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| 1 | Vitamin D deficiency and hepatitis viruses-associated liver diseases:a literature review显示文摘The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses(HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response(SVR) to interferon(IFN) plus ribavirin(RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBVand HCV-related chronic liver diseases. Furthermore,current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients. | Nghiem Xuan Hoan Hoang Van Tong Le Huu Song Christian G Meyer Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，4： | 9 |
| 2 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 3 | Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells显示文摘Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer cells.These nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to infrared.In this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF4:Yb^3+,Er^3+for biomedical application.After synthesis,these NaYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic acid.Folic acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via endocytosis.The sizes of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 nm.Phase structure of NaYF4:Yb^3+,Er^3+is in hexagonal crystal system.The photo luminescence(PL)spectra of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA nanophosphors were measured.These nanophosphors emit in red color with the strongest band at 650 nm under 980 nm excitation.This result can provide NaYF4:Er^3+,Yb^3+@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine. | Ha Thi Phuong Tran Thu Huong Le Thi Vinh Hoang Thi Khuyen Do Thi Thao Nguyen Thanh Huong Pham Thi Lien Le Quoc Minh | 2019 | Journal of Rare Earths2019，37，11： | 5 |
| 4 | Xanthine oxidase inhibitors from Archidendron clypearia(Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants显示文摘Objective: To screen Vietnamese medicinal plants for xanthine oxidase(XO) inhibitory activity and to isolate XO inhibitor(s) from the most active plant. Methods: The plants materials were extracted by methanol. The active plant materials were fractionated using different organic solvents, including n-hexane, ethyl acetate, and n-butanol. Bioassay-guided fractionation and column chromatography were used to isolate compounds. The compounds structures were elucidated by analysis of spectroscopic data, including IR, MS, and NMR. Results: Three hundreds and eleven methanol extracts(CME) belonging to 301 Vietnamese herbs were screened for XO inhibitory activity. Among these plants, 57 extracts displayed XO inhibitory activity at 100 μg/m L with inhibition rates of over 50%. The extracts of Archidendron clypearia, Smilax poilanei, Linociera ramiflora and Passiflora foetida exhibited the greatest potency with IC_(50) values below 30 μg/m L. Chemical study performed on the extract of Archidendron clypearia resulted in the isolation of six compounds, including 1-octacosanol, docosenoic acid, daucosterol, methyl gallate, quercitrin and(-)-7-O-galloyltricetiflavan. The compound(-)-7-O-galloyltricetiflavan showed the most potent XO inhibitory activity with an IC_(50) value of 25.5 μmol/L. Conclusions: From this investigation, four Vietnamese medicinal plants were identified to have XO inhibitory effects with IC_(50) values of the methanol extracts below 30 μg/m L. Compound(-)-7-O-galloyltricetiflavan was identified as an XO inhibitor from Archidendron clypearia with IC_(50) value of 25.5 μmol/L. | Nguyen Thuy Duong Pham Duc Vinh Phuong Thien Thuong Nguyen Thi Hoai Le Nguyen Thanh Tran The Bach Nguyen Hai Nam Nguyen Hoang Anh | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，6： | 5 |
| 5 | Intraocular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C显示文摘We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha (IFN-α) treatment in eight hepatitis C virus (HCV)-infected patients. These events include three cases of Vogt-Koyanagi-Harada like (VKH) disease (an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes), two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α treatment with ophthalmological monitoring if any ocular manifestation occurs. | Damien Sène Valérie Touitou Bahram Bodaghi David Saadoun Gabriel Perlemuter Nathalie Cassoux Jean-Charles Piette Phuc Le Hoang Patrice Cacoub | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 6 | Univector field method-based multi-agent navigation for pursuit problem in obstacle environments显示文摘The pursuit problem is a well-known problem in computer science. In this problem, a group of predator agents attempt to capture a prey agent in an environment with various obstacle types, partial observation, and an infinite grid-world. Predator agents are applied algorithms that use the univector field method to reach the prey agent, strategies for avoiding obstacles and strategies for cooperation between predator agents. Obstacle avoidance strategies are generalized and presented through strategies called hitting and following boundary(HFB); trapped and following shortest path(TFSP); and predicted and following shortest path(PFSP). In terms of cooperation, cooperation strategies are employed to more quickly reach and capture the prey agent. Experimental results are shown to illustrate the efficiency of the method in the pursuit problem. | Le Pham Tuyen Hoang Huu Viet Sang Hyeok An Seung Gwan Lee Dong-Han Kim Tae Choong Chung | 2017 | Journal of Central South University2017，24，4： | 3 |
| 7 | It Takes Two to Tango: Entrepreneurship and Creativity in Troubled Times--Vietnam 2012显示文摘 | Nancy K. Napier Dang Le Nguyen Vu Quan Hoang Vuong | 2012 | Journal of Sociology Study2012，2，9： | 2 |
| 8 | Fabrication and properties of high efficiency luminescent nanorods EuPO_4·H_2O by soft template method显示文摘Europium orthophosphate monohydrate(EuPO4·H2O) nanorods with typical dimensions of about 10-30 nm in diameter and 300-500 nm in length were prepared by using the soft template method.The effects of using diethylene glycol(DEG) and polyethylene gly-col(PEG) polymers as well as the pH values on the size,crystalline structure and morphology of EuPO4·H2O nanorods were investigated.Field emission scanning electron microscopy(FESEM) and X-ray diffraction(XRD) data of the prepared samples were elucidated.The nano-rods were highly uniform and their mean length was reduced by using DEG and PEG as soft template agents.For all prepared samples,the rhabdophane-type hexagonal EuPO4·H2O was the dominated phase.The photoluminescence(PL) spectroscopy measurements of EuPO4·H2O nanorods revealed that,under UV excitation,EuPO4·H2O nanorods exhibited strong luminescence with narrow bands corresponding to the in-tra-4f transitions of 5D0→7Fj(j=1,2,3,4) of Eu3+ ions.The peaks were found at 594 nm(5D0→7F1) ,619 nm(5D0→7F2) ,652 nm(5D0→7F3) ,and 697 nm(5D0→7F4) ,with the strongest emission at 594 nm. | Tran Thu Huong Tran Kim Anh Le Thi Vinh W.Strek Hoang Thi Khuyen Le Quoc Minh | 2011 | Journal of Rare Earths2011，29，12： | 2 |
| 9 | The influence of tantalum content in relation to substrate temperature on magnetic and structural properties of Co-Cr-Ta thin films显示文摘 | PHAN LE KIM COCK LODDER NGUYEN HOANG LUONG | 1999 | Journal of Magnetism and Magnetic Materials1999，193，： | 1 |
| 10 | Locally weighted learning based hybrid intelligence models for groundwater potential mapping and modeling: A case study at Gia Lai province, Vietnam显示文摘The groundwater potential map is an important tool for a sustainable water management and land use planning,particularly for agricultural countries like Vietnam.In this article,we proposed new machine learning ensemble techniques namely AdaBoost ensemble(ABLWL),Bagging ensemble(BLWL),Multi Boost ensemble(MBLWL),Rotation Forest ensemble(RFLWL)with Locally Weighted Learning(LWL)algorithm as a base classifier to build the groundwater potential map of Gia Lai province in Vietnam.For this study,eleven conditioning factors(aspect,altitude,curvature,slope,Stream Transport Index(STI),Topographic Wetness Index(TWI),soil,geology,river density,rainfall,land-use)and 134 wells yield data was used to create training(70%)and testing(30%)datasets for the development and validation of the models.Several statistical indices were used namely Positive Predictive Value(PPV),Negative Predictive Value(NPV),Sensitivity(SST),Specificity(SPF),Accuracy(ACC),Kappa,and Receiver Operating Characteristics(ROC)curve to validate and compare performance of models.Results show that performance of all the models is good to very good(AUC:0.75 to 0.829)but the ABLWL model with AUC=0.89 is the best.All the models applied in this study can support decision-makers to streamline the management of the groundwater and to develop economy not only of specific territories but also in other regions across the world with minor changes of the input parameters. | Hoang Phan Hai Yen Binh Thai Pham Tran Van Phong Duong Hai Ha Romulus Costache Hiep Van Le Huu Duy Nguyen Mahdis Amiri Nguyen Van Tao Indra Prakash | 2021 | Geoscience Frontiers2021，12，5： | 1 |
| 11 | Ecoregional variations of aboveground biomass and stand structure in evergreen broadleaved forests显示文摘Biotic and abiotic factors control aboveground biomass(AGB)and the structure of forest ecosystems.This study analyses the variation of AGB and stand structure of evergreen broadleaved forests among six ecoregions of Vietnam.A data set of 1731-ha plots from 52 locations in undisturbed old-growth forests was developed.The results indicate that basal area and AGB are closely correlated with annual precipitation,but not with annual temperature,evaporation or hours of sunshine.Basal area and AGB are positively correlated with trees>30 cm DBH.Most areas surveyed(52.6%)in these old-growth forests had AGB of 100–200 Mg ha^-1;5.2%had AGB of 400–500 Mg ha^-1,and 0.6%had AGB of>800 Mg ha^-1.Seventy percent of the areas surveyed had stand densities of 300–600 ind.ha^-1,and 64%had basal areas of 20–40 m^2 ha^-1.Precipitation is an important factor influencing the AGB of old-growth,evergreen broadleaved forests in Vietnam.Disturbances causing the loss of large-diameter trees(e.g.,>100 cm DBH)affects AGB but may not seriously affect stand density. | Tran Van Do Mamoru Yamamoto Osamu Kozan Vo Dai Hai Phung Dinh Trung Nguyen Toan Thang Lai Thanh Hai Vu Thanh Nam Trieu Thai Hung Hoang Van Thang Tran Duc Manh Cao Chi Khiem Vu Tien Lam Nguyen Quang Hung Tran Hoang Quy Pham Quang Tuyen Trinh Ngoc Bon Nguyen Thi Thu Phuong Ninh Viet Khuong Nguyen Van Tuan Dang Thi Hai Ha Tran Hai Long Dang Van Thuyet Dang Thinh Trieu Nguyen Van Thinh Tran Anh Hai Duong Quang Trung Nguyen Van Bich Dinh Hai Dang Pham Tien Dung Nguyen Huy Hoang Le Thi Hanh Phan Minh Quang Nguyen Thi Thuy Huong Hoang Thanh Son Nguyen Thanh Son Nguyen Thi Van Anh Nguyen Thi Hoai Anh Pham Dinh Sam Hoang Thi Nhung Hoang Van Thanh Nguyen Huu Thinh Tran Hong Van Ho Trung Luong Bui Kieu Hung | 2020 | Journal of Forestry Research2020，31，5： | 1 |
| 12 | Design and optimization of a torque controller for a switched reluctance motor drive for electric vehicles by simulation 显示文摘 | David Cajander Hoang Le Huy | 2006 | Mathematics and Computers in Simulation2006，71，4： | 1 |
| 13 | Abnormalities of the ocular surface in patients with AIDS显示文摘 | Burtin T Guepratte N Bourges JL Garcher C Le Hoang P Bau- douln C | 1998 | J Fr Ophtalmol1998，21，9： | 1 |
| 14 | Characterization and activity of Fe-ZSM-5 catalysts for the total oxidation of phenol in aqueous solutions显示文摘 | Nguyen Huu Phu Tran Thi Kim Hoa Nguyen Van Tan Hoang Vinh Thang Pham Le Ha | 2001 | Applied Catalysis B Environmental2001，，4： | 1 |
| 15 | Alagille syndrome in a Vietnamese cohort: mutation analysis and assessment of facial features显示文摘 | Lin HC Le Hoang P Hutchinson A | 2012 | Am J Med Genet A2012，158，5： | 1 |
| 16 | Face recognition based on SVM and 2DPCA 显示文摘 | Thai Hoang Le Len Bui | 2011 | International Journal of Signal Processing Image Processing and Pattern Recognition2011，4，3： | 1 |
| 17 | Primary Intraocular Lymphoma: Diagnosis and Differential Diagnosis显示文摘 | H. Nida Sen Bahram Bodaghi Phuc Le Hoang Robert Nussenblatt | 2009 | Ocular Immunology and Inflammation2009，，3： | 1 |
| 18 | Mean-field description of heavy-ion scattering at low energies and fusion显示文摘The nuclear mean-field potential built up during the ^(12)C+^(12)C and ^(16)O+^(16)O collisions at low energies relevant for the carbon-and oxygen-burning processes is constructed within the double-folding model(DFM) using the realistic ground-state densities of^(12)C and^(16)O, and CDM3Yn density-dependent nucleon–nucleon(NN) interaction. The rearrangement term, indicated by the Hugenholtz–van Hove theorem for the single-particle energy in nuclear matter, is properly considered in the DFM calculation. To validate the use of the density-dependent NN interaction at low energies, an adiabatic approximation was suggested for the dinuclear overlap density. The reliability of the nucleus–nucleus potential predicted through this low-energy version of the DFM was tested in the optical model(OM) analysis of the elastic^(12)C+^(12)C and ^(16)O+^(16)O scattering data at energies below 10 MeV/nucleon.These OM results provide a consistently good description of the elastic angular distributions and 90 excitation function. The dinuclear mean-field potential predicted by the DFM is further used to determine the astrophysical S factor of the ^(12)C+^(12)C and ^(16)O+^(16)O fusions in the barrier penetration model. Without any adjustment of the potential strength, our results reproduce the non-resonant behavior of the S factor of the ^(12)C+^(12)C and ^(16)O+^(16)O fusions very well over a wide range of energies. | Dao T.Khoa Le Hoang Chien Do Cong Cuong Nguyen Hoang Phuc | 2018 | Nuclear Science and Techniques2018，29，12： | 1 |
| 19 | Aedesaegypti in south Vietnam: ecology, genetic structure, vectorial competence and re- sistance to insecticides显示文摘 | Huber K Le Loan L Hoang TH | 2003 | Southeast Asian J Trop Med Public Health2003，34，1： | 1 |
| 20 | Moderate GSK-3β inhibition improves neovascular architecture,reduces vascular leakage,and reduces retinal hypoxia in a model of ischemic retinopathy显示文摘 | Hoang MV Smith LE Senger DR | 2010 | Angiogenesis2010，13，3： | 1 |
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