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| 1 | Probiotic bacteria change Escherichia coli-induced gene expression in cultured colonocytes:Implications in intestinal pathophysiology显示文摘AIM: To investigate the change in eukaryotic gene expression profile in Caco-2 cells after infection with strains of Escherichia coli and commensal probiotic bacteria. METHODS: A 19 200 gene/expressed sequence tag gene chip was used to examine expression of genes after infection of Caco-2 cells with strains of normal flora E. coli,Lactobacillus plantarum,and a combination of the two. RESULTS: The cDNA microarray revealed up-regulation of 155 and down-regulation of 177 genes by E. coli . L. plantarum up-regulated 45 and down-regulated 36 genes. During mixed infection,27 genes were up-regulated and 59 were down-regulated,with nullification of stimulatory/inhibitory effects on most of the genes. Expression of several new genes was noted in this group. CONCLUSION: The commensal bacterial strains used in this study induced the expression of a large number of genes in colonocyte-like cultured cells and changed the expression of several genes involved in important cellular processes such as regulation of transcription,protein biosynthesis,metabolism,cell adhesion,ubiquitination,and apoptosis. Such changes induced by the presence of probiotic bacteria may shape the physiologic and pathologic responses they trigger in the host. | Pinaki Panigrahi Gheorghe T Braileanu Hegang Chen O Colin Stine | 2007 | World Journal of Gastroenterology2007，13，47： | 10 |
| 2 | APOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome 1显示文摘 | Michael Miller Jeffrey Rhyne Hegang Chen Valerie Beach Richard Ericson Kalpana Luthra Manjari Dwivedi Anoop Misra | 2007 | Archives of Medical Research2007，，4： | 1 |
| 3 | APOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome 1显示文摘 | Michael Miller Jeffrey Rhyne Hegang Chen Valerie Beach Richard Ericson Kalpana Luthra Manjari Dwivedi Anoop Misra | 2007 | Archives of Medical Research2007，，4： | 1 |
| 4 | Effect of internal Lewis base on active site distribution for ethylene/1-octene copolymerization by TiCl4/Lewis base/MgCl2 catalysts显示文摘 | Wang Euhai Yang Min Ren Hegang | 2010 | Macromolecular Research2010，18，1： | 1 |
| 5 | N-Terminal Pro-B-Type Natriuretic Peptide and B-Type Natriuretic Peptide for Identifying Coronary Artery Disease and Left Ventricular Hypertrophy in Ambulatory Chronic Kidney Disease Patients显示文摘 | Ijaz A. Khan Jeffrey Fink Caitlin Nass Hegang Chen Robert Christenson Christopher R. deFilippi | 2006 | The American Journal of Cardiology2006，，10： | 1 |
| 6 | ThestatusquoandprospectsofplantingannualryegrassinwinterfallowfieldsofShuicheng[J]显示文摘 | HETianli(何天丽) HEGang(何刚) | | 农技服务0，，： | 1 |
| 7 | 2^n-l designs with weak minimum aberration显示文摘 | Chen Hegang Hedayat A S | 1996 | Ann Statist1996，24，： | 1 |
| 8 | 2n-m designs with resolution or containing clear two-factor interactions显示文摘 | CHEN Hegang Hedayat A S | 1998 | Journal of Statistical Planning and Inference1998，75，1： | 1 |
| 9 | AN INTERACTIVE APPROACH TO READING显示文摘Introduction The Sino-British Friendship Scholarship Scheme (SBFSS) is co-sponsored by the Chinese and British governments and Sir Yue-gang Pao in Hong Kong to send Chinese scholars to study in Britain. Each year a large number of candidates are selected by the State Education Commission and dispatched to three intensive language training centres attached to Beijing Languages Institute, Shanghai Foreign Studies University and Chengdu University of Science and Technology for pre-departure ELT training. At the end of the training period, the trainees are required to take the International English Language Testing System (IELTS) test administered by the British side. Here at CUST, we focus on an interactive approach to training, particularly for reading. | Deng Hegang Chengdu University of Science and Technology | 1994 | Chinese Journal of Applied Linguistics1994，18，0： | 0 |
| 10 | Advances in Mathematical Modeling of NFκB Signal Transduction in Mammals显示文摘NFκB is a basic transcription factor of cell signal transduction in mammals. Mathematical modeling can be used to simulate NFκB signal transduction and investigate the molecular mechanism. The initial IκB-NFκB signal transduction model emphasized the effects of negative feedback on NFκB temporal dynamics and gene expression control,while subsequent studies are concentrated on other feedback loops,input-output behaviors of modules,crosslinking of several NFκB activation paths and NFκB oscillation. Computer technology will continue to contribute to studies of NFκB signaling pathway. Finally,several potential development trends were discussed in this paper. | Jinshan ZHAO Ke JIANG Zhenghao DAI Xiaoli REN Yumei WANG Yongping JIANG Mingtuan LIU Yonglian DAI Lele HOU Hegang LI | 2013 | Agricultural Biotechnology2013，2，4： | 0 |
| 11 | Application of Artificially Induced Double-strand Breaks (DSB) and Triplex-forming Oligonucleotides (TFO) in the Improvement of Gene Targeting Efficiency显示文摘Gene targeting technology is an important means to investigate gene functions,but its efficiency of gene targeting is very low,especially for somatic cell targeting. Artificially induced double-strand breaks (DSB) and triplex forming oligonucleotide (TFO) are currently developed methods to improve the targeting efficiency. This paper summarized the basic principles,design ideas and application in gene targeting efficiency improvement of these two methods,analyzed and compared their characteristics,and finally proposed prospects for their future development. | Hegang LI Wenke CHENG Ke JIANG Xiaoli REN Yongping JIANG Lele HOU Xiaojing HAO Jinshan ZHAO | 2013 | Agricultural Biotechnology2013，2，1： | 0 |
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