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| 1 | Targeting the tumor stroma in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common and deadly cancers worldwide. In ninety percent of the cases it develops as a result of chronic liver damage and it is thus a typical inflammationrelated cancer characterized by the close relation between the tumor microenvironment and tumor cells. The stromal environment consists out of several cell types, including hepatic stellate cells, macrophages and endothelial cells. They are not just active bystanders in the pathogenesis of HCC, but play an important and active role in tumor initiation, progression and metastasis. Furthermore, the tumor itself influences these cells to create a background that is beneficial for sustaining tumor growth. One of the key players is the hepatic stellate cell, which is activated during liver damage and differentiates towards a myofibroblast-like cell. Activated stellate cells are responsible for the deposition of extracellular matrix, increase the production of angiogenic factors and stimulate the recruitment of macrophages. The increase of angiogenic factors(which are secreted by macrophages, tumor cells and activated stellate cells) will induce the formation of new blood vessels, thereby supplying the tumor with more oxygen and nutrients, thus supporting tumor growth and offering a passageway in the circulatory system. In addition, the secretion of chemokines by the tumor cells leads to the recruitment of tumor associated macrophages. These tumor associated macrophages are key actors of cancer-related inflammation, being the main type of inflammatory cells infiltrating the tumor environment and exerting a tumor promoting effect by secreting growth factors, stimulating angiogenesis and influ-encing the activation of stellate cells. This complex interplay between the several cell types involved in liver cancer emphasizes the need for targeting the tumor stroma in HCC patients. | Femke Heindryckx Pär Gerwins | 2015 | World Journal of Hepatology2015，7，2： | 16 |
| 2 | Treatment option for sperm-or oocyte-related fertilization failure :assisted oovyte activation following diagnositic heterologous ICSI显示文摘 | Heindryckx B Vander J Elst De Sutter P | 2005 | Hunman Reproduction2005，20，8： | 1 |
| 3 | Experimental mouse models for hepatocellular carcinoma research显示文摘 | Heindryckx F Colle I Van Vlierberghe H | 2009 | Int J Exp Pathol2009，90，4： | 1 |
| 4 | Angiogenesis in chronic liver disease and its complications 显示文摘 | Coulon S Heindryckx F Geerts A | 2011 | Liver Int2011，31，2： | 1 |
| 5 | Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease显示文摘 | Stephanie Coulon Sven Francque Isabelle Colle An Verrijken Bram Blomme Femke Heindryckx Steffi De Munter Janne Prawitt Sandrine Caron Bart Staels Hans Van Vlierberghe Luc Van Gaal Anja Geerts | 2012 | Cytokine2012，，： | 1 |
| 6 | Treatment option for sperm-or oocyte-related fertilization failure:assisted oocyte activation following diagnostic heterologous ICSI显示文摘 | Heindryckx B Van der Elst J De Sutter P | 2005 | Hum Reprod2005，20，8： | 1 |
| 7 | Treatment option for sperm-or oocyte-related fertilization failure: assisted oovyte acti- vation following diagnnsitic heteroh,gous ICSI显示文摘 | Heindryckx B Vander J Elst De Sutter P | 2005 | Hunman Repro- ducti m2005，20，8： | 1 |
| 8 | Serial pronuclear transfer increases the developmental potential of in vitro-matured oocytes in mouse cloning显示文摘 | Heindryckx B Rybouchkin A Van Der EJ | 2002 | Biol Reprod2002，67，6： | 1 |
| 9 | Effect of culture media on in vitro development of cloned mouse embryos显示文摘 | Heindryckx B Rybouchkin A Van Der Elst J | 2001 | Cloning2001，3，2： | 1 |
| 10 | Oocyte activation, phospholipase C zeta and human infertility 显示文摘 | Kashir J Heindryckx B Jones C | 2010 | Hum Reprod Update2010，16，6： | 1 |
| 11 | Further pharmacological and genetic evidence for the effi cacy of PLGF inhibition in cancer and eye disease显示文摘 | Van de Veire S Stalmans I Heindryckx F | | 0，，： | 1 |
| 12 | Oocyte activation, phospholipase C zeta and human infertility 显示文摘 | Kashir J Heindryckx B Jones C | 2010 | Hum Reprod Update2010，16，6： | 1 |
| 13 | Angiogenesis in chronic liver disease and its complications显示文摘 | Coulon S Heindryckx F Geerts A | | 0，，： | 1 |
| 14 | Oocyte activation, phospholipase C zeta and human infertility 显示文摘 | Kashir J Heindryckx I3 Jones C | 2010 | Hum Reprod Update2010，16，6： | 1 |
| 15 | Treatment option for sperm- or oocyte-related fertilization failure : assisted oocyte activation following diagnostic heterologous ICSI 显示文摘 | Heindryckx B Van der Elst J De Sutter P | 2005 | Hum Reprod2005，20，： | 1 |
| 16 | Angiogenesis inchronic liver disease and its complications 显示文摘 | Coulon S Heindryckx F Geerts A | | Liver Int0，，： | 1 |
| 17 | Serial pronuclear transfer increases the developmental potential of in vitro-matured oocytes in mouse cloning显示文摘 | Heindryckx B Rybouchkin A Van der E J | 2002 | Biol Reprod2002，67，： | 1 |
| 18 | Experimental mouse models for hepatocellular carcinoma research显示文摘 | Heindryckx F Colle I Van Vlierberghe H | 2009 | Int J Exp Pathol2009，90，4： | 1 |
| 19 | Treatment option for sperm-or oocyte-related fertilization failure:assisted oocyte activation following diagnostic heterologous ICSI显示文摘 | Heindryckx B Van der Elst J De Sutter P | 2005 | Hum Reprod2005，20，8： | 1 |
| 20 | Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease显示文摘 | Stephanie Coulon Sven Francque Isabelle Colle An Verrijken Bram Blomme Femke Heindryckx Steffi De Munter Janne Prawitt Sandrine Caron Bart Staels Hans Van Vlierberghe Luc Van Gaal Anja Geerts | 2012 | Cytokine2012，，2： | 1 |
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