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| 1 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 3 | Absence of alpha4 but not beta2 integrins restrains development of chronic allergic asthma using mouse genetic models 显示文摘 | Banerjee ER Jiang Y Henderson WR | 2009 | Exp Hematol2009，37，6： | 1 |
| 4 | Quantification of Halocene Asian monsoon rainfall from spatially separated cave record 显示文摘 | Hu C Y Henderson G M Huang J H | 2008 | Earth Planet Sci Lett2008，266，： | 1 |
| 5 | Neuroectodermal differentiation from mouse multipotent adult progenitor cells 显示文摘 | Jiang Y Henderson D Blackstad M | 2003 | Proc Natl Acad Sci2003，100，1： | 1 |
| 6 | Quantification of Holocene Asian monsoon rainfall from spatially separated cave records显示文摘 | Hu C Y Henderson G M Huang J H | 2008 | Earth and Planetary Science Letters2008，266，： | 1 |
| 7 | Flow-boiling heat transfer of R - 134a-based nanofluids in a horizontal tube 显示文摘 | HENDERSON K PARK Y G LIU L | 2010 | International Journal of Heat and Mass Transfer2010，53，56： | 1 |
| 8 | The contrast mechanism for true atomic resolution by AFM in non-contact mode: quasi-non-contact mode显示文摘 | Sokolov I Y Henderson G S Wicks F J | 1997 | Surface Science1997，381，： | 1 |
| 9 | Transcending the 'here' : The effect of spatial distance on social judgment 显示文摘 | Fujita K Henderson M D Trope Y | 2006 | Journal of Personality and Social Psychology2006，91，5： | 1 |
| 10 | An orthotopic model of papillary thyroid carcinoma in athymic nude mice显示文摘 | Ahn SH Henderson Y Kang Y | 2008 | Arch Otolaryngel Head Neck Surg2008，134，2： | 1 |
| 11 | High rate of BRAF and RET/PTC dual mutations associated with re current papillary thyroid carcinoma显示文摘 | Henderson Y C Shellenberger T D Williams M D | 2009 | Clin Cancer Res2009，15，2： | 1 |
| 12 | Sorafenib (BA Y 439006) inhibits tumor growth and vascularization and induces tumor apopto?sis and hypoxia in RCC xenograft models显示文摘 | Chang Y S AdnaneJ Trail P A LevyJ Henderson A Xue D | 2007 | Cancer Chemother Pharmacol2007，59，56： | 1 |
| 13 | Olfactory deficits and sleep disturbances in Parkinson's disease: a case-control survey 显示文摘 | Henderson JM Lu Y Wang S | 2003 | J Neurol Neurosurg Psychiatry2003，74，： | 1 |
| 14 | Quantification ofHolocene Asian monsoon rainfall from spatially separated caverecords显示文摘 | Hu C Y Henderson G M Huang J H | 2008 | Earth and Planetary Science Letters2008，266，： | 1 |
| 15 | Simultaneous Strain, Temperature and Vibration Measurement Using a Multiplexed in-Fiber-Bragg-Gratirg/Fiber-Fabry-Perot Sensor System显示文摘 | Rao Y J Henderson P J Jackson D A Zhang L Bennion I | 1997 | Electron Lett1997，，23： | 1 |
| 16 | Mothers' anxiety during pregnancy is associated with asthma in their children显示文摘 | Cookson H Granell R Joinson C Ben-Shlomo Y Henderson AJ | | 0，，： | 1 |
| 17 | Quantification of Holocene Asian monsoon rainfall from spatially separated cave record 显示文摘 | Hu C Y Henderson G M Huang J H | 2008 | Earth Planet Sci Lett2008，266，： | 1 |
| 18 | A Model of Housing TenureChoice 显示文摘 | Henderson V Ioannides Y | 1983 | American Economic Review1983，73，： | 1 |
| 19 | MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo显示文摘 | Henderson YC Chen Y Frederick MJ | 2010 | Mol Cancer Ther2010，9，7： | 1 |
| 20 | Stabilimax NZ versus simulated fusion:evaluation of adjacent-level effects 显示文摘 | Panjabi MM Henderson G James Y | 2007 | Eur Spine J2007，16，12： | 1 |
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