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| 1 | Nonalcoholic fatty liver disease:A comprehensive review of a growing epidemic显示文摘Nonalcoholic fatty liver disease(NAFLD)is quickly becoming one of the most prominent causes of liver disease worldwide.The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it.Current efforts to elucidate the mechanism and causes of the disease have answered some questions,but much remains unknown about NAFLD.The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease,as well as the current and future diagnostic,preventative,and therapeutic options available to clinicians for the management of NAFLD. | Kareem Hassan Varun Bhalla Mohammed Ezz El Regal H Hesham A-Kader | 2014 | World Journal of Gastroenterology2014，20，34： | 36 |
| 2 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 3 | Effect of mucin production on survival in colorectal cancer:A case-control study显示文摘AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor stage.METHODS: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC. OS and TTP were compared among 4 groups divided according to mucin content: group A (50%-75% mucin), group B (75%-100% mucin), group C or controls (< 50% mucin). Group D consisted of all patients with tumors having < 75% mucin (controls and groups A together).RESULTS: Median survival in MCRC and NMCRC groups was 46.2 and 112.9 mo, respectively (P = 0.26). OS in groups A and B was 70.1 and 32.8 mo (P = 0.46), and in groups B and D was 32.8 and 70.1 mo, respectively (P = 0.143). TTP in MCRC and NMCRC was 50.17 and 44.77 mo, respectively (P = 0.795). TTP in groups A, B, and D was 70.1, 24.8, and 65.5 mo, respectively. Twenty-eight percent of patients with MCRC had poorly differentiated adenocarcinoma versus 8.6% in NMCRC patients (P = 0.028).CONCLUSION: MCRC is associated with a non-significant decrease in median survival and TTP, particularlywhen mucin content is > 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed. | Mirna H Farhat Kassem A Barada Ayman N Tawil Doha M Itani Hassan A Hatoum Ali I Shamseddine | 2008 | World Journal of Gastroenterology2008，14，45： | 6 |
| 4 | Liver stiffness as a predictor of hepatocellular carcinoma behavior in patients with hepatitis C related liver cirrhosis显示文摘Background: Risk strati cation and prognostication of hepatocellular carcinoma (HCC) help to improve patient outcome. Herein we investigated the role of liver stiffness measurement (LSM) in the prediction of HCC behavior. Methods: Totally 121 na ve patients with HCC were included. HCC radiological evaluation and staging were done. LSM was measured using virtual touch quanti cation. Patients were divided into early to intermediate HCC (BCLC-0, A and B) and late HCC (BCLCC and D). HCC was treated according to the BCLC stage. HCC recurrence-free interval was estimated. Results: The mean LSM inside the tumor was signi cantly lower than the peri-tumoral area and the cirrhotic non-cancerous liver parts (P<0.001). In late HCCs stage, the mean LSM inside the tumor and in the peri-tumoral tissue was lower than the corresponding values in the early to intermediate HCCs stage (P<0.001). LSM inside the tumor and in the peri-tumoral tissue negatively correlated with serum AFP, tumor vascular invasion, and stage (P<0.05). The recurrence-free interval was directly correlated to LSM inside the tumor and inversely to LSM in cirrhotic non tumorous liver part. Kaplan-Meier analysis showed that the recurrence-free interval was signi cantly longer in patients with LSM inside the tumor of ≥1.25m/s compared to those with LSM inside the tumor of<1.25m/s. Conclusions: LSM can serve as a potential non-invasive predictor for HCC clinical behavior and the recurrence-free interval following loco-regional treatments. | Sameh A Lashen Mohamed M Elshafei Fahmy H Hablass Eman A Alsayed Asmaa A Hassan | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 4 |
| 5 | Immunization against Egyptian Schistosoma mansoni infection by multivalent DNA vaccine显示文摘由几抗原组成的多价的疫苗的发展是对不同寄生虫紧张和寄生虫生命周期阶段创造宽广范围的保护的一条新奇途径。我们以前证实了血吸虫 Sm21.7 和 Sm Fimbrin (SmFim ) 蛋白质能在老鼠导致保护。因此,这研究试图构造多价的 DNA 疫苗的 Sm21.7-SmFim/pBudCE4.1 并且评估它的有免疫力的功效。二血吸虫 mansoni 基因, Sm21.7 和 SmFim 的开的读物框架,被插入到为独立人士设计的真核细胞的表示原生质标志 pBudCE4.1 在哺乳动物的房间的二基因的表示。评估在里面在老鼠的多价的 Sm21.7-SmFim/pBudCE4.1 DNA 疫苗和它的免疫学的效果的 vitro 表示, recombinant 原生质标志 Sm21.7-SmFim/pBudCE4.1 习惯于 mRNA 的 transfect 293T 房间,和表示,蛋白质用反向的抄写聚合酶链反应和蛋白质印迹分析被检验。然后 Sm21.7-SmFim/pBudCE4.1 到的能力免于 S。mansoni 挑战感染在老鼠的种痘以后根据蠕虫负担和鸡蛋减小率被分析。种牛痘的老鼠出现了保护(56%) 的重要水平,和在数字和尺寸的减少,和在细胞的侧面的变化, granulomas。分别地,在肝和肠的鸡蛋减小是 41.53% 和 55.63% 相对仅仅收到了空向量的老鼠同样坚定。除了在蠕虫生存能力的减小,蠕虫肥沃和鸡蛋孵化能力被观察在使免疫的组跟随挑战感染。结果证明 Sm21.7-SmFim/pBudCE4.1 能表示 Sm2 1.7 和 SmFim mRNA 和蛋白质。连接酶的免疫吸着剂试金和蛋白质印迹分析显示使免疫的老鼠对 Sm21.7-SmFim/pBudCE4.1 产生了特定的免疫球蛋白 G。这些结果与多价的 S 建议那种痘。mansoni DNA 疫苗(SmFim-Sm21.7/pBudCE4.1 ) 不仅在蠕虫和卵负担导致重要减小,而且显著地减少卵 granulomas 的尺寸。在摘要,多价的疫苗与保护的重要水平刺激了特定的免疫并且反病理学的效果。 | Mahmoud H Romeih Hanem M Hassan Tarek S Abou Shousha Mohamed A Saber | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 3 |
| 6 | Bowel perforation due to break and distal passage of the safety ring of an adjustable intra-gastric balloon: A potentially life threatening situation显示文摘A 45-year-old man of Middle Eastern origin, morbid obese, with a body mass index of 39 had an intragastric balloon, filled with 500 mL of saline/methylene blue and intended as definite therapy, inserted some8 wk previously. He was admitted to the emergency department with abdominal cramps. An ultrasound of the abdomen was performed in ER which confirmed the balloon to be in place without any abnormality.He was discharged home on symptomatic medication.Patient remains symptomatic therefore he reported back to ER 2 d later. Computed tomography scan was performed this time for further evaluation which revealed a metallic ring present in the small bowel while the intra-gastric balloon was in its proper position.There was no clinical or radiological sign of intestinal obstruction. Patient was hospitalized for observation and conservative management. The following night,patient experienced sudden and severe abdominal pain, therefore an X-ray of the abdomen in erect position was done, which showed free air under the right dome of diaphragm. Patient was transferred to O.R for emergency laparotomy. There were two small perforations identified at the site of the metallic ring entrapment. The ring was removed and the perforations were repaired. Due to increasing prevalence of obesity and advances in modalities for its management,physicians should be aware of treatment options, their benefits, complications and clinical presentation of the known complications. Physicians need to be updated to approach these complications within time, to avoid lifethreatening situations caused by these appliances. | Ali M Al-Zubaidi Hassan U Alghamdi Abdu H Alzobydi Irshad A Dhiloon Laeeque A Qureshi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 3 |
| 7 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 8 | The biology and demographic parameters of Aedes albopictus in northern peninsular Malaysia显示文摘Objective:To generate life table characteristics for the dengue vector Aedes albopictus(A. albopictus) under uncontrolled conditions,incorporating both the aquatic and the adult stages. Methods:Ten females derived from wild pupae were allowed to fully blood-feed on restrained mice.774 eggs were hatched in seasoned water.F1 larvae were followed for development until their F2 counterparts emerged as adults.Some population parameters were monitored(Fl) or estimated(F2).Results:A.albopictus exhibited increased fecundity and egg hatch success. Immature development was quick.Immature survival was high,with lowest rate in the pupal stage.Adult emergence was about 81%and sex ratio was close to 1:1.Generational mortality(K) was about 28%.A high proportion of females completed a reproductive cycle and the obtained parity rate was predicted to lead to higher fecundity in the next generation.Conclusios:It can be concluded that natural A.albopictus populations in Penang seem largely determined by quick development in combination with low immature loss and increased oviposition. | H Nur Aida Hamady Dieng Abu Hassan Ahmad Tomomitsu Satho AT Nurita MR Che Salmah Fumio Miake B Norasmah | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 2 |
| 9 | Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: Risk and prognosis prediction显示文摘 | Manal M. Hassan Ahmed Kaseb Carol J. Etzel Hashem El‐Serag Margaret R. Spitz Ping Chang Katherine S. Hale Mei Liu Asif Rashid Mohamed Shama James L. Abbruzzese Evelyne M. Loyer Harmeet Kaur Hesham M. Hassabo Jean‐Nicolas Vauthey Curtis J. Wray Basmah S. H | 2013 | Mol Carcinog2013，，1： | 2 |
| 10 | Frequency of diabetic retinopathy and associated risk factors in Khartoum,Sudan:population based study显示文摘AIM: To assess the frequency and associated risk factors of diabetic retinopathy among Sudanese individuals with diabetes attending Makka Eye complex in Khartoum, Sudan. METHODS: The cross sectional hospital based study recruited 316 individuals with diabetes from Makkah Eye Complex Retina Clinic. Standard questionnaire was used to collect demographic data, medical history and life style characteristics. Blood samples were taken to measure Hb A1 c and lipid profile. Fundus and slit lamp examination were performed for screening of diabetic retinopathy.RESULTS: Among 316 participants, 187(59.2%) were males and 129(40.8%) were females. The mean age of participants was 58.7±10.5y. The overall frequency of retinopathy was 261(82.6%). The percentages of the total participants with proliferative diabetic retinopathy(PDR) were 126(39.9%) and non-proliferative diabetic retinopathy(NPDR) were 135(42.7%). Importantly, duration of diabetes mellitus(DM)(72.2% of more than 10y), being on oral hypoglycaemic drugs(versus insulin), and hypertension were all significant risk factors for diabetic retinopathy(P=0.00, 0.01 and 0.00 respectively). Complications ofdiabetes like diabetic foot(17.7%), history of amputation(6.7%) and clinically significant macular edema(CSME)(47.4%) of the eyes were all significant risk factors(P<0.05). Logistic regression analysis showed that duration of diabetes, hypertension and CSME were found to be absolute risk factors(P=0.007, 0.003 and 0.000 respectively). Duration of DM of more than 10 y have more than double risk(OR=2.8), while having hypertension triples the risk of retinopathy(OR=3.1).CONCLUSION: High rates of diabetic retinopathy are noted among individuals with diabetes attending Makkah Eye hospital in capital Khartoum. Urgent strategies are needed to monitor and treat hypertension and optimize diabetes control in individuals with diabetes. More investment in diabetes services is urgently needed. | Einas S Elwali Ahmed O Almobarak Mona A Hassan Amir A Mahmooud Heitham Awadalla Mohamed H Ahmed | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 2 |
| 11 | Nonlinear output feedback tracking using high-gain observer and variable structure control 显示文摘 | Seungrohk O H Hassan K K | 1997 | Automatica1997，33，10： | 2 |
| 12 | Pioglitazone reduces blood pressure in non-dipping diabetic patients显示文摘 | Negro R Dazzi D Hassan H | 2004 | Minerva Endocrinol2004，29，1： | 1 |
| 13 | Expression and func- tional characterization of bluetongue virus VP5 protein: role in cellular permeabilization显示文摘 | Hassan S H Wirblich C Forzan M | 2001 | Virol2001，75，18： | 1 |
| 14 | Effects of levosimendan on myocardial contractility and Ca^2+ transients in aequorin-loaded right-ventricular muscles and indo-1-loaded single ventricular cardiomyocytes of the rabbit显示文摘 | Sato S Hassan Talukoler MA Sugawara H | 1998 | J Mol Cell Cardiol1998，30，8： | 1 |
| 15 | Therapeutic considerations in the management of agitated or delirious critically ill patients显示文摘 | HASSAN E FONTAINE D K NEARMAN H S | 1998 | Pharmacotherapy1998，18，： | 1 |
| 16 | A robust LMI- based pitch controller for large wind turbines 显示文摘 | HASSAN H M EISHAFEI A L FARAG W A et d | 2012 | Renewable Energy2012，44，1： | 1 |
| 17 | Technical challenges of coronary CT angiography: today and tomorrow显示文摘 | Hassan A Nazir SA Alkadhi H | 2011 | Eur J Radiol2011，79，2： | 1 |
| 18 | Transcriptional and functional analysis of oxalyl-coenzyme A (CoA) deearboxylase and formyl-coA transferase genes from Lae- tobacillus acidophilus显示文摘 | zcarate-Peril M A Bruno-Bdrcena J M Hassan H M | 2006 | Appl Environ Microbiol2006，72，3： | 1 |
| 19 | Nano-struetured carbon as electrode material in microbial fuel eells:A comprehensive review 显示文摘 | Ghasemi M Daud W R W Hassan S H A | 2013 | Journal of Alloys and Compeunds2013，580，15： | 1 |
| 20 | A novel approach to enhance the activity of H-form zeolite catalyst for production of hydroxymethylfurfural from cellulose显示文摘 | ABOU-YOUSEF H HASSAN E B | 2014 | Journal of Industrial and Engineering Chemistry2014，20，4： | 1 |
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