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| 1 | Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document显示文摘 | Giuseppe Mancia Stéphane Laurent Enrico Agabiti-Rosei Ettore Ambrosioni Michel Burnier Mark J Caulfield Renata Cifkova Denis Clément Antonio Coca Anna Dominiczak Serap Erdine Robert Fagard Csaba Farsang Guido Grassi Hermann Haller Anthony Heagerty Sverre | 2009 | Journal of Hypertension2009，，： | 2 |
| 2 | Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document显示文摘 | Giuseppe Mancia Stéphane Laurent Enrico Agabiti-Rosei Ettore Ambrosioni Michel Burnier Mark J. Caulfield Renata Cifkova Denis Clément Antonio Coca Anna Dominiczak Serap Erdine Robert Fagard Csaba Farsang Guido Grassi Hermann Haller Antony Heagerty Sverre | 2009 | Blood Pressure2009，，6： | 1 |
| 3 | “Zebrafishing” for Novel Genes Relevant to the Glomerular Filtration Barrier显示文摘 | Nils Hanke Lynne Staggs Patricia Schroder Jennifer Litteral Susanne Fleig Jessica Kaufeld Cornelius Pauli Hermann Haller Mario Schiffer Richard Tucker | 2013 | BioMed Research International2013，，： | 1 |
| 4 | C-X3-C motif chemokine ligand 1/receptor 1 regulates the M1 polarization and chemotaxis of macrophages after hypoxia/reoxygenation injury显示文摘Background:Macrophages play an important role in renal ischemia reperfusion injury,but the functional changes of macrophages under hypoxia/reoxygenation and the related mechanism are unclear and need to be further clarified.Methods:The effects of hypoxia/reoxygenation on functional characteristics of RAW264.7 macrophages were analyzed through the protein expression detection of pro-inflammatory factors TNF-αand CD80,anti-inflammatory factors ARG-1 and CD206.The functional implications of C-X3-C motif chemokine receptor 1(CX3CR1)down-regulation in hypoxic macrophages were explored using small interfering RNA technology.Significance was assessed by the parametrict-test or nonparametric Mann-Whitney test for two group comparisons,and a one-way ANOVA or the Kruskal-Wallis test for multiple group comparisons.Results:Hypoxia/reoxygenation significantly increased the protein expression of M1-related pro-inflammatory factors TNF-α,CD80 and chemokine C-X3-C motif chemokine ligand 1(CX3CL1)/CX3CR1 and inhibited the protein expression of M2-related anti-inflammatory factors ARG-1 and CD206 in a time-dependent manner in RAW264.7 cells.However,the silencing of CX3CR1 in RAW264.7 cells using specific CX3CR1-siRNA,significantly attenuated the increase in protein expression of TNF-α(P<0.05)and CD80(P<0.01)and the inhibition of ARG-1(P<0.01)and CD206(P<0.01)induced by hypoxia/reoxygenation.In addition,we also found that hypoxia/reoxygenation could significantly enhance the migration(2.2-fold,P<0.01)and adhesion capacity(1.5-fold,P<0.01)of RAW264.7 macrophages compared with the control group,and CX3CR1-siRNA had an inhibitory role(40%and 20%reduction,respectively).For elucidating the mechanism,we showed that the phosphorylation levels of ERK(P<0.01)and the p65 subunit of NF-κB(P<0.01)of the RAW264.7 cells in the hypoxic/reoxygenation group were significantly increased,which could be attenuated by down-regulation of CX3CR1 expression(P<0.01,both).ERK inhibitors also significantly blocked the effects of hypoxic/reoxygenation on the protein expression of M1-related pro-inflammatory factors TNF-α,CD80 and M2-related anti-inflammatory factors ARG-1 and CD206.Moreover,we found that conditioned medium from polarized M1 macrophages induced by hypoxia/reoxygenation,notably increased the degree of apoptosis of hypoxia/reoxygenation-induced TCMK-1 cells,and promoted the protein expression of pro-apoptotic proteins bax(P<0.01)and cleaved-caspase 3(P<0.01)and inhibited the expression of anti-apoptotic protein bcl-2(P<0.01),but silencing CX3CR1 in macrophages had a protective role.Finally,we also found that the secretion of soluble CX3CL1 in RAW264.7 macrophages under hypoxia/reoxygenation was significantly increased.Conclusions:The findings suggest that hypoxia/reoxygenation could promote M1 polarization,cell migration,and adhesion of macrophages,and that polarized macrophages induce further apoptosis of hypoxic renal tubular epithelial cells by regulating of CX3CL1/CX3CR1 signaling pathway. | Shuiming Guo Lei Dong Junhua Li Yuetao Chen Ying Yao Rui Zeng Nelli Shushakova Hermann Haller Gang Xu Song Rong | 2021 | Chronic Diseases and Translational Medicine2021，7，4： | 1 |
| 5 | High impact of rejection therapy on the incidence of post‐transplant diabetes mellitus after kidney transplantation显示文摘 | Torben Schweer Wilfried Gwinner Irina Scheffner Anke Schwarz Hermann Haller Cornelia Blume | 2014 | Clin Transplant2014，，4： | 1 |
| 6 | Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy显示文摘 | Sajoscha A. Sorrentino Christian Besler Lucia Rohrer Martin Meyer Kathrin Heinrich Ferdinand H. Bahlmann Maja Mueller Tibor Horváth Carola Doerries Mariko Heinemann Stella Flemmer Andrea Markowski Costantina Manes Matthias J. Bahr Hermann Haller Arnold vo | 2010 | Circulation2010，，1： | 1 |
| 7 | Requirement for Protein Kinase C in Reactive Oxygen Species- Induced Apoptosis of Vascular Smooth Muscle Cells显示文摘 | Pei - Feng Li Christian Maasch Hermann Haller | 1999 | Circulation1999，100，： | 1 |
| 8 | Amelioration of Angiotensin II–Induced Cardiac Injury by a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor显示文摘 | Ralf Dechend Anette Fiebeler Joon-Keun Park Dominik N. Muller Juergen Theuer Eero Mervaala Markus Bieringer Dietrich Gulba Rainer Dietz Friedrich C. Luft Hermann Haller | 2001 | Circulation: Journal of the American Heart Association2001，，5： | 1 |
| 9 | Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy显示文摘 | Sajoscha A. Sorrentino Christian Besler Lucia Rohrer Martin Meyer Kathrin Heinrich Ferdinand H. Bahlmann Maja Mueller Tibor Horváth Carola Doerries Mariko Heinemann Stella Flemmer Andrea Markowski Costantina Manes Matthias J. Bahr Hermann Haller Arnold vo | 2010 | Circulation2010，，1： | 1 |
| 10 | Factors Influencing Viral Clearing and Renal Function During Polyomavirus BK–Associated Nephropathy After Renal Transplantation显示文摘 | Anke Schwarz Silvia Linnenweber-Held Albert Heim Verena Br?cker Daniela Rieck Theodor Framke Lubna Raggub Hermann Haller | 2012 | Transplantation Journal2012，，4： | 1 |
| 11 | Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase显示文摘 | Ulf Landmesser Niels Engberding Ferdinand H. Bahlmann Arnd Schaefer Antje Wiencke Andre Heineke Stephan Spiekermann Denise Hilfiker-Kleiner Christian Templin Daniel Kotlarz Maja Mueller Martin Fuchs Burkhard Hornig Hermann Haller Helmut Drexler | 2004 | Circulation2004，，14： | 1 |
| 12 | Catheter-Based Renal Nerve Ablation and Centrally Generated Sympathetic Activity in Difficult-to-Control Hypertensive Patients: Prospective Case Series显示文摘 | Julia Brinkmann Karsten Heusser Bernhard M. Schmidt Jan Menne Gunnar Klein Johann Bauersachs Hermann Haller Fred C. Sweep Andre Diedrich Jens Jordan Jens Tank | 2012 | Hypertension2012，，6： | 1 |
| 13 | Effekte der antihypertensiven Langzeittherapie mit Losartan auf den Blutdruck und die kognitive Funktion bei Patienten mit essentieller Hypertonie und weiteren zerebrovaskul?ren Risikofaktoren (AWARE-Beobachtungsstudie)显示文摘 | Prof. Dr. Jürgen Schrader Stephan Lüders Hans-Christoph Diener Hermann Haller Roland E. Schmieder Klaus Wahle Wenefrieda Smolka Claudia Jung Kurt Bestehorn | 2008 | Medizinische Klinik2008，，7： | 1 |
| 14 | Carotid Baroreceptor Stimulation, Sympathetic Activity, Baroreflex Function, and Blood Pressure in Hypertensive Patients显示文摘 | Karsten Heusser Jens Tank Stefan Engeli André Diedrich Jan Menne Siegfried Eckert Tim Peters Fred C.G.J. Sweep Hermann Haller Andreas M. Pichlmaier Friedrich C. Luft Jens Jordan | 2010 | Hypertension2010，，3： | 1 |
| 15 | Antiinflammatory effects of angiotensin Ⅰ subtype 1 receptor blockade in hypertensive patients with microinflammation显示文摘 | Konrad Bucholz Hermann Haller | 2004 | Circulation2004，110，9： | 1 |
| 16 | Novel Baroreflex Activation Therapy in Resistant Hypertension显示文摘 | Ingrid J.M. Scheffers Abraham A. Kroon Jürg Schmidli Jens Jordan Jan J.M. Tordoir Markus G. Mohaupt Friedrich C. Luft Hermann Haller Jan Menne Stefan Engeli Jiri Ceral Siegfried Eckert Andrejs Erglis Krzysztof Narkiewicz Thomas Philipp Peter W. de Leeuw | 2010 | Journal of the American College of Cardiology2010，，15： | 1 |
| 17 | Urokinase Receptor Associates With Myocardin to Control Vascular Smooth Muscle Cells Phenotype in Vascular Disease显示文摘 | Yulia Kiyan Anne Limbourg Roman Kiyan Sergey Tkachuk Florian P. Limbourg Aleksandr Ovsianikov Boris N. Chichkov Hermann Haller Inna Dumler | 2012 | Arteriosclerosis Thrombosis and Vascular Biology2012，，1： | 1 |
| 18 | A Comparison of the Outcome of Pregnancies After Liver and Kidney Transplantation显示文摘 | Cornelia Blume Ayberk Sensoy Mechthild M. Gross Heinrich H. Guenter Hermann Haller Michael P. Manns Anke Schwarz Frank Lehner Juergen Klempnauer Sven Pischke Christian P. Strassburg | 2013 | Transplantation Journal2013，，1： | 1 |
| 19 | Catheter-Based Renal Nerve Ablation and Centrally Generated Sympathetic Activity in Difficult-to-Control Hypertensive Patients: Prospective Case Series显示文摘 | Julia Brinkmann Karsten Heusser Bernhard M. Schmidt Jan Menne Gunnar Klein Johann Bauersachs Hermann Haller Fred C. Sweep Andre Diedrich Jens Jordan Jens Tank | 2012 | Hypertension2012，，6： | 1 |
| 20 | Amelioration of Angiotensin II–Induced Cardiac Injury by a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor显示文摘 | Ralf Dechend Anette Fiebeler Joon-Keun Park Dominik N. Muller Juergen Theuer Eero Mervaala Markus Bieringer Dietrich Gulba Rainer Dietz Friedrich C. Luft Hermann Haller | 2001 | Circulation: Journal of the American Heart Association2001，，5： | 1 |
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