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| 1 | Radiotherapy as valid modality for hepatocellular carcinoma with portal vein tumor thrombosis显示文摘Although the current standard treatment for hepatocellular carcinoma(HCC) with portal vein tumor thrombosis(PVTT) is sorafenib, many previous studies have established the need for a reliable local modality for PVTT control, which is a major cause of liver function deterioration and metastasis. Additionally, there is growing evidence for the prognostic significance of PVTT classification according to the location of tumor thrombosis. Favorable outcomes can be obtained by applying local modalities, including surgery or transarterial chemoembolization, especially in second-order or distal branch PVTT. Rapid control of PVTT could maintain or improve liver function and reduce intrahepatic as well as distant metastasis. Radiotherapy(RT) is one of the main locoregional treatment modalities in oncologic fields, but has rarely been used in HCC because of concerns regarding hepatic toxicity. However, with the development of advanced techniques, RT has been increasingly applied in HCC management. Randomized studies have yet to definitively prove the benefit of RT, but several comparative studies have justified the application of RT in HCC. The value of RT is especially noticeable in HCC with PVTT; several prospective and retrospective studies have reported favorable outcomes, including a 40% to 60% objective response rate and median overall survival of 15 mo to 20 mo in responders. In this review, we evaluate the role of RT as an alternative local modality in HCC with PVTT. | Jeong Il Yu Hee Chul Park | 2016 | World Journal of Gastroenterology2016，22，30： | 20 |
| 2 | Proton therapy for hepatocellular carcinoma:Current knowledges and future perspectives显示文摘Hepatocellular carcinoma(HCC) is the second leading cause of cancer-related death, as few patients can be treated with currently available curative local modalities. In patients with HCC where curative modalities are not feasible, radiation therapy(RT) has emerged as an alternative or combination therapy. With the development of various technologies, RT has been increasingly used for the management of HCC. Among these advances, proton beam therapy(PBT) has several unique physical properties that give it a finite range in a distal direction, and thus no exit dose along the beam path. Therefore, PBT has dosimetric advantages compared with X-ray therapy for the treatment of HCC. Indeed, various reports in the literature have described the favorable clinical outcomes and improved safety of PBT for HCC patients compared with X-ray therapy. However, there are some technical issues regarding the use of PBT in HCC, including uncertainty of organ motion and inaccuracy during calculation of tissue density and beam range, all of which may reduce the robustness of a PBT treatment plan. In this review, we discuss the physical properties, current clinical data, technical issues, and future perspectives on PBT for the treatment of HCC. | Gyu Sang Yoo Jeong Il Yu Hee Chul Park | 2018 | World Journal of Gastroenterology2018，24，28： | 8 |
| 3 | 3-Dimensional liver volume assessment in patients with hepatitis B virus-related liver cirrhosis during long-term oral nucleos(t)ide analogues therapy显示文摘AIM To assess the effect of long-term oral nucleos(t)ide analogues(NUCs) therapy on liver volume change in patients with suppress hepatitis B virus(HBV)-related liver cirrhosis.METHODS We reviewed the data of na?ve patients with HBVrelated liver cirrhosis, who had taken oral NUCs therapy, between 2003 and 2007 at Chonbuk University Hospital. We analyzed two consecutive sets of abdominal computerized tomography scans-one at the time oftreatment initiation and another at the second-year follow-up. Liver volume was calculated by 3-dimensional liver extraction volumetry program.RESULTS A total of 55 patients(34 males) were included. There was 114.3 m L ± 167.8 m L(12.9% ± 17.9%) of increase in liver volume during the two years of NUCs therapy(993.8 m L ± 242.8 m L at baseline vs 1108.1 m L ± 263.3 m L at two-year follow-up, P < 0.001). The ratio of the measured baseline liver volume to the estimated standard liver volume was improved from 70.8% to 78.0%. An increase in liver volume was shown not only in patients with compensated cirrhosis(P = 0.046) but also in those with decompensated cirrhosis(P < 0.001). Significant factors for volume increases were Child-Turcotte-Pugh grade and model for end-stage liver disease score improvement without virological breakthrough. In multiple linear regression analysis, delta albumin and delta alanine aminotransferase levels showed a significant association with the increase in liver volume(P = 0.002 and 0.005, respectively).CONCLUSION Long-term oral NUCs therapy in patients with HBVrelated liver cirrhosis lead to significant increase in liver volume assessed with 3-dimensional liver extraction volumetry program. | Chang Hun Lee In Hee Kim Jin Chang Moon Seung Young Seo Seong Hun Kim Sang Wook Kim Seung Ok Lee Soo Teik Lee Dae Ghon Kim Jae Do Yang Hee Chul Yu | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 4 | The feasibility of combined transcatheter arterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma显示文摘 | Ju‐Yeon Cho Yong‐Han Paik Hee Chul Park Jeong Il Yu Won Sohn Geum‐Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2014 | Liver Int2014，，5： | 5 |
| 5 | Ischemic colitis secondary to inferior mesenteric arteriovenous fistula and portal vein stenosis in a liver transplant recipient显示文摘Arteriovenous fistula (AVF) involving the inferior mesenteric vessels is rare, and the affected patients usually present with abdominal pain, mass, or features of established portal hypertension. Colonic ischemia is a less common and more serious manifestation of AVF. We report a case of ischemic colitis secondary to inferior mesenteric AVF in a patient who underwent a previous liver transplantation, subsequently developed portal vein stenosis, and then presented with acute lower gastrointestinal bleeding. He underwent percutaneous transhepatic placement of a portal vein stent and left colectomy. | In Hee Kim Dae Ghon Kim Hyo Sung Kwak Hee Chul Yu Baik Hwan Cho Ho Sung Park | 2008 | World Journal of Gastroenterology2008，14，26： | 2 |
| 6 | A Prospective Randomized Controlled Study Comparing Outcomes of Standard Resection and Extended Resection, Including Dissection of the Nerve Plexus and Various Lymph Nodes, in Patients With Pancreatic Head Cancer显示文摘 | Jin-Young Jang Mee Joo Kang Jin Seok Heo Seong Ho Choi Dong Wook Choi Sang Jae Park Sung-Sik Han Dong Sup Yoon Hee Chul Yu Koo Jeong Kang Sang Geol Kim Sun-Whe Kim | 2014 | Annals of Surgery2014，，4： | 2 |
| 7 | Predictive factors for local recurrence after endoscopic resection for early gastric cancer: long-term clinical outcome in a single-center experience显示文摘 | Jun Chul Park Sang Kil Lee Ju Hee Seo Yu Jin Kim Hyunsoo Chung Sung Kwan Shin Yong Chan Lee | 2010 | Surgical Endoscopy2010，，11： | 2 |
| 8 | Seroprevalence of anti-HAV among patients with chronic viral liver disease显示文摘AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in Korea.We also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December 2009.RESULTS:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health Promotion.The anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver cirrhosis.The anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of age.Multivariable analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus. | Hyun Chin Cho Seung Woon Paik Yu Jin Kim Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Byung Chul Yoo Hee Jung Son Seon Woo Kim | 2011 | World Journal of Gastroenterology2011，17，2： | 1 |
| 9 | Variable phenotype of Pierson syndrome显示文摘 | Hyun Jin Choi Beom Hee Lee Ju Hyung Kang Hyoen Joo Jeong Kyung Chul Moon Il Soo Ha Young Suk Yu Verena Matejas Martin Zenker Yong Choi Hae Il Cheong | 2008 | Pediatric Nephrology2008，，6： | 1 |
| 10 | Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses显示文摘 | Yanyan Yang Seung Cheol Kim Tao Yu Young-Su Yi Man Hee Rhee Gi-Ho Sung Byong Chul Yoo Jae Youl Cho Pham My-Chan Dang | 2014 | Mediators of Inflammation2014，，： | 1 |
| 11 | TP53 codon 72 polymorphism associated with prognosis in patients with advanced gastric cancer treated with paclitaxel and cisplatin显示文摘 | Jong Gwang Kim Sang Kyun Sohn Yee Soo Chae Hong Suk Song Ki-Young Kwon Young Rok Do Min Kyoung Kim Kyung Hee Lee Myung Soo Hyun Won Sik Lee Chang-Hak Sohn Joo Seop Jung Gab Chul Kim Ho Young Chung Wansik Yu | 2009 | Cancer Chemotherapy and Pharmacology2009，，2： | 1 |
| 12 | Prognostic index for vein tumor thrombosis in patients with hepatocellular carcinoma treat with radiation therapy显示文摘 | Jeong ll Yu Hee Chul Park | 2011 | Korean Med Sci2011，26，： | 1 |
| 13 | A hybrid semi-automatic method for liver segmentation based on level-set methods using multiple seed points 显示文摘 | Yang Xiaopeng Yu Hee Chul Choi Younggeun | 2014 | Computer Methods and Programs in Biomedicine2014，113，1： | 1 |
| 14 | Variable phenotype of Pierson syndrome显示文摘 | Hyun Jin Choi Beom Hee Lee Ju Hyung Kang Hyoen Joo Jeong Kyung Chul Moon Il Soo Ha Young Suk Yu Verena Matejas Martin Zenker Yong Choi Hae Il Cheong | 2008 | Pediatric Nephrology2008，，6： | 1 |
| 15 | Clinical impact of combined transarterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: An external validation study显示文摘 | Jeong Il Yu Jae Won Park Hee Chul Park Sang Min Yoon Do Hoon Lim Joon Hyeok Lee Han Chu Lee Seon Woo Kim Jong Hoon Kim | 2015 | Radiotherapy and Oncology2015，，： | 1 |
| 16 | Lymph Node Ratio as a Prognostic Factor in Patients With Stage III Rectal Cancer Treated With Total Mesorectal Excision Followed by Chemoradiotherapy显示文摘 | Young Seok Kim Jong Hoon Kim Sang Min Yoon Eun Kyung Choi Seung Do Ahn Sang-wook Lee Jin Cheon Kim Chang Sik Yu Hee Chul Kim Tae Won Kim Heung Moon Chang | 2009 | International Journal of Radiation Oncology Biology Physics2009，，3： | 1 |
| 17 | Lymph Node Ratio as a Prognostic Factor in Patients With Stage III Rectal Cancer Treated With Total Mesorectal Excision Followed by Chemoradiotherapy显示文摘 | Young Seok Kim Jong Hoon Kim Sang Min Yoon Eun Kyung Choi Seung Do Ahn Sang-wook Lee Jin Cheon Kim Chang Sik Yu Hee Chul Kim Tae Won Kim Heung Moon Chang | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，3： | 1 |
| 18 | Multicenter Analysis of Clinicopathologic Features of Intraductal Papillary Mucinous Tumor of the Pancreas: Is It Possible to Predict the Malignancy Before Surgery?显示文摘 | Jin-Young Jang MD Sun-Whe Kim MD FACS Young Joon Ahn MD Yoo-Seok Yoon MD Min Gew Choi MD Kuhn Uk Lee MD Joon Koo Han MD Woo Ho Kim MD Young Joo Lee MD Song Chul Kim MD Duck Jong Han MD Yong Il Kim MD Seong Ho Choi MD Baik Hwan Cho MD Hee Chul Yu MD Dong | 2005 | Annals of Surgical Oncology2005，，2： | 1 |
| 19 | Detection and characterization of liver metastases: 16--slice multidetector computed tomography versus superparamagnetic iron oxide-enhanced magnetic resonance imaging显示文摘 | Young Kon Kim Seog Wan Ko Seung Bae Hwang Chong Soo Kim Hee Chul Yu | 2006 | European Radiology2006，，6： | 1 |
| 20 | Predictive factors for local recurrence after endoscopic resection for early gastric cancer: long-term clinical outcome in a single-center experience显示文摘 | Jun Chul Park Sang Kil Lee Ju Hee Seo Yu Jin Kim Hyunsoo Chung Sung Kwan Shin Yong Chan Lee | 2010 | Surgical Endoscopy2010，，11： | 1 |
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