|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy显示文摘Conventional immunohistochemistry(IHC)is a widely used diagnostic technique in tissue pathology.However,this technique is associated with a number of limitations,including high inter-observer variability and the capacity to label only one marker per tissue section.This review details various highly multiplexed techniques that have emerged to circumvent these constraints,allowing simultaneous detection of multiple markers on a single tissue section and the comprehensive study of cell composition,cellular functional and cell-cell interactions.Among these techniques,multiplex Immunohistochemistry/Immunofluorescence(mIHC/IF)has emerged to be particularly promising.mIHC/IF provides high-throughput multiplex staining and standardized quantitative analysis for highly reproducible,efficient and cost-effective tissue studies.This technique has immediate potential for translational research and clinical practice,particularly in the era of cancer immunotherapy. | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2020 | Cancer Communications2020，40，4： | 11 |
| 2 | 肿瘤免疫治疗时代的多重免疫组织化学/免疫荧光技术显示文摘常规免疫组织化学(immunohistochemistry,IHC)是组织病理学中广泛应用的诊断技术。但该技术存在诸多局限性,包括观察者间的变异性高,每张组织切片仅能标记一个标志物。本文详细描述了各种多重检测技术,这些技术克服了上述局限性,可在单张切片上同时检测多个标志物,可对细胞组成、细胞功能和细胞间相互作用进行整合研究。在这些技术中,多重免疫组织化学/免疫荧光(multiplex immunohistochemistry/immunofluorescence,mIHC/IF)已成为最具应用前景的技术。mIHC/IF为开展高重复性、高效、高性价比的组织研究提供了高通量多重染色技术和标准化的定量分析。该技术在转化研究和临床实践中,尤其是肿瘤免疫治疗中极具应用价值。 | Wei Chang Colin Tan Sanjna Nilesh Nerurkar Hai Yun Cai Harry Ho Man Ng Duoduo Wu Yu Ting Felicia Wee Jeffrey Chun Tatt Lim Joe Yeong Tony Kiat Hon Lim | 2021 | 癌症2021，40，9： | 2 |
| 3 | On Product-Cordial Index Sets and Friendly Index Sets of 2-Regular Graphs and Generalized Wheels显示文摘A vertex labeling f : V → Z2 of a simple graph G = (V, E) induces two edge labelings f+ , f*: E → Z2 defined by f+ (uv) = f(u)+f(v) and f*(uv) = f(u)f(v). For each i∈Z2 , let vf(i) = |{v ∈ V : f(v) = i}|, e+f(i) = |{e ∈ E : f+(e) = i}| and e*f(i)=|{e∈E:f*(e)=i}|. We call f friendly if |vf(0)-vf(1)|≤ 1. The friendly index set and the product-cordial index set of G are defined as the sets{|e+f(0)-e+f(1)|:f is friendly} and {|e*f(0)-e*f(1)| : f is friendly}. In this paper we study and determine the connection between the friendly index sets and product-cordial index sets of 2-regular graphs and generalized wheel graphs. | Harris KWONG Sin Min LEE Ho Kuen NG | 2012 | Acta Mathematica Sinica,English Series2012，28，4： | 2 |
| 4 | MRI measurement of blood-brain barrier permeability following spontaneous reperfusion in the microsphere model of ischemia显示文摘 | Harris NG Gauden V Fraser PA | 2002 | Magn Reson Imaging2002，20，3： | 1 |
| 5 | MRI measurement of blood-brain barrier permeability following spontaneous reperfusion in the starch microsphere model of ischemia显示文摘 | Harris NG Gauden V Fraser PA | 2002 | Magn Reson Imaging2002，20，： | 1 |
| 6 | CO2 cerebrovas- cular reactivity as a function of perfusion pressure-a modelling study显示文摘 | Czosnyka M Harris NG Pickand JD | 1993 | Acta Neurochir1993，121，34： | 1 |
| 7 | Traumatic brain injury induced neuroprotection of retinal ganglion cells to optic nerve crush显示文摘 | Ben Simon GJ Hovda DA Harris NG | 2006 | J Neurotrauma2006，23，7： | 1 |
| 8 | The relationship between the apparent diffusion coefficient measured by magnetic resonance imaging,anoxic depolarization,and glutamate efflux during experimental ischemia显示文摘 | Harris NG Zikha E Houseman J | 2000 | J Cereb Blood Flow Metab2000，20，2： | 1 |
| 9 | Tourism,Economic Welfare and Efficient Pricing显示文摘 | Harry C R Yew-Kwang Ng | | 0，，04： | 1 |
| 10 | Hitting a moving target: Basic mechanisms of recovery from acquired developmental brain injury 显示文摘 | Giza CC Kolb B Harris NG | 2009 | Dev Neurorehabil2009，12，5： | 1 |
| 11 | MgOHCl thermal decomposition kinetics显示文摘 | S. Kashani-Nejad K. -W. Ng R. Harris | 2005 | Metallurgical and Materials Transactions B2005，，1： | 1 |
| 12 | Ipsilateral floating second etatarsal and ankle fracture dislocation: complications and outcome of a rare type of injury 显示文摘 | Lasanianos NG Kanakaris NK Harris N | 2010 | Orthopedies2010，33，5： | 1 |
| 13 | Preparation of MgOHCl by controlled dehydration of MgCl2·6H2O显示文摘 | S. Kashani-Nejad K. W. Ng R. Harris | 2004 | Metallurgical and Materials Transactions B2004，，2： | 1 |
| 14 | Properties of MgOHCl显示文摘 | S. Kashani-Nejad K. W. Ng R. Harris | 2004 | Metallurgical and Materials Transactions B2004，，2： | 1 |
| 15 | Pericontusion axon sprou- ting is spatially and temporally consistent with a growth-permissive environment after traumatic brain injury显示文摘 | Harris NG Mironova YA Hovda DA | 2010 | J Neuropathol Exp Neurol2010，69，2： | 1 |
| 16 | Strategic Lessons of Value Migration in IT Industry 显示文摘 | Andy Ng P T Lu D W Li C K Harry Chan H Y | 2005 | Technovation2005，，25： | 1 |
| 17 | Plasmas as antennas: Theory, experiment and applications 显示文摘 | G G Borg J H Harris N M Martin D Thorncraft R Milliken D G Miljak B Kwan T Ng and J Kircher | 2000 | Physics of Plasmas2000，7，5： | 1 |
| 18 | Traumatic brain injury results in disparate regions of chondroitin sulfate pro- teoglycan expression that are temporally limited显示文摘 | Harris NG Carmichael ST Hovda DA | 2009 | J Nem~)sci Res2009，87，13： | 1 |
| 19 | Arterial oxygen saturation during upper gastrointestinal endoscopy:influence of sedation and operator experience显示文摘 | Lavies NG Creasy T Harris K | 1988 | Am J Gastroenterol1988，83，： | 1 |
| 20 | Near patient blood ketone measurements and their utility in predicting diabetic ketoacidosis显示文摘 | Harris S Ng R Syed H | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员