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| 1 | Sorption of Manganese (II) and Chromium (III) Ions from Aqueous Solution Using Water Hyacinth Biomass (Eichhornia crassipes)显示文摘 | T. Tarawou D. Wankasi M. Horsfall Jnr | 2010 | Journal of Environmental Science and Engineering2010，4，11： | 3 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Microbial enzyme systems for lignin degradation and their transcriptional regulation显示文摘Lignocellulosic 生物资源是在自然的最丰富的可更新的资源并且作为最有希望的选择之一收到了可观的注意为能量和某些原料的预备给资源上油。酉分的聚合物木质素是这个生物资源资源的第二很丰富的成分并且被显示了有潜力在降级以后被变换成工业上重要的芳香的化学药品。由于它的化学、结构的性质,然而,它向机械、化学、生物的降级展出高电阻,并且这为完成 lignocellulosic 生物资源的有效变换引起一个主要障碍。在自然,降级木质素的微生物发展了唯一的细胞外的酶系统用激进的调停的氧化反应分解木质素。这些微生物由对象滋养的可获得性,氧集中和温度那样的各种各样的环境刺激作出回应与多重 isozymes 和 isoforms 生产酶的一套不同联合,它被认为在 lignocellulosic 生物资源启用木质素的有效分解。在这评论,我们在场包括在每微生物的一般分子的方面,结构的特征,和系统的差别的微生物引起的 ligninolytic 酶系统的概述。我们也与当前的数据描述基因表示模式和每 ligninolytic 酶的 transcriptional 规定机制。 | Takanori FURUKAWA Fatai Olumide BELLO Louise HORSFALL | 2014 | Frontiers in Biology2014，9，6： | 2 |
| 4 | Cell surface antigen CD109 is a novel member of the ct 2' maeroglobulin/C3, C4, C5 family of thioester-containing proteins 显示文摘 | Lin M Sutherland D R Horsfall W | 2002 | Blood2002，99，5： | 1 |
| 5 | Apolipoprotein D: a novel cellular marker for HGPIN and prostate cancer显示文摘 | Hall RE Horsfall DJ Stahl J | 2004 | Prostate2004，58，2： | 1 |
| 6 | Experiment with liquid mixed culture bacterial in the treatment of municipal wastewater显示文摘 | Horsfall F | 1987 | Divisiono Environmental Chemistry1987，5063，： | 1 |
| 7 | Radiological diagnosis of abductor denervation after hip surgery显示文摘 | Roy BR Binns MS Horsfall H | 2001 | Skeletal Radiol2001，30，2： | 1 |
| 8 | Plant disesease an advavced treatise显示文摘 | Horsfall J G Cowling E B | 1930 | How Disease Dwvelops in Populations Academil Press INC1930，5，： | 1 |
| 9 | Genetic variation underlying common hereditary hyperbilirubinaemia (Gil- bert's syndrome) and respiratory health in the 1946 British birth cohort显示文摘 | Horsfall LJ Hardy R Wong A | 2014 | J Hepatol2014，61，6： | 1 |
| 10 | A new geophysical tiltmeter 显示文摘 | HORSFALL J A C KING G C P | 1978 | Nature1978，274，： | 1 |
| 11 | Apolipoprotein-D:a novelcellular marker for HGPIN and prostate cancer显示文摘 | Hall RE Horsfall DJ Stahl J | 2004 | Prostate2004，58，2： | 1 |
| 12 | Expression of the andro gen receptor and an androgen-responsive protein, apolipoprotein D,in human breast Cancer显示文摘 | Hall RE Aspinall JO Horsfall DJ | 1996 | Br J Cancer1996，74，8： | 1 |
| 13 | A technique of tongue reconstruction following near-total glossectomy显示文摘 | Roberson MS Robinson JM Horsfall RM | 1987 | J Laryngol Otol1987，101，： | 1 |
| 14 | A simple index to predict prognosis independent of axillary node information in breast cancer显示文摘 | Seshadri R Horsfall DJ McCaul K | 1997 | Aust N Z J Surg1997，67，11： | 1 |
| 15 | The measurement of chronic pain and health-related quality of life following inguinal hernia repair: a review of the literature 显示文摘 | van Hanswijck JP Lloyd A Horsfall L | 2008 | Hernia2008，12，6： | 1 |
| 16 | Cardiovascular events as a function of serum bilirubin levels in a large,statin-treated cohort显示文摘 | Horsfall U Nazareth I Petersen I | 2012 | Circulation2012，126，22： | 1 |
| 17 | Identifying and addressing bullying in nursing 显示文摘 | Cleary M Hunt GE Horsfall J | 2010 | Issues Ment Health Nuts2010，31，5： | 1 |
| 18 | Serum bilirubin and risk of respiratory disease and death 显示文摘 | Horsfall LJ Rait G Walters K | 2011 | JAMA2011，305，7： | 1 |
| 19 | Ser- um Bilirubin and Risk of Respiratory Disease and Death显示文摘 | HORSFALL L J RAIT G WALTERS K | 2011 | JaMa2011，，： | 1 |
| 20 | Effect of bioaugmentation on the performance of activated sludge reactors 显示文摘 | Hung Y T Shah D B Horsfall F L | 1987 | ProcessBiochemistry1987，，7： | 1 |
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