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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Regulation of cancer cell metabo- lism显示文摘 | Cairns RA Harris IS Mak TW | 2011 | Nat Rev Cancer2011，11，2： | 1 |
| 3 | Regulation of cancer cell metabolism 显示文摘 | Cairns RA IS Harris TW Mak | 2011 | Nat Rev Cancer2011，11，2： | 1 |
| 4 | WormBase: A multi- species resource for nematode biology and genomics 显示文摘 | Harris TW Chen N Cunningham F | 2004 | Nucleic Acids Res2004，32，22： | 1 |
| 5 | The outpatient vagingal hysterectomy显示文摘 | Powers TW Goodno JA Harris VD | 1993 | Am J Obstet Gynecol1993，168，61： | 1 |
| 6 | FOXO3a is activated in response to hypoxic stress and inhibits HIF1 - induced ap- optosis via regulation of CITED2 显示文摘 | Bakker WJ Harris IS Mak TW | 2007 | Mol Cell2007，28，6： | 1 |
| 7 | The outpatient vaginal hysterectomy 显示文摘 | Powers TW Goodno JA Harris VD | 1993 | Am J Obstet Gynecol1993，168，12： | 1 |
| 8 | The outpatient vaginal hysterectomy 显示文摘 | Powers TW Goodno JA Jr Harris VD | 1993 | Am J Obstet Gynecol1993，168，： | 1 |
| 9 | Regulation of cancer cell metabolism显示文摘 | Cairns RA Harris IS Mak TW | 2011 | Nat Rev Cancer2011，11，2： | 1 |
| 10 | Regulation of cancer cell metabolism 显示文摘 | Cairns RA Harris IS Mak TW | 2011 | Nat RevCancer2011，11，2： | 1 |
| 11 | The diagnostic and therapeutic utility of thoracoscopy: a revuew 显示文摘 | Harris R J Kavuru MS Rice TW | 1995 | Chest1995，108，： | 1 |
| 12 | Regulation of cancer cell metabolism显示文摘 | Cairns RA Harris IS Mak TW | | 0，，02： | 1 |
| 13 | The outpatient vaginal hysterectomy显示文摘 | Powers TW Goodno JA Jr Harris VD | 2006 | Am J Obstet Gynecol2006，168，61： | 1 |
| 14 | Regulation of cancer cell metabolism显示文摘 | Cairns RA Harris IS Mak TW | 2011 | Nat Rev Cancer2011，11，2： | 1 |
| 15 | Regulation of cancer cell metabolism 显示文摘 | Cairns RA Harris IS Mak TW | 2011 | Nat Rev Cancer2011，11，2： | 1 |
| 16 | The outpatient vaginal hysterectomy显示文摘 | Powers TW Goodno JA Harris VD | 1993 | Am J Obster Gynecol1993，168，： | 1 |
| 17 | The diagnostic and therapeutic utility of thoracoscopy:a review显示文摘 | Harris RJ Kavuru MS Rice TW | 1995 | Chest1995，108，7： | 1 |
| 18 | Hyperbaric oxygen therapy of cerebral isehemia显示文摘 | Harry TW Michel TT | 2005 | Cerebrovasc Dic2005，20，： | 1 |
| 19 | Regulation of cancer cell metabo- lism显示文摘 | Caims RA Harris IS Mak TW | 2011 | Nat Rev Cancer2011，11，2： | 1 |
| 20 | The outpatient vaginal hysterectomy显示文摘 | Powers TW Goodno JA Harris VD | 1993 | Am J Obstet Gynecol1993，168，10： | 1 |
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