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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | A reliability generalization study of the teacher efficacy scale and related instruments 显示文摘 | Henson R K Kogan L R Vacha-Haase T | 2001 | Educational and Psychological Measurement2001，61，3： | 1 |
| 3 | Development of functional diversity in mouse macrophage,Mutual exclusion of two phenotypic states显示文摘 | HENSON PM WEINSTEIN L | 1993 | Am J Pathol1993，143，4： | 1 |
| 4 | Evaluation of Heated Solutions of Sulfur Dioxide, Ethanol, and Hydrogen Peroxide to Control Postharvest Green Mold of Lemons 显示文摘 | SMILANICK J L MARGOSAN D A HENSON D J | 1995 | Plant Dis1995，，79： | 1 |
| 5 | Hierarchical load hindcasting using reanalysis weather显示文摘 | Black J D Henson W L W | 2014 | IEEE Transactions on Smart Grid2014，5，1： | 1 |
| 6 | Moisture diffusion in the cured hurley tobacco leaf 显示文摘 | Walton L R Henry Z A Henson W H | 1976 | Transactions of the ASA- BE1976，19，4： | 1 |
| 7 | Evaluation of heated solutions of sulfur dioxide, ethanol, and hydrogen peroxide to control postharvest green mold of lemons 显示文摘 | Smilanick J L Margosan D A Henson D J | 1995 | Plant Disease1995，79，： | 1 |
| 8 | Imaging and microanalyses of mercury in flood plain soils of east fork poplar creek显示文摘 | Harris L A Henson T J | 1996 | Water Air and Soil Pollution1996，86，： | 1 |
| 9 | Diffusion of moisture from burley tobacco leaves during curing 显示文摘 | Walton L R Casada M E Henson W H | 1982 | Transactions of the ASABE1982，25，4： | 1 |
| 10 | A reliability generaliza- tion study of the teacher efficacy scale and related instruments显示文摘 | Henson R K Kogan L R Vacha-Haase T | 2001 | Educational and Psychological Measurement2001，61，： | 1 |
| 11 | Neutrophilendothelial cell interactions显示文摘 | TONNESEN M G SMEDLY L A HENSON P M | 1984 | J Clin Inbest1984，74，6： | 1 |
| 12 | A reliability generalization study of the teacher efficacy scale and related instruments 显示文摘 | Henson R K Kogan L R Vacha-Haase T | 2001 | Educa-fional and Psychological Measurement2001，61，3： | 1 |
| 13 | Measurement of Psychological Disorders Using Cognitive Diagnosis Models显示文摘 | Templin J L Henson R A | 2006 | Psychological Methods2006，11，3： | 1 |
| 14 | Dynamic modeling and linear model predictive control of gas pipeine networks显示文摘 | ZHU Guangyan HENSON M A MEGAN L | 2001 | Journal of Process Control2001，11，： | 1 |
| 15 | Simultaneous determination of enantioselective plasma protein binding of aminohvdantoins by ultrafiltration and chiral high performance liquid chromatography显示文摘 | PENG S X HENSON C WILSON L J | 1999 | J Chromatogr B1999，732，： | 1 |
| 16 | Gangliosides expressed on breast cancer cells are E-selectin ligands显示文摘 | Shirure V S Henson K A Schnaar R L | 2011 | Biochem Biophys Res Commun2011，406，42： | 1 |
| 17 | Inhibition of citral degradation in model beverage emulsions using micelles and reverse micelles显示文摘 | CHOI S j DECKER E A HENSON L | 2010 | Food Chemistry2010，122，1： | 1 |
| 18 | Kinetics of the δphase transition in PBX9501显示文摘 | Smilowitz L B Henson B F | 2001 | Shock Compression of Condensed Matter2001，620，： | 1 |
| 19 | The SSN ontology of the W3C semantic sensor network incubator group显示文摘 | Michael Compton Payam Barnaghi Luis Bermudez Raúl García-Castro Oscar Corcho Simon Cox John Graybeal Manfred Hauswirth Cory Henson Arthur Herzog Vincent Huang Krzysztof Janowicz W. David Kelsey Danh Le Phuoc Laurent Lefort Myriam Leggieri Holger Neuhaus A | 2012 | Web Semantics: Science Services and Agents on the World Wide Web2012，，： | 1 |
| 20 | Measurement of psychological dis- orders using cognitive diagnosis models显示文摘 | Templin J L Henson R A | 2006 | Psychological Meth- ods2006，11，3： | 1 |
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