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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Left ventricular contractility is impaired following myocardial infarction in the pig and rat:assessment by the end systolic pressure-volume relation using a singlebeat estimation technique and cine magnetic resonance显示文摘 | Setser R Henson RE Allen JS | 2000 | Imaging Ann Biomed Eng2000，28，5： | 1 |
| 3 | MieroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatoeel- lular cancer显示文摘 | Meng F Henson R Wehbe-Janek H | 2007 | castroenterology2007，133，2： | 1 |
| 4 | A reliability generalization study of the teacher efficacy scale and related instruments 显示文摘 | Henson R K Kogan L R Vacha-Haase T | 2001 | Educational and Psychological Measurement2001，61，3： | 1 |
| 5 | Male and female alternative reproductive behaviors in fishes: a new approach using intersexual dynamies显示文摘 | HENSON S A WARNER R R | 1997 | Annual Review of Ecology and Systematics1997，28，： | 1 |
| 6 | Differential trends in the intestinal and diffuse types of gastric carcinoma in the United States,1973-2000显示文摘 | Henson D R Dittus C Younes M | 2004 | Arch Pathol Lab Med2004，128，7： | 1 |
| 7 | Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines显示文摘 | Meng F Henson R Lang M | 2006 | Gastroenterology2006，130，7： | 1 |
| 8 | Selection of model parameters for off-line parameter estimation显示文摘 | Li R Henson M A Kurtz M J | 2004 | 1EEE Trans on Control Systems Technology2004，12，3： | 1 |
| 9 | Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression显示文摘 | Wehbe H Henson R Meng F | | 0，，21： | 1 |
| 10 | Rap1 mediates galaninreceptor 2-induced proliferation and survival in squamous cellcarcinoma显示文摘 | Banerjee R Henson BS Russo N | 2011 | Cellular Signalling2011，23，7： | 1 |
| 11 | The procell death bcl-2 family member,BNIP3,is localized to the nucleus of human glialcells:implications for glioblastoma multiforme tumor cells urvival under hypoxia显示文摘 | HENSON E S BAIJAL P | 2006 | Int J Cancer2006，118，7： | 1 |
| 12 | MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer 显示文摘 | Meng F Henson R Wehbe-Janek H | 2007 | Gastroenterology2007，133，2： | 1 |
| 13 | Tissue injury in inflammation:oxidants,proteinases,and cationic proteins显示文摘 | HENSON P M JOHNSTON R B | 1987 | Clin Invest1987，79，： | 1 |
| 14 | Alzheimer's patients engage an alternative network during a memory task显示文摘 | PARIENTE J COLE S HENSON R | 2005 | Ann Neurol2005，58，6： | 1 |
| 15 | MicroRNA- 21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer显示文摘 | MENG F HENSON R WEHBE JANEK H | 2007 | Gastroenterology2007，133，2： | 1 |
| 16 | The role of fungal symbioses in the adaptation of plant to high stress environments显示文摘 | RODRIGUEZ R J REDMAN R S HENSON J M | 2004 | Mitigat Adaptat Strateg Glob Change2004，9，3： | 1 |
| 17 | MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer 显示文摘 | Meng F Henson R Wehbe-Janek H | 2007 | Gastroenterology2007，133，2： | 1 |
| 18 | MicroRNA-21 regu- lates expression of the PTEN tumor suppressor gene in human bepa- tocellular cancer 显示文摘 | Meng F Henson R Wehbc-Janck H | 2007 | Gastroenterology2007，133，2： | 1 |
| 19 | Scopolamine but not lorazepam modulates face repetition priming: A psychopharmacological fMR1 study显示文摘 | Thiel C M Henson R N A Dolan R J | 2002 | Neuropsychopharmacology2002，27，2： | 1 |
| 20 | MicroRNA-21 regulatesexpression of the PTEN tumor suppressor gene in humanhepatocellular cancer显示文摘 | Meng F Henson R Wehbe-Janek H | 2007 | Gastroenterology2007，133，2： | 1 |
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