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| 1 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 2 | Red meat intake and the risk of endometrial cancer:Metaanalysis of observational studies显示文摘AIM:To evaluate whether red meat intake is related to the risk of endometrial cancer(EC) using meta-analysis.METHODS:We searched Pub Med,EMBASE,and the Cochrane Library up to June 2013,using common keywords related to red meat and EC.Case-control studies and cohort studies comparing the risk of endometrial cancer among categories by the amount of intake were included.Eleven case-control studies and five cohort studies met our criteria.We performed a conventional and a dose-response meta-analysis of case-control studies using the Der Simonian-Laird method for random-effects.For cohort studies we performed a conventional meta-analysis.Publication bias was evaluated using Egger's test.RESULTS:In the meta-analysis of 11 case-control studies including 5419 cases and 12654 controls,higher red meat consumption was associated with an increased risk of EC [summary relative risk(SRR) = 1.43,95%CI:1.15-1.79;I2 = 73.3% comparing extreme intake categories).In a dose-response analysis,for red meat intake of 100 g/d,SRR was 1.84(95%CI:1.64-2.05).In contrast,in the meta-analysis of five prospective studies including a total of 2549 cases among 247746 participants,no significant association between red meat intake and EC risk(SRR = 0.97,95%CI:0.85-1.11;I2 = 4.9% comparing extreme intake categories) was observed.CONCLUSION:Our meta-analysis found a significantlinear association between red meat intake and EC risk based on case-control studies but this was not confirmed in prospective studies. | Woong Ju Na Na Keum Dong Hoon Lee Yun Hwan Kim Seung Cheol Kim Eric L Ding Eunyoung Cho | 2015 | World Journal of Meta-Analysis2015，3，2： | 2 |
| 3 | Clinical evaluation of a rapid immunochromatographic test for the diagnosis of dengue virus infection显示文摘 | Sang C T Hoon L S Cuzzubbo A | 1998 | Clinical and Laboratory Immunology1998，5，3： | 1 |
| 4 | A novel family of mammalian taste receptors显示文摘 | Adler E Hoon M A Mueller K L | 2000 | Cell2000，100，： | 1 |
| 5 | Coding of sweet, bitter, and umami tastes : different receptor cells sharing similar signaling pathways显示文摘 | Zhang Y Hoon M A Chandrashekar J Mueller K L Cook B Wu D | 2003 | Cell2003，112，： | 1 |
| 6 | Reducible poly(amido ethylenimine) directed to enhance RNA interference显示文摘 | HOON JEONG J CHRISTENSEN L V YOCKMAN J W | 2007 | Biomaterials2007，28，10： | 1 |
| 7 | Long-term results in patients after rectosigmoid vaginoplasty显示文摘 | Kwun K S Hoon P J Cheol L K | 2003 | Plast Reconstr Surg2003，112，： | 1 |
| 8 | Vibration-baseddamage detection using statistical process control 显示文摘 | Michael L F Hoon S Charles R F | 2001 | Mechanical Systems and Signal Processing2001，15，4： | 1 |
| 9 | Organizational Citizenship Behavior and Social Loafing :The Role of Personality, Motives, and Contextual Factors显示文摘 | Hoon H Tan T M L | 2008 | The Journal of Psychology2008，142，1： | 1 |
| 10 | Characteriatics of Pt/SrTiO3/Pb(Zr,Ti)O3/SrTiO3 Ferroelectric Gate Oxide Structure 显示文摘 | Sang H Hoon C In Yong L Jeong | 1999 | Thin Solid Films1999，，354： | 1 |
| 11 | Effect of dry and wet milled rice flours on the quality attributes of gluten-free dough and noodles显示文摘 | SOOJUNG H SEUNG M L JAE HOON S | 2013 | Journal of Food Engineer-ing2013，116，： | 1 |
| 12 | A novel fami-ly of mammalian taste receptors显示文摘 | Adler E Hoon M A Mueller K L | 2000 | Cell2000，100，6： | 1 |
| 13 | Neuroimaging in spastieity and movement disorders显示文摘 | Hoon A H Belsito K M Nagae-Poetscher L M | 2003 | J Child Neurol2003，18，1： | 1 |
| 14 | Time reversal active sensing for health monitoring of a composite plate显示文摘 | Hyun Woo Parka Hoon Sohnb Kincho H L | 2007 | Journal of Sound and Vibra- tion2007，302，： | 1 |
| 15 | A novel family of mammalian taste receptors 显示文摘 | Adler E Hoon M A Mueller K L | 2000 | Cell2000，100，6： | 1 |
| 16 | Characteriatics of Pt/SrTiO3/Pb( Zr, Ti)O3/SrTiO3 ferroelectric gate oxide structure 显示文摘 | SANG H HOON C I JEONG Y L | 1999 | Thin Solid Films1999，354，12： | 1 |
| 17 | Postauricular and axillary approach endoscopic neck surgery: a new technique显示文摘 | Kyu E L Hoon Y K Won S P | 2009 | World Journal of Surgery2009，33，4： | 1 |
| 18 | Diffusion tensor imaging in children with periventricular leukomalacia:variability of injuries to white matter tracts显示文摘 | Nagae L M Hoon A H Jr Stashinko E | 2007 | AJNR Am J Neuroradiol2007，28，7： | 1 |
| 19 | Wetland restoration to enhance bio- diversity in urban areas: a comparative analysis显示文摘 | Kwi G K Hoon L Dong H L | 2011 | Landscape and Ecological Engineering2011，1，7： | 1 |
| 20 | T2Rsfunction as bitter taste receptors显示文摘 | Chandrashekar J Mueller K L Hoon M A | 2000 | Cell2000，100，6： | 1 |
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