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| 1 | Age and menopausal status are important factors influencing the serum human epididymis secretory protein 4 level:a prospective cross-sectional study in healthy Chinese people显示文摘Background::Human epididymis secretory protein 4(HE4)is a new ovarian cancer biomarker.The factors influencing HE4 levels are not clear,and the reference data in China are limited.Here,we aim to evaluate the effects of menopause and age on HE4 levels and to provide a possible reference value for HE4 in healthy Chinese people.Methods::A total of 2493 healthy females aged 40 years or older were recruited from March 2013 to March 2017 with the cooperation of four medical institutions across Beijing,China.The serum levels of HE4 and cancer antigen 125(CA125)were measured by enzyme-linked immunosorbent assay.The Wilcoxon rank-sum test of variance and a stratified analysis were used to analyze the relationships among age,menopausal status,and levels of HE4 or CA125.Confidence intervals(5%-95%)were determined for reference ranges in different populations.Results::There was a statistically significant difference in median HE4 levels between the post-menopausal(n=2168)and premenopausal groups(n=325)(36.46 vs.24.04 pmol/L,Z=-14.41,P<0.001).HE4 increased significantly with age in the post-menopausal groups(H=408.18,P<0.001)but not in the pre-menopausal subjects(Z=-0.43,P=0.67).The upper 95th percentile of HE4 levels were 44.63 pmol/L for pre-menopausal women,78.17 pmol/L for post-menopausal women,and 73.3 pmol/L for all women.In the post-menopausal population,the HE4 reference ranges were 13.15 to 47.31,14.31 to 58.04,17.06 to 73.51,24.50 to 115.25,and 35.71 to 212.37 pmol/L for different age groups from forty divided by decade.The CA125 level was affected mainly by menopausal status and not age.Conclusions::Menopausal status and age were both important factors influencing the level of HE4,and age affected HE4 levels mainly in post-menopausal women.The HE4 level was higher in the post-menopausal population than in the pre-menopausal population and increased with age. | Hong-Yan Cheng Lin Zeng Xue Ye Rui-Qiong M a Zhi-Jian Tang Hong-Ling Chu Yi-M ing Zhao Li-Rong Zhu Yu-Nong Gao Xiao-Hong Chang Heng Cui | 2020 | Chinese Medical Journal2020，，11： | 6 |
| 2 | Rotating machinery prognostics : State of the art, challenges and opportunities显示文摘 | Heng A Zhang S Tan A C C | 2009 | Mechanical Systems and Signal Processing2009，23，3： | 1 |
| 3 | A Hap-tic Needle Manipulation Simulator for Chinese Acupuncture Learning and Training显示文摘 | Heng P A Wong T T Leung K M | 2006 | International Journal of Image and Graphics2006，6，2： | 1 |
| 4 | Fuzzy numbers and fuzzification of Choquet integrals显示文摘 | RONG Yang WANG Zhenyuan PHENG ANN HENG A | 2005 | Fuzzy Sets and Systems2005，153，： | 1 |
| 5 | Chinese Visible Human Project显示文摘 | Zhang S X Heng P A Liu Z J | 2006 | Clin Anat2006，19，3： | 1 |
| 6 | Chinese Visible Human Project: the Present and Future 显示文摘 | Zhang S X Heng P A Liu Z J | 2006 | Clinical Anatomy2006，19，3： | 1 |
| 7 | Fuzzified Choquet integral with fuzzy-valued integrandand its application on temperature prediction显示文摘 | RONG Yang WANG Zhenyuan PHENG ANN HENG A | 2008 | IEEE T SMCB2008，38，2： | 1 |
| 8 | Shape matching and modeling using skeletal context显示文摘 | Xie J Heng P A Shah M | | 0，，05： | 1 |
| 9 | An improved scheme of an interactive finite element model for 3D soft-tissue cutting and deformation 显示文摘 | WU W HENG P A | 2005 | Visual Computer2005，21，5： | 1 |
| 10 | Intelligent condition based prediction of machinery reliability显示文摘 | Heng A Tan A C C Mathew J | 2009 | Mechanical Systems and Signal Processing2009，23，5： | 1 |
| 11 | Chinese visible human project 显示文摘 | Zhang S X Heng P A Liu Z J | 2006 | Clin Anat2006，19，3： | 1 |
| 12 | Isosurface computation for approximating boundary surfaces in 3D images显示文摘 | Wang L Bai J Heng P A | 2007 | Journal of Electronic Imaging2007，16，1： | 1 |
| 13 | The Chinese Visible Human (CVH) datasets incorporate technical and imaging advances on earlier digital humans显示文摘 | Zhang S X Heng P A Liu Z J | 2004 | J Anat2004，204，3： | 1 |
| 14 | Alcoholysis of palm oil mid-fraction by lipase from Rhizopus rhizopodiformis显示文摘 | Basri M Heng A C Razak C A N | 1997 | Journal of Ameriean Oil Chemists'' Society1997，74，2： | 1 |
| 15 | Rotating machinery prognostics: state of the art, challenges and opportunities 显示文摘 | Heng A Zhang S Tan A C C | 2009 | Mechanical Systems and Signal Processing2009，23，3： | 1 |
| 16 | Rotating Machinery Prognostics:State of the Art,Challenges and Opportunities显示文摘 | Heng A Zhang S Tan A | 2008 | Mechanical Systems and Signal Processing2008，23，3： | 1 |
| 17 | Fuzzy Numbers and Fuzzification of the Choquet Integral 显示文摘 | YANGR WANG Z Y HENG P A | 2005 | Fuzzy Sets and Systems2005，151，1： | 1 |
| 18 | Chinese visible human project显示文摘 | Zhang S X Heng P A Liu Z J | 2006 | Clin Anat2006，19，3： | 1 |
| 19 | Photorealistic virtual anatomy based on Chinese Visible Human data显示文摘 | Heng P A Zhang S X Xie Y M | 2006 | Clin Anat2006，19，3： | 1 |
| 20 | Chinese visible human project显示文摘 | Zhang S X Heng P A Liu Z J | 2006 | Clinical Anatomy2006，19，3： | 1 |
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