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| 1 | Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease显示文摘AIM: To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting. METHODS: For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire (ReQuest) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive(ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms. RESULTS: IBS-like symptoms were more prevalent in NERD than in ERD (18.3% vs 12.7%, P = 0.0015). Response rates after 4 and/or 8 wk of treatment were lower in patients with IBS-like symptoms than in patients without IBS-like symptoms in both ERD (Week 4: P < 0.0001, Week 8: P < 0.0339) and NERD (Week 8: P = 0.0088). At baseline, ReQuest 'lower abdominal com- plaints' symptom scores were highest in NERD patients with IBS-like symptoms. Additionally, these patients had the strongest symptom improvement after treatment compared with all other subgroups. CONCLUSION: IBS-like symptoms influence treatment outcome and symptom burden in GERD and should be considered in management. Proton pump inhibitors can improve IBS-like symptoms, particularly in NERD. | Hubert Mnnikes Robert C Heading Holger Schmitt Hubert Doerfler | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 2 | Evaluation of C-14 ages of organic fractions of paleosols from loess-paleosol sequences near Xian, China 显示文摘 | Head M J Zhou W J Zhou M F | 1989 | Radiocarbon1989，31，： | 1 |
| 3 | Wrist Ganglion Treatment: Systematic Review and Meta-Analysis显示文摘 | Head L Gencarelli JR Allen M | 2015 | J Hand Surg Am2015，40，3： | 1 |
| 4 | How can the web help build customer relationships?: An empirical study on etailing显示文摘 | Wang F Head M | 2007 | Information Management2007，44，2： | 1 |
| 5 | Dating nodes on molecular phylogenies:a critique of molecular biogeography显示文摘 | Heads M | 2005 | Cladistics2005，21，1： | 1 |
| 6 | Manipulating Perceived Social Presence through the Web Interface and Its Impact on Attitude Towards Online Shopping显示文摘 | Hassanein K Head M | 2007 | Internation- al Journal of Human-Computer Studies2007，65，8： | 1 |
| 7 | Determinants of cardiac fibrosis in experimental hypermineralocorticoid states显示文摘 | Young M Head G Funder JW | 1995 | Am J Physiol1995，269，： | 1 |
| 8 | Why is evidence on job strain and coronary heart disease mixed? An illustration of measurement challenges in the Whitehall II study 显示文摘 | Kivimaki M Head J Ferrie JE | 2006 | Psychosom Med2006，68，3： | 1 |
| 9 | Biodegradation, gas destruction and methane generation in deep subsurface petro- leum reservoirs: an overview显示文摘 | Larter S R Head I M Huang H | 2005 | Geological Society Lon- don Petroleum Geology Conference Series2005，6，： | 1 |
| 10 | Bioremediation: towards a credible technology 显示文摘 | Head I M | 1998 | Microbiology1998，144，： | 1 |
| 11 | Theoretical ecology for engineering biology 显示文摘 | CURBS T P HEAD L M GRAHAM D W | 2003 | Environmental Science & Technology2003，37，3： | 1 |
| 12 | Crude-oil biodegrada- tion via methanogenesis in subsurface petroleum reservoirs 显示文摘 | Jones D M Head I M Gray N D | 2008 | Nature2008，451，7175： | 1 |
| 13 | A single-chamber microbial fuel cell as a biosensor for wastewaters 显示文摘 | Di Lorenzo M Curtis TP Head IM | 2009 | Water Research2009，43，13： | 1 |
| 14 | Incidence and survival trends based on 1973- 2007 surveillance,epidemiology,and end results data显示文摘 | Ellington CL Goodman M Kono SA Adenoid cystic carcinoma of the head and neck | 2012 | Cancer2012，，： | 1 |
| 15 | ClpXP proteases positively regulate alginate overexpression and mucoid con- version in Pseudomonas aeruginosa 显示文摘 | QIU D EISINGER V M HEAD N E | 2008 | Microbiology2008，154，7： | 1 |
| 16 | Determinants of cardiac fibrosis in experimental hypermineralocorticoid states显示文摘 | YOUNG M HEAD G FUNDER J W | 1995 | AmJ Physio1995，269，41： | 1 |
| 17 | Design aesthetics leading to m -loyalty in mobile commerce 显示文摘 | CYR D HEAD M IVANOVO A | 2006 | Information and Management2006，43，8： | 1 |
| 18 | Effects of al-titude on the abundance and species richness of insect herbi-vores on bracken显示文摘 | LAWTON J H MACGARVIN M HEADS P A | 1987 | Journal of Animal Ecology1987，56，1： | 1 |
| 19 | Who is responsible for e-Learning success in higher education? A stakeholders' analysis 显示文摘 | Wagner N Hassanein K Head M | 2008 | Educational Technology and Society2008，11，3： | 1 |
| 20 | Why is evidence on job strain and coronary heart disease mixed? An illustration of measurement challenges in the Whitehall Ⅱ study 显示文摘 | Kivimaki M Head J Ferrie JE | 2006 | Psychosom Med2006，68，3： | 1 |
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