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| 1 | CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath显示文摘钙绑定酷氨酸调整 phosphorylation 的蛋白质(CABYR ) 是高度多态的钙绑定 tyrosine-/threonine-phosphorylated 和 serine-/threonine-phosphorylated 涉及 capacitation 的含纤维的鞘(FS ) 蛋白质。一个通常认为的领域(氨基酸 12 鈥 ? 8 ) 对类型 II 营地依赖者蛋白质 kinase A (RII ) dimerisation 和抛锚 kinase 蛋白质(AKAP ) 的规章的子单元相应在 N 终点的蛋白质 kinase A 的有约束力的领域建议那 CABYR 可以自我装配并且绑在 AKAP。而且,有证据, CABYR 与 AKAP 限制了相互作用。然而,推进在 CABYR 之间的证据和新关系,包括 AKAP,另外的 FS 蛋白质将在理解 FS 的基本生理学是有用的。在这研究,为不可溶解的蛋白质的 co-immunoprecipitation 的新策略,以及在有集体 spectrometry 和西方的污点的联合的标准 co-immunoprecipitation 方法,被采用探索在 CABYR, AKAP3 和 Ropporin 之间的关系。结果证明 AKAP3 是有由 anti-CABYR-A polyclonal 抗体的 CABYR 的 co-immunoprecipitated,并且,相反地, CABYR 也是有由 anti-AKAP3 polyclonal 抗体的 AKAP3 的 co-immunoprecipitated。包含蛋白质的另一象 RII 一样域, Ropporin,也是有 CABYR 的 co-immunoprecipitated,显示 Ropporin 是 CABYR 的绑定之一合伙。在 CABYR, AKAP3 和 Ropporin 之间的相互作用被酵母证实二混血儿的试金。进一步的分析显示出那 CABYR 不仅由它的 RII 领域绑在 AKAP3 而且除象 RII 一样领域以外通过另外的区域绑在 Ropporin。这是 CABYR 变体形成的第一示范不仅有 scaffolding 蛋白质 AKAP3 而且与在人的精子 FS 的另一象 RII 一样包含域的蛋白质的建筑群。 | Yan-Feng Li Wei He Arabinda Mandal Young-Hwan Kim Laura Digilio Ken Klotz Charles J Flickinger John C Herr | 2011 | Asian Journal of Andrology2011，13，2： | 5 |
| 2 | Long-term follow-up study of gastroduodenal lesions after radioembolization of hepatic tumors显示文摘AIM:To evaluate the long-term natural history of the gastroduodenal lesions secondary to extrahepatic embolization with Ytrium 90(90 Y) spheres.METHODS:From September 2003 to January 2012,379 procedures of liver radioembolization(RE) using resin microspheres loaded with 90 Y were performed in our center.We have retrospectively compiled the data from 379 RE procedures performed in our center.We report a comprehensive clinical,analytical,endoscopic and histologic long-term follow-up of a series of patients who developed gastroduodenal lesions after the treatment.RESULTS:Six patients(1.5%) developed gastrointestinal symptoms and had gastrointestinal lesions as shown by upper endoscopy in the next 12 wk after RE.The mean time between RE and the appearance of symptoms was 5 wk.Only one patient required endoscopic and surgical treatment.The incidence of gastrointestinal ulcerations was 3.75%(3/80) when only planar images were used for the pre-treatment evaluation.It was reduced to 1%(3/299) when singlephoton emission computed tomography(SPECT) images were also performed.The symptoms that lasted for a longer time were nausea and vomiting,until 25 mo after the treatment.CONCLUSION:All patients were free from severe symptoms at the end of follow-up.The routine use of SPECT has decreased the incidence of gastrointestinal lesions due to unintended deployment of 90 Y particles. | Iago Rodríguez-Lago Cristina Carretero Maite Herráiz José C Subtil Maite Betés Macarena Rodríguez-Fraile Jesús J Sola José I Bilbao Miguel Muoz-Navas Bruno Sangro | 2013 | World Journal of Gastroenterology2013，19，19： | 2 |
| 3 | Two-dimensionalgel electrophoretie analysis of vectorially labeled surface proteins of human spermatozoa 显示文摘 | Naaby Hansen S Flickinger C J Herr J C | 1997 | Biol Reprod1997，56，3： | 1 |
| 4 | Ion-gated electron transfer in self-assembled monolayer films 显示文摘 | Campbell D J Herr B R Hulteen J C | 1996 | J Am Chem Soc1996，118，10： | 1 |
| 5 | Field trial to evaluate immunogenicity of a glycoprotein I (gE) - deleted pseudorabies virus vaccine after its administration in the presence ofmaternal antibodies显示文摘 | Weigel R M Lehman J R Herr L Hahn E C | 1995 | Am J Vet Res1995，56，9： | 1 |
| 6 | Evaluation of the revised faces pain scale, verbal descriptor sclae, numeric rating scale, and iowa pain thermometer in older minority adults显示文摘 | WARE L J EPPS C D HERR K | 2006 | Pain Manag Nurs2006，7，： | 1 |
| 7 | Physicians Appeals on the Dangers of Mobile Communication-what is the Evidence? Assessment of Public Health Data显示文摘 | Nieden A Z Dietz C Eikmann T Kiefer J Herr C E W | 2009 | International Journal of Hygiene and Environmental Health2009，，212： | 1 |
| 8 | Model calcula- tions of total maximum daily loads of mercury for drainage lakes显示文摘 | CHEN C W HERR J W GOLDSTEIN R A | 2008 | Journal of the American Water Resources Associa- tion2008，44，5： | 1 |
| 9 | A quasi-passive leg exoskeleton for load-carrying augmentation显示文摘 | WALSH C J ENDO K HERR H | | 0，，05： | 1 |
| 10 | Aptamer-conjugated nanoparticles for selective collection and detection of cancer cells 显示文摘 | Herr J K Smith J E Medley C D | 2006 | Anal Chem2006，78，： | 1 |
| 11 | Ser18 and 23 phosphoryl- ation is required for p53 -dependent apoptosis and tumor suppression 显示文摘 | Chao C Herr D Chun J | 2006 | The EMBO Journal2006，25，： | 1 |
| 12 | Retrospective comparison of watershed analysis risk management framework and hydrologic simulation program Fortran applications to Mica Creek watershed显示文摘 | Carl C W Herr J W Goldstein R A | 2005 | J Envir Eng2005，131，9： | 1 |
| 13 | The effect of soidium chloride on gerimination and the potassium and calcium contentsof Acacia seeds显示文摘 | Ehman S R Herres P J C Bourne W F | 1996 | Seed Techn ol1996，，25： | 1 |
| 14 | Aptamer - conjugated nanoparticles for selective collection and detection of cancer cells 显示文摘 | Herr J K Smith J E Medley C D | 2006 | Analytical Chemistry2006，78，9： | 1 |
| 15 | Immunolocalization of extracellular matrix proteins and collagen synthesis in first-trimester human decidua显示文摘 | Kisalus L L Herr J C Little C D | | 0，，4： | 1 |
| 16 | A novel asparaginase- like protein is a sperm autoantigen in rats显示文摘 | BUSH L A HERR J C WOLKOWICZ M | 2002 | Mol Reprod Dev2002，62，2： | 1 |
| 17 | The effect of soidium chloride on germination and the potassium and calcium contents of Acacia seeds显示文摘 | EHMAN S R HERRES P J C BOURNE W F | 1996 | Seed Technol1996，25，： | 1 |
| 18 | Pseudomonas aeruginosa hypoxic or anaerobic bio-film infections within cystic fibrosis airways显示文摘 | Hassett D J Sutton M D Schurr M J Herr A B Caldwell C C Matu J 0 | 2009 | Trends Micro-biol2009，17，： | 1 |
| 19 | Sperm antigens and their use in the development of an immunocontraceptive 显示文摘 | DIEKMAN A B HERR J C | 1997 | Am J Reprod Immunol1997，37，： | 1 |
| 20 | Aptamer-conjugated nanop-articles for selective collection and detection of cancer cells显示文摘 | HERR J K SMITH J E MEDLEY C D | 2006 | Analytical Chemistry2006，78，9： | 1 |
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