in human colorectaladenomas and adjacent colorectal tissue.METHODSIn this prospective study (conducted from June 2015 until May 2019) we included92 patients (64 male and 28 female) who underwent polypectomy for colorectaladenomas in the Department of Gastroenterology and Hepatology, “Sestre milosrdnice” Clinical Hospital Center in Zagreb, Croatia. After endoscopicremoval of colorectal adenoma, an additional sample of colon mucosa in theproximity of the adenoma was collected for pathohistological analysis. Adenomaswere graded according to the stage of dysplasia, and ghrelin and ghrelin receptorexpression were determined immunohistochemically in both adenoma andadjacent colon tissue using the polyclonal antibody for ghrelin (ab150514,ABCAM Inc, Cambridge, United States) and ghrelin receptor (ab48285, ABCAMInc, Cambridge, United States). Categorical and nominal variables were describedthrough frequencies and proportions and the difference between specific groupswere analyzed with Fisher’s and Fisher-Freeman-Halton’s method respectively.Spearman's rank correlation coefficient was determined for correlation ofexpression of ghrelin and ghrelin receptor in adenoma and adjacent colon tissuewith the grade of adenoma dysplasia.RESULTSAmong 92 patients with colorectal adenoma 43 had adenomas with high-gradedysplasia (46.7%). High expression of ghrelin was 7 times more common in highgradeadenoma compared to low-grade adenomas (13.95% to 2.04%, P = 0.048),while the expression of ghrelin in adjacent colon tissue was low. We found nocorrelation between ghrelin receptor expression in adenoma and adjacent colontissue and the grade of colorectal adenoma dysplasia. The most significantcorrelation was found between ghrelin and ghrelin receptor expression inadenomas with high-grade dysplasia (rho = 0.519, P < 0.001).CONCLUSIONGhrelin and ghrelin receptor are expressed in colorectal adenoma and adjacenttissue with ghrelin expression being more pronounced in high grade dysplasia asa possible consequence of increased local synthesis. | Sanja Stojsavljevic-Shapeski Lucija Virovic-Jukic Davor Tomas Marko Duvnjak Vedran Tomasic Davor Hrabar Dominik Kralj Ivan Budimir Neven Barsic Neven Ljubicic | 2021 | World Journal of Gastrointestinal Surgery2021，13，12： | 1 |
| 9 | Endoscopic nltrasonography in the diagnosis of choledocholithiasis 显示文摘 | Hrabar D Gomerci6 M Duvnjak M | 2009 | Acta Med Croatica2009，63，3： | 1 |
| 10 | Towards understanding thebifunctional hydrodeoxygenation and aqueous phase reforming ofglycerol显示文摘 | Wawrzetz A Peng B Hrabar A | 2010 | Journal of Catalysis2010，269，： | 1 |
| 11 | Synthesis of Methyl Mercaptan from Carbonyl Sulfide over Sulfide K2MoO4/SiO2显示文摘 | Gutiérrez O Y Kaufmann C Hrabar A | 2011 | JCatal2011，280，2： | 1 |
| 12 | Towards understanding the bifunctional hydrodeoxygenation and aqueous phase reforming of glycerol显示文摘 | Wawrzetz A Peng B Hrabar A | | 0，，： | 1 |
| 13 | Gut peptide changes in patients with obstructive jaundice undergoing biliary drainage:A prospective case control study显示文摘BACKGROUND Biliary obstruction is a relatively common condition that affects approximately 5 in 1000 people annually.Malnutrition is very common in patients with biliary obstruction and since it is associated with significant morbidity and mortality,it is important to identify factors and mechanisms involved in its development.AIM To determine the influence of obstructive jaundice on the hormones controlling appetite and nutritive status.METHODS This was a prospective case control study performed in a tertiary center in Zagreb,Croatia.Patients with biliary obstruction undergoing internal biliary drainage from September 2012 until August 2013 were enrolled.After excluding patients who developed procedure related complications or were lost in the follow-up,out of initial 73 patients,55 patients were included in the analysis,including 34 with benign and 21 with malignant disease.Meanwhile,40 non-jaundiced controls were also included.Appetite,nutritional status,and serum ghrelin,cholecystokinin(CCK),interleukin 6(IL-6),and tumor necrosis factorα(TNF-α)were determined at admission,48 h and 28 d after internal biliary drainage.Chi square test was used for categorical variables.Continuous variables were analysed for normality by Kolmogorov-Smirnov test and relevant non-parametric(Mann-Whitney,Kruskal-Wallis,and Friedman)or parametric(t-test and analysis of variance)tests were used.RESULTS Patients with obstructive jaundice were significantly malnourished compared to controls,regardless of disease etiology.Plasma ghrelin and CCK levels were significantly higher in patients with obstructive jaundice.Serum bilirubin concentrations were negatively correlated with ghrelin levels and positively correlated with TNF-α,but had no correlation with CCK concentrations.After internal biliary drainage,a significant improvement of nutritional status was observed although serum concentrations of ghrelin,IL-6,and TNF-α remained significantly elevated even 28 d after the procedure.CCK levels in patients without malnutrition remained elevated 28 d after the procedure,but in patients with malnutrition,CCK levels decreased to levels comparable with those in the control group.We have not established any correlation between appetite and serum levels of ghrelin,CCK,IL-6,and TNF-α before and after biliary drainage.CONCLUSION Possible abnormalities in ghrelin and CCK regulation may be associated with the development ofmalnutrition during the inflammatory response in patients with biliary obstruction. | Tajana Pavic Stipe Pelajic Nina Blazevic Dominik Kralj Milan Milosevic Ivana Mikolasevic Ivan Lerotic Davor Hrabar | 2022 | World Journal of Clinical Cases2022，10，17： | 0 |
| 14 | 线结构异向介质在天线小型化中的应用显示文摘本文综述萨格勒布大学承担的用于波导喇叭天线小型化的线结构ENZ异向介质的理论和实验研究。实现了两个工作在IOGHz的小型化喇叭天线,即嵌入单线ENZ板的喇叭天线和嵌入双线ENZ板的喇叭天线,其长度分别是最佳喇叭的52%和33%。它们的测量增益和全长最佳喇叭非常接近(0.1dB以内),但是带宽比较窄(5%~12%)。最后介绍喇叭天线小型化设计中线介质的简单Drude模型应用的理论研究结果。结果显示只有当导线以90°的角度连接到金属板上时其Drude模型才是精确的。即便如此,初步设计阶段使用Drude模型仍是不错的选择,所需的天线特性可由其他理论优化来实现。 | Silvio Hrabar Davor Bonefacic Damir Muha 刘利娜(译) 袁渊(校) | 2010 | 空载雷达2010，，4： | 0 |
| 15 | A plant-based diet supplemented with Hermetia illucens alone or in combination with poultry by-product meal:one step closer to sustainable aquafeeds for European seabass显示文摘Background:Increasing demand for high-value fish species and pressure on forage fish is challenging aquaculture to ensure sustainable growth by replacing protein sources in aquafeeds with plant and terrestrial animal proteins,without compromising the economic value and quality of the final fish product.In the present study,the effects of a plant protein-based diet(CV),two plant-based diets in which graded amounts of plan protein mixtures were replaced with Hermetia illucens meal alone(VH10)or in combination with poultry by-product meal(PBM)(VH10P30),a fishmeal(FM)diet(CF)and an FM diet supplemented with H.illucens(FH10)on growth performance,gut health and homeostasis of farmed subadult European seabass were tested and compared.Results:Fish fed the VH10 and VH10P30 diets showed the highest specific growth rates and lowest feed conversion ratios among the tested groups.Expectedly,the best preservation of PI morphology was observed in fish fed the CF or FH10 diets,while fish fed the CV diet exhibited significant degenerative changes in the proximal and distal intestines.However,PBM supplementation mitigated these effects and significantly improved all gut morphometric parameters in the VH10P30 group.Partial substitution of the plant mixture with insect meal alone or PBM also induced most BBM genes and activated BBM enzymes,suggesting a beneficial effect on intestinal digestive/absorption functions.Regarding intestinal microbiota,fish fed diets containing H.illucens meal(FH10,VH10,VH10P30)had the highest richness of bacterial communities and abundance of beneficial genera such as Lactobacillus and Bacillus.On the other hand,fish fed CV had the highest microbial diversity but lost a significant component of fish intestinal microbiota,the phylum Bacteroidetes.Finally,skin pigmentation most similar to that of farmed or even wild seabass was also observed in the fish groups fed CF,FH10 or VH10P30.Conclusion:Plant-based diets supplemented with PBM and H.illucens pupae meal have great potential as alternative diets for European seabass,without affecting growth performance,gut homeostasis,or overall fitness.This also highlights the importance of animal proteins in diets of European seabass,as the addition of a small amount of these alternative animal protein sources significantly improved all measured parameters. | vana Lepen Pleić Ivana Bušelić Maria Messina Jerko Hrabar LukaŽuvić Igor Talijančić IvaŽužul Tina Pavelin Ivana Anđelić Jelka Pleadin Jasna Puizina Leon Grubišić Emilio Tibaldiand TanjaŠegvić-Bubić | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 0 |
| 16 | 雄性稻绿蝽对雌性鸣唱反应的物种特异性(英文)显示文摘雌性稻绿蝽的鸣唱开始了在基质中产生的通讯并引起雄性不同的特定反应。在两种自然情况下 ,我们检验了雄性稻绿蝽对N viridula ,Thyantapallidovirens和Thyantacustatoraccerra个体鸣唱刺激反应的物种特异性水平 ,并对反应强度和同种及异种刺激性鸣唱的时间特性进行了相关分析 ,证明雄性求偶鸣唱的发送和震动源的定位是最具物种特异性的反应。然而 ,即便是在这个水平上 ,雄性稻绿蝽不能将同种雌性个体的鸣唱与T .custatoraccera的第二个雄性个体的鸣唱区分开来 ,后者与前者有相似的脉冲持续时间和重复时间值。 | Nika HRABAR Meta VIRANT-DOBERLET Andrej■OKL | 2004 | 动物学报2004，50，4： | 0 |
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