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| 1 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 2 | Apoptosis in developing anthers and the role of ABA in this process during androgenesis in Hordeum vulgate L显示文摘 | WANG M HOEKSTRA S VAN BERGEN S LAMERS GEM OPPEDIJK B J VAN DER HEUDEN M W DE PRIESTER W SCHILPEROORT RA 1 | 1999 | Plant Mol Biol1999，39，： | 1 |
| 3 | Macruphage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences athemsclerotic lesion development in LDL receptor-deficient mice 显示文摘 | Out R Hoekstra M Hildebrand RB | 2006 | Arterioscler Thromb Vasc Biol2006，26，10： | 1 |
| 4 | The cellular responses to DNA damage显示文摘 | Carr A M Hoekstra M F | 1995 | Trends Cell Biol1995，5，： | 1 |
| 5 | Modelling of microstructured waveguides using a finite-element-based vectorial mode solver with transparent boundary conditions 显示文摘 | URANUS H P HOEKSTRA H J W M | 2004 | Opt Express2004，12，： | 1 |
| 6 | The economic impact of restricted water supply: A computable general equilibrium analysis显示文摘 | BERRITTELLA M HOEKSTRA A Y REHDANZ K | 2007 | Water Research2007，41，： | 1 |
| 7 | Comparing structural and index decomposition analysis 显示文摘 | Hoekstra R Vander Bergh J C J M | 2003 | Energy Economics2003，25，1： | 1 |
| 8 | Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias显示文摘 | Hoekstra M Mummery CL Wilde AA | | 0，，： | 1 |
| 9 | Management of giant liv- er hemangiomas: an update 显示文摘 | Hoekstra LT Bieze M Erdogan D | 2013 | Expert Rev Gastroenterol Hepa- to12013，7，3： | 1 |
| 10 | ^18FDG up-take in oesophageal adenocarcinoma: linking biology and outcome 显示文摘 | Westerterp M Sloof GW Hoekstra OS | 2008 | Cancer Res Clin Oncol2008，134，2： | 1 |
| 11 | Foodborne illness acquired in the United States-major pathogens 显示文摘 | Scallan E Hoekstra R M Angulo F J | 2011 | Emerg Infect Dis2011，17，1： | 1 |
| 12 | Prognostic value of admission glycosylated hemoglobin and glucose in nondiabetic patients with ST-segment-elevation myocardial infarction treated with percutaneous coronary intervention显示文摘 | Timmer JR Hoekstra M Nijsten MW | 2011 | Circulation2011，124，6： | 1 |
| 13 | Control of microporosity of Al2O3 pillared Clays:effect of pH,calcination temperature and Clay cation exchange capacity显示文摘 | N D Hutson M J Hoekstra R T Yang | 1999 | Microporous and Mesoporous Materials1999，28，3： | 1 |
| 14 | Is there a role for oligosaccharides in seed longevity? An assessment of intracellular glass stability显示文摘 | BUITINK J HEMMINGa M A HOEKSTRA F A | 2000 | Plant Physiol2000，122，4： | 1 |
| 15 | The peripheral blood mononuclear cell microRNA signature of coronary artery disease显示文摘 | Hoekstra M van der Lans CA Halvorsen B | 2010 | Biochem Biophys Res Commun2010，394，3： | 1 |
| 16 | The economic impact of restricted water supply: a computable general equilibrium analysis显示文摘 | BERRITTELLA M HOEKSTRA A Y REHDANZ K | 2007 | Water Research2007，41，8： | 1 |
| 17 | Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I显示文摘 | Hoekstra M Van Eck M Korporaal S J | 2012 | Curr Opin Lipidol2012，23，2： | 1 |
| 18 | Adaptive reptile color variation and the evolution of the Mcl r gene显示文摘 | ROSENBLUM E B HOEKSTRA H E NACHMAN M W | 2004 | Evolution2004，58，8： | 1 |
| 19 | Successful Treatment of Coeliac Disease by Allogeneic Haematopoietic Stem Cell Transplantation显示文摘 | J Hans Hoekstra Jacqueline J Groot-Loonen Annemieke van der Weij Peter M Hoogerbrugge Yvonne Kooy Frits Koning | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，6： | 1 |
| 20 | Estimates of Illnesses, Hospitalizations and Deaths Caused by Major Bacterial Enteric Pathogens in Young Children in the United States显示文摘 | Scallan E Mahon BE Hoekstra R M e t 01 | 2013 | The Pediatric Infectious Disease Journal2013，32，： | 1 |
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