| 2 | 精索静脉曲张诱导的大鼠不育模型中E—cadherin和α—catenin在的表达显示文摘评价精索静脉曲张诱导的不育发展过程中E—cadhering和α-catenin的作用。本文分析了E—cadherin/α—catenin的表达与临床/病理参数之间的关联。取30只10周龄雄性大鼠,将左肾静脉结扎后致精索静脉曲张模型,作为实验组。取30只大鼠腹部切开处理作为对照组,取10只大鼠未做处理,作为基线组。分别记录各组大鼠4周和8周后的左睾丸的重量,血清中活性氧(ROS),睾酮,促黄体激索(LH),促卵泡激素(FSH)和生精小管的退行性改变。采用免疫组织化学法OHC)染色色Westernblot法分析E—cadherin和α—catenin的表达。与对照组和基线组相比,8周后实验组ROS增加(两组均P〈0.001)。此外,与对照组相比,478(P=0.013)和8周(P=0.032)后实验组的FSH显著增加。所有实验组中大鼠生精小管发生退行性改变的比例增加。免疫组织化学染色法的结果表明,4周和8周的实验组中E—cadherin和α-catenin的表达有所下降。Westernblot法的实验结果与免疫组化法的实验结果相近。E—eadherin和α—catenin的表达与ROS和生精小管的退行性改变是密切相关的。实验结果表明,血睾屏障(BTB)的损伤与精索静脉曲张诱导的男性不育有相关性,ROS可能会损坏血睾屏障。 | Hong Koo Ha Hyun Jun Park Nam Cheol Park | 2011 | Asian Journal of Andrology2011，13，3： | 5 |
| 3 | Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis显示文摘AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95%CI: 1.024-1.342,P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis. | Sang Jung Park Jin Dong Kim Yeon Seok Seo Beom Jin Park Min Ju Kim Soon Ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong Jung Bora Keum Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2013 | World Journal of Gastroenterology2013，19，16： | 4 |
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