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| 1 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 2 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 3 | Endoscopic Pancreatic Duct Stents Reduce the Incidence of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis in High-Risk Patients显示文摘 | Atsushi Sofuni Hiroyuki Maguchi Tsuyoshi Mukai Hiroshi Kawakami Atsushi Irisawa Kensuke Kubota Shinji Okaniwa Masataka Kikuyama Hiromu Kutsumi Keiji Hanada Toshiharu Ueki Takao Itoi | 2011 | Clinical Gastroenterology and Hepatology2011，，10： | 1 |
| 4 | Controllable alignment of elongated microorganisms in 3D microspace using electrofluidic devices manufactured by hybrid femtosecond laser microfabrication显示文摘This paper presents a simple technique to fabricate new electrofluidic devices for the three-dimensional(3D)manipulation of microorganisms by hybrid subtractive and additive femtosecond(fs)laser microfabrication(fs laser-assisted wet etching of glass followed by water-assisted fs laser modification combined with electroless metal plating).The technique enables the formation of patterned metal electrodes in arbitrary regions in closed glass microfluidic channels,which can spatially and temporally control the direction of electric fields in 3D microfluidic environments.The fabricated electrofluidic devices were applied to nanoaquariums to demonstrate the 3D electro-orientation of Euglena gracilis(an elongated unicellular microorganism)in microfluidics with high controllability and reliability.In particular,swimming Euglena cells can be oriented along the z-direction(perpendicular to the device surface)using electrodes with square outlines formed at the top and bottom of the channel,which is quite useful for observing the motions of cells parallel to their swimming directions.Specifically,z-directional electric field control ensured efficient observation of manipulated cells on the front side(45 cells were captured in a minute in an imaging area of~160×120μm),resulting in a reduction of the average time required to capture the images of five Euglena cells swimming continuously along the z-direction by a factor of~43 compared with the case of no electric field.In addition,the combination of the electrofluidic devices and dynamic imaging enabled observation of the flagella of Euglena cells,revealing that the swimming direction of each Euglena cell under the electric field application was determined by the initial body angle. | Jian Xu Hiroyuki Kawano Weiwei Liu Yasutaka Hanada Peixiang Lu Atsushi Miyawaki Katsumi Midorikawa Koji Sugioka | 2017 | Microsystems & Nanoengineering2017，3，1： | 1 |
| 5 | Operating Conditions and Microcapsules Generated by in Situ Polymerization 显示文摘 | HIROYUKI KAGE HIDEAKI KAWAHARA NAOMICHI HANADA | 2002 | Advanced Power Technol2002，13，3： | 1 |
| 6 | Multicenter retrospective study of endoscopic ultrasound‐guided biliary drainage for malignant biliary obstruction in J apan显示文摘 | Kazumichi Kawakubo Hiroyuki Isayama Hironari Kato Takao Itoi Hiroshi Kawakami Keiji Hanada Hirotoshi Ishiwatari Ichiro Yasuda Hirofumi Kawamoto Fumihide Itokawa Masaki Kuwatani Tomohiro Iiboshi Tsuyoshi Hayashi Shinpei Doi Yousuke Nakai | 2014 | J Hepatobiliary Pancreat Sci2014，，5： | 1 |
| 7 | Endoscopic Pancreatic Duct Stents Reduce the Incidence of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis in High-Risk Patients显示文摘 | Atsushi Sofuni Hiroyuki Maguchi Tsuyoshi Mukai Hiroshi Kawakami Atsushi Irisawa Kensuke Kubota Shinji Okaniwa Masataka Kikuyama Hiromu Kutsumi Keiji Hanada Toshiharu Ueki Takao Itoi | 2011 | Clinical Gastroenterology and Hepatology2011，，10： | 1 |
| 8 | Low oxygen tension during in vitro maturation of porcine follicular oocytes improves parthenogenetic activation and subsequent development to the blastocyst stage显示文摘 | Masaki Iwamoto Akira Onishi Dai-ichiro Fuchimoto Tamas Somfai Kumiko Takeda Takahiro Tagami Hirofumi Hanada Junko Noguchi Hiroyuki Kaneko Takashi Nagai Kazuhiro Kikuchi | 2004 | Theriogenology2004，，5： | 1 |
| 9 | A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer显示文摘 | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Yukiko Ito Ichiro Yasuda Nobuo Toda Hirofumi Kogure Keiji Hanada Hiroyuki Maguchi Naoki Sasahira Hideki Kamada Tsuyoshi Mukai Yoshihiro Okabe Osamu Hasebe Iruru Maetani Kazuhiko Koike | 2013 | Cancer Chemotherapy and Pharmacology2013，，4： | 1 |
| 10 | 尼可地尔改善首选经皮冠状动脉介入治疗的急性心肌梗死患者的心脏功能和临床预后——抑制活性氧生成的作用显示文摘(接5月下)3.1尼可地尔对活性氧的形成作用除了其对冠状动脉扩张和心脏保护的效果,尼可地尔已经显示出具有抗自由基的作用。据Pieper and Gross报告,尼可地尔抑制铁催化的羟基自由基介导的脱氧核糖的降解。 | Hirotsugu Ono Tomohiro Osanai Hiroshi Ishizaka Hiroyuki Hanada 高万峰 | 2017 | 首都食品与医药2017，24，12： | 1 |
| 11 | Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in patients with acute coronary syndrome 显示文摘 | Yoichi Inokubo Hiroyuki Hanada Hiroshi Ishizaka | 2001 | Am Heart J2001，141，2： | 1 |
| 12 | Treatment outcomes of chemotherapy between unresectable and recurrent biliary tract cancer显示文摘AIM:To evaluate the differences in the treatment outcomes between the unresectable and recurrent biliary tract cancer patients who received chemotherapy.METHODS:Patients who were treated with gemcitabine and S-1 combination therapy in the previous prospective studies were divided into groups of unresectable and recurrent cases.The tumor response,time-toprogression,overall survival,toxicity,and dose intensity were compared between these two groups.RESULTS:Response rate of the recurrent group was higher than that of the unresectable group(40.0%vs25.5%;P=0.34).Median time-to-progression of the recurrent and unresectable groups were 8.7 mo(95%CI),1.2 mo,not reached)and 5.7 mo(95%CI:4.0-7.0 mo),respectively(P=0.14).Median overall survival of the recurrent and the unresectable groups were 16.1 mo(95%CI:2.0 mo-not reached)and 9.6 mo(95%CI:7.1-11.7 mo),respectively(P=0.10).Dose intensities were significantly lower in the recurrent groups(gemcitabine:recurrent group 83.5%vs unresectable group 96.8%;P<0.01,S-1:Recurrent group 75.9%vs unresectable group 91.8%;P<0.01).Neutropenia occurred more frequently in recurrent group(recurrent group 90%vs unresectable group 55%;P=0.04).CONCLUSION:Not only the efficacy but also the toxicity and dose intensity were significantly different between unresectable and recurrent biliary tract cancer. | Takashi Sasaki Hiroyuki Isayama Yousuke Nakai Yukiko Ito Ichiro Yasuda Nobuo Toda Hiroshi Yagioka Saburo Matsubara Keiji Hanada Hiroyuki Maguchi Hideki Kamada Osamu Hasebe Tsuyoshi Mukai Yoshihiro Okabe Iruru Maetani Kazuhiko Koike | 2014 | World Journal of Gastroenterology2014，20，48： | 0 |
| 13 | 尼可地尔改善首选经皮冠状动脉介入治疗的急性心肌梗死患者的心脏功能和临床预后——抑制活性氧生成的作用显示文摘(接6月下)Ito等人报道,对于急性心肌梗死患者,再灌注治疗之前静脉注射尼可地尔可以保持微血管的完整性,降低无溢流现象的发生率,改善心肌存活及功能,提高临床疗效。此外,Sugimoto等人发现,在尼可地尔结合与再灌注治疗能够改善急性心肌梗死患者,尤其是前壁心肌梗塞患者的左心室功能,提高长期预后。 | Hirotsugu Ono Tomohiro Osanai Hiroshi Ishizaka Hiroyuki Hanada 高万峰 | 2017 | 首都食品与医药2017，24，14： | 0 |
| 14 | 尼可地尔改善首选经皮冠状动脉介入治疗的急性心肌梗死患者的心脏功能和临床预后——抑制活性氧生成的作用显示文摘侧支血管通过Rentrop定义成灌注等级2级或3级,梗死相关动脉镜内观察6组1例和8组有2例(PNS)。基利普和Forrester分类的程度在入院两组之间是相似的。 | Hirotsugu Ono Tomohiro Osanai Hiroshi Ishizaka Hiroyuki Hanada 高万峰 | 2017 | 首都食品与医药2017，24，10： | 0 |
| 15 | 尼可地尔改善首选经皮冠状动脉介入治疗的急性心肌梗死患者的心脏功能和临床预后——抑制活性氧生成的作用显示文摘(接3月下)在PCI手术后持续进行48小时静脉注射肝素以维持活化凝血时间超过180秒。对于所有患者,该程序是在获准入院后60分钟内,最终的冠状动脉造影显示残余狭窄小于管腔直径的25%。对于串行尿液取样,在所有患者的膀胱插入球囊导管完成。尿液样本为PCI手术之前,直到初始PCI手术后150分钟后,每30分钟连续获得(基线),并收集到含抗氧化剂丁基羟基茴香醚(0.1%)的聚乙烯管中。样品在收集期间保持冷藏,并储存在零下80℃直至测定分析。 | Hirotsugu Ono Tomohiro Osanai Hiroshi Ishizaka Hiroyuki Hanada 高万峰 | 2017 | 首都食品与医药2017，24，8： | 0 |
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