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| 1 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 2 | 聚乙二醇干扰素α-2b单药或聚乙二醇干扰素α-2b联合拉米夫定治疗HBeAg阳性慢性乙型肝炎的多中心、随机、双盲、对照试验显示文摘 与干扰素非应答者相比,应答的慢性乙型肝炎(乙肝)患者发生肝硬化、肝衰竭及肝细胞癌的可能性明显下降[1,2].然而,大部分慢性乙肝患者不能获得应答.在已经获得批准治疗慢性乙肝的药物中,最常用的是干扰素和核苷类似物,如拉米夫定或阿德福韦.…… | Harry LA Janssen | 2005 | 传染病信息2005，18，z1： | 4 |
| 3 | Telaprevir/boceprevir era: From bench to bed and back显示文摘Hepatitis C virus (HCV) infects approximately 200 million people worldwide. Interferon-based therapies have dominated over the past two decades. However, the overall response rates remain suboptimal. Thanks to the tremendous effort from both academia and industry, two serine protease inhibitors telaprevir and boceprevir for treating chronic hepatitis C have finally reached the clinic. Although these compounds are only approved for combination use with interferon and ribavirin in genotype 1 HCV infected chronic patients, the management of HCV patients however is now evolving incredibly. Here, we overviewed a series of landmark studies, regarding the clinical development of telaprevir and boceprevir. We discussed the mechanism-of-action of telaprevir/boceprevir and their potential application in HCV-positive liver transplantation patients. We further emphasized some emerging concerns with perspective of further development in this field. | Maikel P Peppelenbosch Harry LA Janssen Robert J de Knegt | 2012 | World Journal of Gastroenterology2012，18，43： | 3 |
| 4 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet . 2005 (9454)2005，，： | 2 |
| 5 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | 2005 (9454)2005，，9454： | 1 |
| 6 | Changes in heart rate var- la billty under propofol anesthesia a possible explanation for propo- fol induced brady earidia 显示文摘 | Deutsehman CS Harris AP Fleisher LA | 1994 | Aresth Araly1994，79，2： | 1 |
| 7 | Relapse of Chronic Hepatitis B After Discontinuation of Nucleos (t) ide Analogs: Is the Glass Half Full or Half Empty? 显示文摘 | Jurrien GP Reijnders MD Harry LA | 2013 | Hepatology2013，58，6： | 1 |
| 8 | Irritable bowel syndrome and chron- ic constipation: emerging drugs, devices, and surgical treatments 显示文摘 | Harris LA Hansel S DiBaise J | 2006 | Curr Gastroenterol Rep2006，8，4： | 1 |
| 9 | Occupational exposures in emergency medical service providers and knowledgeof and compliance with universal precautions 显示文摘 | Harris SA Nicolai LA | 2010 | Am J Infect Control2010，38，： | 1 |
| 10 | Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat 显示文摘 | Brown LA Ping XD Harris FL | 2007 | Am J Physiol Lung Cell Mol Physiol2007，292，4： | 1 |
| 11 | Neuroleptic withdrawal in schizophrenic patients显示文摘 | Gilbert PL Harris J Mcdams LA | 1995 | Arch Gen Psychiatry1995，52，3： | 1 |
| 12 | Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High- Value Care From the American College of Physicians and Centers for Disease Control and Prevention显示文摘 | Harris AM Hicks LA Qaseem A | 2016 | Annals of lnlernal Medicine2016，146，6： | 1 |
| 13 | Changes in heart rate variabilty under propofol anesthesia:a possible explanation for propofol induced bradycardia 显示文摘 | Harris AP Fleisher LA | 1994 | Anesth Analg1994，79，： | 1 |
| 14 | Chronic ethanol ingestion and the risk of acute lung injury:a role for glutathione availability?显示文摘 | Brown LA Harris FL Ping XD | 2003 | Alcohol2003，33，： | 1 |
| 15 | bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitars显示文摘 | O'Beilly LA Harris AW Strasser A | 1997 | Int Immunol1997，9，9： | 1 |
| 16 | Chronic ethanol ingestion and the risk of acute lung injury:a role for glutathione availability?显示文摘 | Brown LA Harris FL Ping XD | 2004 | Alcohol2004，33，3： | 1 |
| 17 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet2005，，9454： | 1 |
| 18 | Bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8 Tcell progenitors显示文摘 | Harris AW StrasserA | 1997 | Int Immunol1997，9，9： | 1 |
| 19 | A web - based survey on mephedrone显示文摘 | Carhart - Harris RL King LA Nutt DJ | 2011 | Drug Alcohol Depend2011，118，1： | 1 |
| 20 | The molecular biolo-gy of human iron metabolism显示文摘 | Winter WE Bazydlo LA Harris NS | 2014 | Lab Med2014，45，2： | 1 |
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