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您的检索式：作者名="He Renyang"
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| 1 | The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury显示文摘Sentrin-specific protease 3(SENP3), a member of the desumoylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways. However, its implication in myocardial ischemia reperfusion(MIR) injury is unclear. Here, we observed that SENP3 was expressed and upregulated in the mouse heart depending on reactive oxygen species(ROS) production in response to MIR injury. By utilizing si RNA-mediated cardiac specific gene silencing, SENP3 knockdown was demonstrated to significantly reduce MIR-induced infarct size and improve cardiac function. Mechanistic studies indicated that SENP3 silencing ameliorated myocardial apoptosis mainly via suppression of endoplasmic reticulum(ER) stress and mitochondrial-mediated apoptosis pathways. By contrast, adenovirusmediated cardiac SENP3 overexpression significantly exaggerated MIR injury. Further molecular analysis revealed that SENP3 promoted mitochondrial translocation of dynamin-related protein 1(Drp1) in reperfused myocardium. In addition, mitochondrial division inhibitor-1(Mdivi-1), a pharmacological inhibitor of Drp1, significantly attenuated the exaggerated mitochondrial abnormality and cardiac injury by SENP3 overexpression after MIR injury. Taken together, we provide the first direct evidence that SENP3 upregulation pivotally contributes to MIR injury in a Drp1-dependent manner, and suggest that SENP3 suppression may hold therapeutic promise for constraining MIR injury. | Lingchen Gao Yichao Zhao Jie He Yang Yan Longwei Xu Nan Lin Qingqi Ji Renyang Tong Yanan Fu Yu Gao Yuanyuan Su Ancai Yuan Ben He Jun Pu | 2018 | Journal of Genetics and Genomics2018，45，3： | 5 |
| 2 | Numerical simulation of predicting and reducing solid particle erosion of solid-liquid two-phase flow in a choke显示文摘Chokes are one of the most important components of downhole flow-control equipment.The particle erosion mathematical model,which considers particle-particle interaction,was established and used to simulate solid particle movement as well as particle erosion characteristics of the solid-liquid two-phase flow in a choke.The corresponding erosion reduction approach by setting ribs on the inner wall of the choke was advanced.This mathematical model includes three parts:the flow field simulation of the continuous carrier fluid by an Eulerian approach,the particle interaction simulation using the discrete particle hard sphere model by a Lagrangian approach and calculation of erosion rate using semi-empirical correlations.The results show that particles accumulated in a narrow region from inlet to outlet of the choke and the dominating factor affecting particle motion is the fluid drag force.As a result,the optimization of rib geometrical parameters indicates that good anti-erosion performance can be achieved by four ribs,each of them with a height(H) of 3 mm and a width(B) of 5 mm equaling the interval between ribs(L). | Li Guomei Wang Yueshe He Renyang Cao Xuewen Lin Changzhi Meng Tao | 2009 | Petroleum Science2009，6，1： | 3 |
| 3 | 显示文摘 | Zhang S W He Renyang Wang Deguo | 2001 | Journal of Materials Science2001，，36： | 1 |
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