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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | The role of oxidative stress in the pathogenesis of age-related macular degeneration 显示文摘 | Beatty S Koh H Phil M Henson D Boulton M | 2000 | Surv Ophthalmol2000，45，2： | 1 |
| 3 | The role of fungal symbioses in the adaptation of plant to high stress environments显示文摘 | RODRIGUEZ R J REDMAN R S HENSON J M | 2004 | Mitigat Adaptat Strateg Glob Change2004，9，3： | 1 |
| 4 | Memory encryption : a survey of existing tech-niques显示文摘 | Henson M Taylor S | 2014 | ACM Computing Surveys2014，46，4： | 1 |
| 5 | The role of oxidative stress in the pathogenesis of age-related macular degeneration显示文摘 | BEATTY S KOH HfPHIL M HENSON D BOULTON M | 2000 | Surv Ophthalmol2000，45，2： | 1 |
| 6 | Nonlinear State Estimation and Model Predictive Control of Nitrogen Purification Columns 显示文摘 | BIAN S HENSON M A BELANGER P | 2005 | Industrial and Engineering Chemistry Research2005，44，1： | 1 |
| 7 | Compartmental Modeling of High Purity Air Separation Columns显示文摘 | BIAN S KHOWINIJIA S HENSON M A | 2005 | Computers and Chemical Engineering2005，29，： | 1 |
| 8 | Hierarchical models of intra-specific competition: scramble versus contest 显示文摘 | Henson S M Cushing J M | 1996 | J Math Biol1996，34，： | 1 |
| 9 | Algebraic multigfid based on element interpolation (AMGe)显示文摘 | Brezina M Cleary A J Falgout R D Henson V E Jones J E Manteuffel T A McCormick S F Ruge J W | 2000 | Journal of Scientific Computing2000，22，5： | 1 |
| 10 | Thermotolerance generated by plant/fungal symbiosis 显示文摘 | Redman R S Sheehan K B Stout R G Redriguez R J Henson J M | 2002 | Science2002，298，5598： | 1 |
| 11 | Biomarkers for early detection of colon cancer显示文摘 | Verma M Henson DE | 2001 | Clin Cancer Res2001，7，5： | 1 |
| 12 | Neutrophil sequestration and migration in localized pulmonary inflammation 显示文摘 | Downey G P Worthen G S Henson P M | 1993 | Ann Rev Respir Dis1993，147，： | 1 |
| 13 | Starchgranule distribution between cell types of alfalfa nodules as affected by symbiotic development 显示文摘 | HOSTAK M S HENSON C A DUCK S H | 1986 | Can J Bot1986，，65： | 1 |
| 14 | Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression显示文摘 | Manczak M Anekonda T S Henson E | 2006 | Hum Mol Genet2006，15，9： | 1 |
| 15 | The role of oxidative stress in the pathogenesis of age-relat- ed macular degeneration 显示文摘 | BEATTY S KOH HH PHIL M HENSON D BOULTON M | 2000 | Surv Ophthalmol2000，45，2： | 1 |
| 16 | Genetic regulation of fate decisions in therapeutic T cells to enhance tumor protection and memory formation显示文摘 | Velica P Zech M Henson S | 2015 | Cancer Res2015，75，13： | 1 |
| 17 | The role of fungal synbioses in the adaptation of plant to high stress environments 显示文摘 | Rodriguez R J Redman R S Henson J M | 2004 | Mitigation and Adaptation Strategies for Global Change2004，9，3： | 1 |
| 18 | Biomarkers for early detection of colon cancer 显示文摘 | Srivastava S Vemra M Henson DE | 2001 | Clin Cancer Res2001，7，5： | 1 |
| 19 | Decreased Expression of miR-125b and miR-100 in Oral Cancer Cells Contributes to Malignancy 显示文摘 | Henson B J Bhattacharjee S O'dee D M | 2009 | Genes Chromosomes & Cancer2009，48，7： | 1 |
| 20 | ABA,hydrogen peroxide and nitric oxide signaling in stomatal guard cells显示文摘 | DESIKAN R CHEUNG M K BRIGHT J HENSON D HANCOCK J T NEILL S J | 2004 | Journal of Experimental Botany2004，55，： | 1 |
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