|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Atheroprotective role of intedeu- kin -6 in diet - and/or pathogen - associated atherosclerosis using an ApoE heterozygote murine model显示文摘 | Madan M Bishayi B Hoge M | 2008 | Atherosclerosis2008，197，2： | 1 |
| 3 | Doxycycline affects diet - and bacteria- associated atherosclerosis in an ApoE heterozygote murine model: Cytokine profiling implications 显示文摘 | Madan M Bishayi B Hoge M | 2007 | Atherosclerosis2007，190，： | 1 |
| 4 | Satellite retrieval of the absorption coefficient of chromophoric dissolved organic matter in continental margins显示文摘 | Hoge F E Williams M E Swift R N | 1995 | Geophys Res1995，100，24： | 1 |
| 5 | Strategies for developing competency models显示文摘 | MARRELLI A F TONDORA J HOGE M A | 2005 | Administration and Policy in Mental Health2005，32，： | 1 |
| 6 | Testing the iron hypothesis in ecosystems of the equatorial Pacific Ocean 显示文摘 | Martin J H CoMe K H Johnson K S Fitzwater S E Gordon R M Tanner S J Hunter C N Elrod V A Nowicki J L Coley T L Barber R T Lindley S Watson A J Van Scoy K Law C S Liddicoat M I Ling R Stanton T Stoekel J Collins C Anderson A Bidigare R Ondrusek M Latasa M Millero F J Lee K Yao W Zhang J Z Friederich G Sakamoto C Chavez F Buck K Kolber Z Greene R Falkowski P Chisholm S W Hoge F Swift R Yangel J Turner S Nightingale P Hatton A Liss P Tindale N W | 1994 | Nature1994，371，6493： | 1 |
| 7 | Placebo-controlled trial of co-trimoxazole for Cyclospora infections among travellers and foreign residents in Nepal显示文摘 | Hoge CW Shlim DR Ghimire M | 1995 | Lancet1995，345，： | 1 |
| 8 | Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharan thusrosues 显示文摘 | Canel C Lopes-Cardoso M I Whitmer S van der Fits L van der Heijden R Hoge J H Verpoorte R | 1998 | Planta1998，205，： | 1 |
| 9 | The fundamentals of workforce competency:Implications for behavioral health显示文摘 | Hoge M A Tondora J Marrelli A F | 2005 | Admin Policy Ment Heal2005，32，5： | 1 |
| 10 | AFLP:a new technique for DNA fingerprinting显示文摘 | VOS P HOGES R BLEEKER M | 1995 | Nucleic Acids Res1995，23，21： | 1 |
| 11 | Satellite retrieval of the absorption coefficient of chromophoric dissolved organic matter in continental margins显示文摘 | HOGE F E WILLIAMS M E SWIFT R N | 1995 | Journal of Geophysical Research1995，100，24： | 1 |
| 12 | Postmortem changes in the level of brain proteins显示文摘 | Fountoulakis M Hardmeier R Hoge H | 2001 | Exp Neurol2001，167，1： | 1 |
| 13 | Doxycycline affects diet- and bacteria-associated atherosclerosis in an ApoE heterozygote murine model: cytokine profiling implications显示文摘 | Madan M Bishyi B Hoge M | 2007 | Ahteorseelor- sis2007，190，1： | 1 |
| 14 | Spacial variability of oceanic phycoerythrin spectral types derived from airborne laser-induced fluorescence emissions 显示文摘 | HOGE F E WRIGHT C W KANA T M | 1998 | Applied Optics1998，37，21： | 1 |
| 15 | Role of interleukin-1 in bacterial atherogenesis 显示文摘 | Hoge M Amar S | 2007 | Timely Top Med Cardiovasc Dis2007，11，： | 1 |
| 16 | Satellite re- trieval of the absorption coefficient of chromophoric dissolved or- ganic matter in continental margins显示文摘 | HOGE F E WILLIAMS M E SWIFT R N | 1995 | J Geophys Res1995，100，24： | 1 |
| 17 | Oxytocin levels in so- cial anxiety disorder显示文摘 | Hoge E A Pollack M H Kaufman R E | 2008 | CNS Neurosci TheL2008，14，3： | 1 |
| 18 | Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15years显示文摘 | Hoge C W Gambel J M Srijian A | 1998 | Clin Infect Dis1998，26，： | 1 |
| 19 | Doxycycline affects diet-and bacteria-associated atherosclerosis in an ApoE heterozygote murine model:cytokine profiling implications显示文摘 | Bishayi B Hoge M | 2007 | Atherosclerosis2007，190，： | 1 |
| 20 | Oxytocin levels in so- cial anxiety disorder显示文摘 | Hoge E A Pollack M H Kaufman R E | 2008 | Cns Neuroscience & Therapeutics2008，14，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员