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| 1 | Platinum-group elements for the mantle peridotites in the Dazhuka ophiolite,Tibet,China显示文摘The total PGE amounts of mantle peridotites in the Dazhuka ophiolite, Tibet, are 28.37-50.67 ng/g, slightly higher than those of mantle peridotites in the primitive mantle, and typical ophiolites in the world, and the Alps-type mantle peridotites. The PGE distribution patterns in the Dazhuka mantle peridotites are also different from those of the mantle peridotites of partial melting relict origin. The Dazhuka mantle peridotites have relatively high total PGE amounts and are enriched in Pt, Pd, and Ru. Their PGE distribution patterns belong to the positively inclined-or swallow-type patterns. The PGE distribution patterns in the mantle peridotites of partial melting relict origin belong to the negative-slope patterns or flat patterns. This reflects the unique features of the upper mantle in this region. Relative enrichment in Pt and Pd, as well as in the incompatible elements Cu, Au, Cs, Rb, Ba, Th, U and LREE, indicates that the partial melting-derived relict mantle peridotites in the Dazhuka | YU Henqxiang XIA Bin MEI Houjun GUO Linzhi QI Liang TU Xianglin | 2001 | Chinese Science Bulletin2001，46，3： | 5 |
| 2 | Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis显示文摘Metastasis is the leading cause of cancer-related death.The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous metastasis.Surgery is a common intervention for most primary solid tumors.However,surgical trauma-related systemic inflammation facilitates distant tumor metastasis by increasing the spread and adhesion of tumor cells to vascular endothelial cells(ECs).Currently,there are no effective interventions to prevent distant metastasis.Here,we show that HECTD3 deficiency in ECs significantly reduces tumor metastasis in multiple mouse models.HECTD3 depletion downregulates expression of adhesion molecules,such as VCAM-1,ICAM-1 and E-selectin,in mouse primary ECs and HUVECs stimulated by inflammatory factors and inhibits adhesion of tumor cells to ECs both in vitro and in vivo.We demonstrate that HECTD3 promotes stabilization,nuclear localization and kinase activity of IKKa by ubiquitinating IKKa with K27-and K63-linked polyubiquitin chains at K296,increasing phosphorylation of histone H3 to promote NF-kB target gene transcription.Knockout of HECTD3 in endothelium significantly inhibits tumor cells lung colonization,while conditional knockin promotes that.IKKa kinase inhibitors prevented LPS-induced pulmonary metastasis.These findings reveal the promotional role of the HECTD3-IKKa axis in tumor hematogenous metastasis and providea potential strategy for tumormetastasis prevention. | Fubing Li Huichun Liang Hua You Ji Xiao Houjun Xia Xi Chen Maobo Huang Zhuo Cheng Chuanyu Yang Wenjing Liu Hailin Zhang Li Zeng Yingying Wu Fei Ge Zhen Li Wenhui Zhou Yi Wen Zhongmei Zhou Rong Liu Dewei Jiang Ni Xie Bin Liang Zhenzhen Liu Yanjie Kong Ceshi Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 3 | Phenotype and Function of Monocyte-Derived Dendritic Cells from Chinese Rhesus Macaques显示文摘树枝状的房间(DC ) 在响应病原体连接天生的免疫和获得的免疫起一个枢轴的作用。象中国罗猴猕猴(CRM ) 那样的非人类的首领是为人的疾病的潜在的治疗学的药,疫苗和机制的现出症状之前的潜的学习的有利模型。然而,从 CRM 的导出单核白血球的树枝状的房间(MDDC ) 的 phenotypical 描述没被阐明。从 CRM 的单核白血球在 RPMI-1640 与 GM-CSF 和 IL-4 是有教养的。六天以后,这些房间与典型 dendritical 形态学被区分。CD11c 和 DC 签名高度被表示。不成熟的 MDDC 表示了 CD25, CD80, CD83,中等 CD40, CD86,和高 MHC 的底层。在刺激以后,成熟 MDDC 增加了成熟分子的表示 CD25 和 CD83,象 CD80 那样的 co-stimulatory 分子, CD86 和 CD40,并且保留了 MHC 的高水平。endocytosis 的能力与成熟减少了。成熟 MDDC 有导致 allogeneic T 房间增长并且生产 IL-12 的强壮的能力。在结论,我们第一次从 CRM 描绘了显型和 MDDC 的最终的功能。 | Houjun Xia Hongliang Liu Gaohong Zhang Yongtang Zheng | 2009 | Cellular & Molecular Immunology2009，6，3： | 1 |
| 4 | Geochemistry of basalts :Evidence for formation of Dazhu ophiolite, Tibet (China), in a supra-subduction zone environment 显示文摘 | Xia Bin Yu Hengxiang Mei Houjun | 2003 | Journal of the Geological Society of India2003，61，： | 1 |
| 5 | How sugar instigates macrophages to be evils in tumor显示文摘In a recent issue of the journal Cancer Cell,Shi et al.reported that glucose metabolism remodels pro-tumoral functions of tumor-associated macrophages(TAMs)to support cancer metastasis and chemoresistance.Mechanistically,the consumption of glucose fuels hexosamine biosynthetic pathway(HBP)and enhances O-GlcNAcylation of Cathepsin B in macrophages,which upon secretion disrupts the tumor microenvironment(TME)[1]. | Houjun Xia Youhai H.Chen | 2022 | Cellular & Molecular Immunology2022，19，12： | 0 |
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