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| 1 | Epigenetic and non-epigenetic mode of SIRT1 action during oocyte meiosis progression显示文摘Background: SIRT1 histone deacetylase acts on many epigenetic and non-epigenetic targets. It is thought that SIRT1 is involved in oocyte maturation;therefore, the importance of the ooplasmic SIRT1 pool for the further fate of mature oocytes has been strongly suggested. We hypothesised that SIRT1 plays the role of a signalling molecule in mature oocytes through selected epigenetic and non-epigenetic regulation.Results: We observed SIRT1 re-localisation in mature oocytes and its association with spindle microtubules.In mature oocytes, SIRT1 distribution shows a spindle-like pattern, and spindle-specific SIRT1 action decreasesα-tubulin acetylation. Based on the observation of the histone code in immature and mature oocytes, we suggest that SIRT1 is mostly predestined for an epigenetic mode of action in the germinal vesicles(GVs) of immature oocytes. Accordingly, BML-278-driven trimethylation of lysine K9 in histone H3 in mature oocytes is considered to be a result of GV epigenetic transformation.Conclusions: Taken together, our observations point out the dual spatiotemporal SIRT1 action in oocytes,which can be readily switched from the epigenetic to non-epigenetic mode of action depending on the progress of meiosis. | Jan Nevoral Lukas Landsmann Miriam Stiavnicka Petr Hosek Jiri Moravec Sarka Prokesova Hedvika Rimnacova Eliska Koutna Pavel Klein Kristyna Hoskova Tereza Zalmanova Tereza Fenclova Jaroslav Petr Milena Kralickova | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 2 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 3 | Frequency of represent-ative single nucleotide polymorphisms associated with inflam-matory bowel disease in the Czech Republic and Slovak Re-public 显示文摘 | Hosek J Bartosova L Gregor P | 2008 | Folia Biol (Praha)2008，54，3： | 1 |
| 4 | Natural compound cudraflavone B shows promising ant-iinflammatory properties in vitro 显示文摘 | Hosek J Bartos M Chudik S | 2011 | J Nat Prod2011，74，4： | 1 |
| 5 | A new perspective and analysis for regenera- tive machine tool chatter 显示文摘 | OLGAC N HOSEK M | 1998 | International Journal of Machine Tools & Manufacture1998，38，7： | 1 |
| 6 | Job involvement:Concept and measurement显示文摘 | Saleh S D and Hosek J | 1976 | Academy of Management Journal1976，19，2： | 1 |
| 7 | Job involvement: Comeepts and measurements 显示文摘 | Saleh S D hosek J | 1976 | Academy of Management Journal1976，19，： | 1 |
| 8 | Brooks automation expands control capability of precision industrial robots 显示文摘 | Martin Hosek Timothy Bleigh | 2002 | Industrial Robot2002，29，4： | 1 |
| 9 | Effect of time resolution of meteorological inputs on dynamic thermal rating calculations显示文摘 | HOSEK J MUSILEK P LOZOWSKI E | 2011 | IET Generation Transmission&Distribution2011，5，9： | 1 |
| 10 | TNF-x signalling and inflammation: interactions between old acquaintances显示文摘 | Zelovt H Hosek J | 2013 | Inflamm Res2013，62，7： | 1 |
| 11 | Active Vibra- tion Control of Distributed Systems Using Delayed Resonator with Acceleration Feedback显示文摘 | Olgac N Elmali H Hosek M | 1997 | Journal of Dynamic Systems Measurement and Control1997，119，3： | 1 |
| 12 | Natural compound cudraflavoneB shows promising anti-inflammatory properties in vitro 显示文摘 | Hosek J Bartos M Chudik S | 2011 | J NatProd2011，74，4： | 1 |
| 13 | Micronization of Pharmaceutical Substances in a Spiral Jet Mill显示文摘 | Hosek P | 1999 | Powder Technology1999，104，2： | 1 |
| 14 | An exploration of the down-lowidentity: nongay-identified young African-American men who have sex with men显示文摘 | Martinez J Hosek SG | 2005 | J Nat Med Associat2005，97，8： | 1 |
| 15 | A new perspective and analysis for regenerative machine tool chatter显示文摘 | Nejat Olgac Martin Hosek | 1998 | International Journal of Machine Tools & Manufacture1998，，38： | 1 |
| 16 | Stigma and social barriers to medication adherence with urban youth living with HIV 显示文摘 | Rao D Kekwaletswe TC Hosek S | 2007 | AIDS Care2007，19，1： | 1 |
| 17 | SNMP-based acquisition system for DiffServ parameters显示文摘 | Jiri Hosek Karol Molnar Lukas Rucka Milan Bartl | 2013 | Telecommunication Systems2013，，3： | 1 |
| 18 | Zn( Ⅱ )-cblorido comple- xes of phytohormone kinetin and its derivatives modulate expres- sion of inflammatory mediators in THP-1 cells 显示文摘 | Hosek J Novotnta R Babula P el al | 2013 | PLoS One2013，8，65： | 1 |
| 19 | Job involvement : Concepts and measurements 显示文摘 | Saleh SD Hosek J | 1976 | Academy Management J1976，19，： | 1 |
| 20 | Early diagnosis of necrotizing fasciitis with soft tissue ultrasound显示文摘 | Hosek WT Laeger TC | 2009 | Acad Emerg Med2009，16，10： | 1 |
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