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| 1 | Role of surgical resection for multiple hepatocellular carcinomas显示文摘AIM:To clarify the role of surgical resection for multiple hepatocellular carcinomas(HCCs)compared to transarterial chemoembolization(TACE)and liver transplantation(LT). METHODS:Among the HCC patients who were managed at Yonsei University Health System between January 2003 and December 2008,160 patients who met the following criteria were retrospectively enrolled:(1) two or three radiologically diagnosed HCCs;(2)no radiologic vascular invasion;(3)Child-Pugh class A;(4) main tumor smaller than 5 cm in diameter;and(5) platelet count greater than 50 000/mm3.Long-term outcomes were compared among the following three treatment modalities:surgical resection or combined radiofrequency ablation(RFA)(n=36),TACE(n=107), and LT(n=17).The survival curves were computed using the Kaplan-Meier method and compared with a log-rank test.To identify the patients who gained a survival benefit from surgical resection,we also investigated prognostic factors for survival following surgical resection.Multivariate analyses of the prognostic factors for survival were performed using the Cox proportional hazard model. RESULTS:The overall survival(OS)rate was significantly higher in the surgical resection group than in the TACE group(48.1%vs 28.9%at 5 years,P<0.005). LT had the best OS rate,which was better than that of the surgical resection group,although the difference was not statistically significant(80.2%vs 48.1%at 5 years,P=0.447).The disease-free survival rates were also significantly higher in the LT group than in the surgical resection group(88.2%vs 11.2%at 5 years, P<0.001).Liver cirrhosis was the only significant prognostic factor for poor OS after surgical resection. Clinical liver cirrhosis rates were 55.6%(20/36)in the resection group and 93.5%(100/107)in the TACE group.There were 19 major and 17 minor resections. En bloc resection was performed in 23 patients,multisite resection was performed in 5 patients,and combined resection with RFA was performed in 8 patients. In the TACE group,only 34 patients(31.8%)were recorded as having complete remission after primary TACE.Seventy-two patients(67.3%)were retreated with repeated TACE combined with other therapies. In patients who underwent surgical resection,the 16 patients who did not have cirrhosis had higher 5-year OS and disease-free survival rates than the 20 patients who had cirrhosis(80.8%vs 25.5%5-year OS rate, P=0.006;22.2%vs 0%5-year disease-free survival rate,P=0.048).Surgical resection in the 20 patients who had cirrhosis did not provide any survival benefit when compared with TACE(25.5%vs 24.7%5-year OS rate,P=0.225).Twenty-nine of the 36 patients who underwent surgical resection experienced recur-rence.Of the patients with cirrhosis,80%(16/20) were within the Milan criteria at the time of recurrence CONCLUSION:Among patients with two or three HCCs, no radiologic vascular invasion,and tumor diameters≤ 5 cm,surgical resection is recommended only in those without cirrhosis. | Sung Hoon Choi Gi Hong Choi Seung Up Kim Jun Yong Park Dong Jin Joo Man Ki Ju Myoung Soo Kim Jin Sub Choi Kwang Hyub Han Soon Il Kim | 2013 | World Journal of Gastroenterology2013，19，3： | 12 |
| 2 | Primary large cell neuroendocrine carcinoma in the common bile duct:First Asian case report显示文摘Large cell neuroendocrine carcinoma(LCNEC)in the biliary system is a poorly differentiated,high-grade neuroendocrine tumor.These tumors exhibit aggressive behavior and an increased tendency for early nodal and distant metastases.Herein,we report an unusual case of a pure primary LCNEC of the common bile duct(CBD).A 75-year-old female presented with nausea and jaundice.The patient underwent a CBD excision with lymph node dissection.Upon histological and immunohistochemical examination,the tumor exhibited pure large cell-type neuroendocrine features.Metastases were noted in two of the eight lymph nodes.The patient was administered adjuvant chemotherapy.The patient’s cancer recurred 7 mo after surgery,and the patient died from liver failure 5 mo after recurrence.The prognosis of LCNEC of CBD remains poor despitecurative resection and adjuvant chemotherapy.The role of additional therapies,such as multimodal treatment including radiation therapy,must be further studied to improve the prognoses of patients. | Sung Bae Park Suk Bae Moon Young Joon Ryu Jeana Hong Yang Hee Kim Gi Bong Chae Seong Kweon Hong | 2014 | World Journal of Gastroenterology2014，20，47： | 8 |
| 3 | Experimental investigation of friction coefficient in tube hydroforming显示文摘The friction coefficient between tube and die in guide zone of tube hydroforming was obtained. In hydroforming, the tube is expanded by an internal pressure against the tool wall. By pushing the tube through tool, a friction force at the contact surface between the tube and the tool occurs. In guiding zone, the friction coefficients between tube and die can be estimated from the measured axial feeding forces. In expansion zone, the friction coefficients between tube and die can be evaluated from the measured geometries of expanded tubes and FE analysis. | Hyae Kyung YI Hong Sup YIM Gun Yeop LEE Sung Mun LEE Gi Suk CHUNG Young-Hoon MOON | 2011 | Transactions of Nonferrous Metals Society of China2011，21，A01： | 5 |
| 4 | Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction显示文摘AIM:To investigate perfusion change in contrastenhanced ultrasonography(CEUS) to evaluate liver fibrosis based on biliary obstruction using an animal model.METHODS:New Zealand white rabbits(3-4 kg) underwent bile duct ligation to form a biliary obstruction model.We performed liver CEUS and laboratory tests on the day before the operation(day 0) and every 7 postoperative days until the rabbits were sacrificed.After CEUS,signal intensity of liver parenchyma with a time-intensity curve was analyzed.Perfusion parameters were automatically calculated from regionof-interests,including peak signal intensity,mean transit time,area under the curve and time to peak.Histological grades of liver fibrosis were assessed according to the Metavir score system immediately after sacrifice.Generalized estimating equations were used to analyze the association between liver fibrosis grades and perfusion parameters for statistical analysis.The perfusion parameters were measured on the last day and the difference between day 0 and the last day were evaluated.RESULTS:From the nine rabbits,histological grades of liver fibrosis were grade 1 in one rabbit,grade 2 and 3 in three rabbits each,and grade 4 in two rabbits.Among the four CEUS parameters,only the peak signal intensity measured on the last day demonstrated a significant association with liver fibrosis grades(OR =1.392,95%CI:1.114-1.741,P =0.004).The difference in peak signal intensity between day 0 and the last dayalso demonstrated an association with liver fibrosis(OR =1.191,95%CI:0.999-1.419,P =0.051).The other parameters tested,including mean transit time,area under the curve,and time to peak,showed no significant correlation with liver fibrosis grades.CONCLUSION:This animal study demonstrates that CEUS can be used to evaluate liver fibrosis from biliary obstruction using peak signal intensity as a parameter. | Hyun Joo Shin Eun Young Chang Hye Sun Lee Jung Hwa Hong Gyuri Park Hyun Gi Kim Myung-Joon Kim Mi-Jung Lee | 2015 | World Journal of Gastroenterology2015，21，9： | 4 |
| 5 | The Use of Adjusted Preoperative CA 19-9 to Predict the Recurrence of Resectable Pancreatic Cancer显示文摘 | Chang Moo Kang Jun Young Kim Gi Hong Choi Kyung Sik Kim Jin Sub Choi Woo Jung Lee Byong Ro Kim | 2007 | Journal of Surgical Research2007，，： | 3 |
| 6 | Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOTA显示文摘AIM: To investigate the performance of Gadofluorine P-enhanced magnetic resonance imaging(MRI) on the diagnosis of diabetes in a streptozotocin(STZ)-induced diabetic rat model.METHODS: Fischer 344 rats were treated with STZ.Rats not treated with STZ served as controls. T1-weighted MRI was performed using a 3T scanner before and after the injection of Gd-DOTA or Gadofluorine P(6 diabetic rats, 5 controls). The normalized signal intensity(SI) and the enhancement ratio(ER) of the pancreas were measured at each time point, and the values were compared between the normal and diabetic rats using the Mann-Whitney test. In addition,the values were correlated with the mean islet number.Optimal cut-off values were calculated using a positive test based on receiver operating characteristics.Intrapancreatic Gd concentration after the injection of each contrast media was measured using laser ablation-inductively coupled plasma-mass spectrometry in a separate set of rats(4 diabetic rats, 4 controls for Gadofluorine P; 2, 2 for Gd-DOTA).RESULTS: The normalized SI and ER of the pancreas using Gd-DOTA were not significantly different between diabetic rats and controls. With Gadofluorine P, the values were significantly higher in the diabetic rats than in the control rats 30 min after injection(P < 0.05). The area under the receiver operating characteristic curve that differentiated diabetic rats from the control group was greater for Gadofluorine P than for Gd-DOTA(0.967 vs 0.667, P = 0.085). An increase in normalized SI 30 min after Gadofluorine P was correlated with a decrease in the mean number of islets(r 2 = 0.510, P = 0.014). Intra-pancreatic Gd was higher in rats with Gadofluorine P injection than Gd-DOTA injection(Gadofluorine P vs Gd-DOTA, 7.37 vs 0.00, P < 0.01). A significant difference in the concentration of intrapancreatic Gd was observed between the control and diabetic animals that were sacrificed 30 min after Gadofluorine P injection(control vs diabetic, 3.25 ng/g vs 10.55 ng/g, P < 0.05)CONCLUSION: In this STZ-induced diabetes rat model,Gadofluorine P-enhanced MRI of the pancreas showed high accuracy in the diagnosis of diabetes. | Hye Rim Cho Youkyung Lee Philip Doble David Bishop Dominic Hare Young-Jae Kim Kwang Gi Kim Hye Seung Jung Kyong Soo Park Seung Hong Choi Woo Kyung Moon | 2015 | World Journal of Gastroenterology2015，21，19： | 2 |
| 7 | Outcome after curative resection for a huge (≥10 cm) hepatocellular carcinoma and prognostic significance of gross tumor classification显示文摘 | Gi Hong Choi Dai Hoon Han Dong Hyun Kim Sae Byeol Choi Chang Moo Kang Kyung Sik Kim Jin Sub Choi Young Nyun Park Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Woo Jung Lee | 2009 | The American Journal of Surgery2009，，5： | 2 |
| 8 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023，29，32： | 2 |
| 9 | Human hepatocellular carcinomas with “Stemness”‐related marker expression: keratin 19 expression and a poor prognosis显示文摘 | Haeryoung Kim Gi Hong Choi Deuk Chae Na Ei Young Ahn Gwang Il Kim Jae Eun Lee Jai Young Cho Jeong Eun Yoo Jin Sub Choi Young Nyun Park | 2011 | Hepatology2011，，5： | 2 |
| 10 | Generating artificial force for feedback control of teleoperated mobile robots 显示文摘 | Hong Sun - Gi Lee Ju - Jang Kim Seungho | 1999 | Intelligent Robots and Systems1999，3，10： | 1 |
| 11 | Heterogeneous characteristics of Korean patients with dysferlinopathy 显示文摘 | Park HJ Hong JM Suh GI | 2012 | J Korean Med Sci2012，27，4： | 1 |
| 12 | Liver Resection for Bismuth Type I and Type II Hilar Cholangiocarcinoma显示文摘 | Jin Hong Lim Gi Hong Choi Sung Hoon Choi Kyung Sik Kim Jin Sub Choi Woo Jung Lee | 2013 | World Journal of Surgery2013，，4： | 1 |
| 13 | Anti-inflammatory effects of saponins derived from the roots of Platycodongrandiflorus in lipopolysaccharide?stimulated BV2 microglial cells显示文摘 | Kyung-Jun Jang Hong Kim Min Han You Oh Hyun-Min Yoon Yoon Chung Gi Kim Hye Hwang Byung Kim Yung Choi | 2013 | International Journal of Molecular Medicine2013，，6： | 1 |
| 14 | Complication induced by decompresslve craniectomies after traumatic brain injury 显示文摘 | Yang XJ Hong GI Su SB | 2003 | Chin J Traumatol2003，6，： | 1 |
| 15 | Invasion and EMT-associated genes are up-regulated in B viral hepatocellular carcinoma with high expression of CD133-human and cell culture study显示文摘 | Deuk Chae Na Jae Eun Lee Jeong Eun Yoo Bong-Kyeong Oh Gi Hong Choi Young Nyun Park | 2010 | Experimental and Molecular Pathology2010，，1： | 1 |
| 16 | Surveillance of waste disposal activity at sea using satellite ocean color imagers: GOCI and MODIS显示文摘 | Gi Hoon Hong Dong Beom Yang Hyun-Mi Lee Sung Ryull Yang Hee Woon Chung Chang Joon Kim Young-Il Kim Chang Soo Chung Yu-Hwan Ahn Young-Je Park Jeong-Eon Moon | 2012 | Ocean Science Journal2012，，3： | 1 |
| 17 | Pure Membrane,Pseudo Membrane,and Semi Membrane Shell Theories of Hybrid Anisotropic Materials显示文摘Pure,pseudo and semi membrane theories may sound similar but totally different theories as well as its behavior.The differences are more significant when it comes to hybrid anisotropic materials,namely laminated shell wall thickness.The nomenclatures and classifications have been existed centuries for isotropic material shells since Donnell and Vlasov era.The methods of formulation of the theories are unique and never been used by others except by the authors.Governing differential equations are uniquely formulated for each theory by use of asymptotic expansion method which has never been used by others for isotropic or anisotropic materials.Longitudinal(L)and circumferential(Πor l)length scale were introduced during the course of asymptotic expansion method and the different theories among membrane theory are apparently classified.Characteristic behaviors of each theory are shown. | Chung S.W. Hong S.G. Ju Gi Su | 2018 | 材料科学与工程(中英文A版)2018，8，3： | 1 |
| 18 | Comparison of bioactive compounds, antioxidant and antiproliferative activities of Mon Thong durian during ripening显示文摘 | Ratiporn Haruenkit Sumitra Poovarodom Suchada Vearasilp Jacek Namiesnik Magda Sliwka-Kaszynska Yong-Seo Park Buk-Gu Heo Ja-Yong Cho Hong Gi Jang Shela Gorinstein | 2009 | Food Chemistry2009，，3： | 1 |
| 19 | Ten-year Comparison of All-Cause Mortality after Endovascular or Open Repair of Abdominal Aortic Aneu- rysms : A Propensity Score Analysis 显示文摘 | Hong Gi Daniel G | 2013 | World J Surg2013，37，3： | 1 |
| 20 | Long‐term outcomes and survival after laparoscopy‐assisted distal gastrectomy for gastric cancer: Three‐year survival analysis of a single‐center experience in Korea显示文摘 | Han Mo Yoo Han Hong Lee Jung Ho Shim Hae Myung Jeon Cho Hyun Park Jun Gi Kim Kyo Young Song | 2011 | J. Surg. Oncol2011，，5： | 1 |
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