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| 1 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 2 | Concave Cu-Pd bimetallic nanocrystals: Ligand-based Co-reduction and mechanistic study显示文摘The synthesis of highly uniform alloy nanocrystals with a concave feature is desirable for applications in catalysis but is an arduous task. This article proposes an initiative protocol for the fabrication of novel Cu-Pd alloy nanocrystals, wherein the volume of decylamine (DA) in the reaction system was found to greatly influence the formation of different morphologies, including the tetrahedron (TH), concave tetrahedron (CTH), rhombohedral-tetrapod (RTP), and tetrapod (TP). The alloy structure of the products arises from the coordination interaction between the DA and metal ions, which affects the reduction potential of Cu and Pd species, and thus yields co-reduction. Other reaction parameters, such as the type of ligand, amount of reductant, and temperature, were also altered to study the growth mechanism, yielding consistent conclusions in the diffusion-controlled regime. As a catalyst, 48-nm Cu-Pd concave tetrahedral nanocrystals were highly active for the hydrogenation of 3-nitrostyrene and exhibited 〉99.9% chemoselectivity to C=C instead of-NO2. | Lan Zhang Hongyang Su Mei Sun Youcheng Wang Wenlong Wu Taekyung Yu Jie Zeng | 2015 | Nano Research2015，8，7： | 4 |
| 3 | Hepatitis B virus infection increases the risk of cholangiocarcinoma: A meta‐analysis and systematic review显示文摘 | Min Li Jinzheng Li Peizhi Li Hongyang Li Tianyi Su Rongtao Zhu Jianping Gong | 2012 | Journal of Gastroenterology and Hepatology2012，，10： | 2 |
| 4 | Palladium nanoclusters immobilized on defective nanodiamond-graphene core-shell supports for semihydrogenation of phenylacetylene显示文摘We report a nanocarbon material with nanodiamond(ND) core and graphene shell(ND@G) as a support for Pd nanocatalysts. The designed catalyst performed good selectivity of styrene(85.2%) at full conversion of phenylacetylene and superior stability under mild conditions. Supported Pd catalysts are characterized by means of high resolution transmission electron microscopy(HRTEM), Raman, X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS) and H2 temperature-programmed reduction(H2-TPR).The results clearly show that formation of the strong metal-support interaction(SMSI) between Pd nanoclusters and the defective graphene shell helpfully modifies the selectivity and stability of the Pd-based catalysts. | Fei Huang Zhimin Jia Jiangyong Diao Hua Yuan Dangsheng Su Hongyang Liu | 2019 | Journal of Energy Chemistry2019，28，6： | 2 |
| 5 | Non-coding RNAs in hepatitis B or C-associated hepatocellular carcinoma: Potential diagnostic and prognostic markers and therapeutic targets显示文摘 | Qi Zhang Rui Pu Yan Du Yifang Han Tong Su Hongyang Wang Guangwen Cao | 2012 | Cancer Letters2012，，1： | 1 |
| 6 | Generation of wide-swath and high-resolution SAR images from multichannel small spaceborne SAR systems显示文摘 | Zhenfang Li Hongyang Wang Tao Su | 2005 | IEEE GRS Letters2005，2，1： | 1 |
| 7 | Generation of Wide-swath and High-resolution SAR Image from Multiehannel Small Spaeeborne SAR Systems显示文摘 | Li Zhenfang Wang Hongyang Su Tao | 2005 | IEEE Geoseienee and Remote Sensing Letters2005，2，1： | 1 |
| 8 | Generation of wide-swath and high-resolution SAR images from multichannel small spaceborne SAR systems显示文摘 | Li Zhenfang Wang Hongyang Su Tao | 2005 | IEEE Geoscience and Remote Sensing Letters2005，2，1： | 1 |
| 9 | Generation of wide-swath and high-resolution SAR images from multichannel small spaceborne SAR systems显示文摘 | Li Zhenfang Wang Hongyang Su Tao and Bao Zheng | 2005 | IEEE Geoscience and Remote Sensing Letters2005，2，1： | 1 |
| 10 | Generation of wide-swath and high-resolution SAR Images From Multichannel Small Spaceborne SAR Systems显示文摘 | Zhenfang Li Hongyang Wang Tao Su Zheng Bao | 2005 | IEEE Geoscience and Remote Sensing Letters2005，2，1： | 1 |
| 11 | Gen- eration of wide-swath and high-resolution SAR ima- ges from multichannel small spaceborne SAR sys- tems显示文摘 | Li Zhenfang Wang Hongyang Su Tao | 2005 | IEEE Letters on GRS2005，2，1： | 1 |
| 12 | Phosphate modified carbon nanotubes for oxidative dehydrogenation of n-butane显示文摘Catalytic performance of phosphate-modified carbon nanotube(PoCNT) catalysts for oxidative dehydrogenation(ODH) of n-butane has been systematically investigated. The Po CNT catalysts are characterized by SEM, TEM, XPS and TG techniques. We set the products selectivity as a function of butane conversion over various phosphate loading, and it is found that the PoCNT catalyst with the 0.8% phosphate weight loading(0.8PoCNT) exhibits the best catalytic performance. When the phosphate loading is higher than 0.8 wt%, the difference of catalytic activity among the PoCNT catalysts is neglectable. Consequently, the ODH of n-butane over the 0.8PoCNT catalyst is particularly discussed via changing the reaction conditions including reaction temperatures, residence time and n-butane/O_2 ratios. The interacting mechanism of phosphate with the oxygen functional groups on the CNT surface is also proposed. | Yajie Zhang Rui Huang Zhenbao Feng Hongyang Liu Chunfeng Shi Junfeng Rong Baoning Zong Dangsheng Su | 2016 | Journal of Energy Chemistry2016，25，3： | 1 |
| 13 | Generation of Wide-swath and High-Resolutlon SAR Images From Multichannel Small Spaceborne SAR Systems显示文摘 | Li Zhengfang Wang Hongyang Su Tao | 2005 | IEEE Geoscience and Remote Sensing Letters2005，2，1： | 1 |
| 14 | The effect of bacterial contamination on the heterotrophic cultivation of Chlorella pyrenoidosa in wastewater from the production of soybean products显示文摘 | Yalei Zhang Hongyang Su Yunna Zhong Chunmin Zhang Zheng Shen Wenjing Sang Gang Yan Xuefei Zhou | 2012 | Water Research2012，，17： | 1 |
| 15 | De novo transcriptome assembly and metabolomic analysis of three tissue types in Cinnamomum cassia显示文摘Objective:The barks,leaves,and branches of Cinnamomum cassia have been historically used as a traditional Chinese medicine,spice,and food preservative,in which phenylpropanoids are responsible compounds.However phenylpropanoid biosynthesis pathways are not clear in C.cassia.We elucidated the pathways by descriptive analyses of differentially expressed genes related to phenylpropanoid biosynthesis as well as to identify various phenylpropanoid metabolites.Methods:Chemical analysis,metabolome sequencing,and transcriptome sequencing were performed to investigate the molecular mechanisms underlying the difference of active components content in the barks,branches and leaves of C.cassia.Results:Metabolomic analysis revealed that small amounts of flavonoids,coumarine,and cinnamaldehyde accumulated in both leaves and branches.Transcriptome analysis showed that genes associated with phenylpropanoid and flavonoid biosynthesis were downregulated in the leaves and branches relative to the barks.The observed differences in essential oil content among the three tissues may be attributable to the differential expression of genes involved in the phenylpropanoid and flavonoid metabolic pathways.Conclusion:This study identified the key genes in the phenylpropanoid pathway controling the flavonoid,coumarine,and cinnamaldehyde contents in the barks,branches and leaves by comparing the transcriptome and metabolome.These findings may be valuable in assessing phenylpropanoid and flavonoid metabolites and identifying specific candidate genes that are related to the synthesis of phenylpropanoids and flavonoids in C.cassia. | Hongyang Gao Huiju Zhang Yuqing Hu Danyun Xu Sikai Zheng Shuting Su Quan Yang | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
| 16 | Syntheses and catalytic applications of the high-N-content,the cup-stacking and the macroscopic nitrogen doped carbon nanotubes显示文摘The high-N-content, the cup-stacking and the macroscopic nitrogen doped carbon nanotubes(NCNT)were synthesized via an easily manufactured catalytic chemical vapor deposition(CCVD) method. Nitrogen physisorption, transmission electron microscopy(TEM), thermogravimetric analysis(TGA), X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS) were used to characterize the as-obtained NCNTs. High reaction temperatures were found to be the key point to the formation of inner-cup-stacking NCNTs. However, the synthesis of the outer-cup-stacking NCNT needs special demands not only to the reaction temperature but also to the catalyst and the carrier gas. The possibility of CO oxidation by NCNT was proved to be very small, and the outer-cup-stacking NCNT showed obvious advantage in the oxidative dehydrogenation(ODH) of butene to butadiene compared to a bamboo-like NCNT with an even higher N content. | Qi Wang Haihua Wang Yajie Zhang Guodong Wen Hongyang Liu Dangsheng Su | 2017 | Journal of Materials Science & Technology2017，33，8： | 0 |
| 17 | ZmMS39 encodes a callose synthase essential for male fertility in maize(Zea mays L.)显示文摘Callose contributes to many biological processes of higher plants including pollen development,cell plate and vascular tissue formation,as well as regulating the transport function of plasmodesmata.The functions of callose synthase genes in maize have been little studied.We describe a maize male-sterile mutant 39(ms39)characterized by reduced plant height.In this study,we confirmed using CRISPR/Cas9 technology that a mutation in Zm00001d043909(ZmCals12),encoding a callose synthase,is responsible for the male sterility of the ms39 mutant.Compared with male-fertile plants,callose deposition around the dyads and tetrads in ms39 anthers was significantly reduced.Increased cell autophagy observed in ms39 anthers may have been due to the premature programmed cell death of tapetal cells,leading to collapse of the anther wall structure.Disordered glucose metabolism in ms39 may have intensified autophagy in anthers.Evaluation of the ms39 gene on maize heterosis by paired-crossed experiment with 11 maize inbred lines indicated that ms39 can be used for maize hybrid seed production. | Qunkai Niu Ziwen Shi Peng Zhang Shuai Su Bin Jiang Xiaowei Liu Zhuofan Zhao Suzhi Zhang Qiang Huang Chuan Li Tao Yu Hongyang Yi Tingzhao Rong Moju Cao | 2023 | The Crop Journal2023，11，2： | 0 |
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