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| 1 | Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing显示文摘The occurrence of a large number of diverse arsenic species in the environment and in biological systems makes it important to compare their relative toxicity. The toxicity of arsenic species has been examined in various cell lines using different assays, making comparison difficult. We report real-time cell sensing of two human cell lines to examine the cytotoxicity of fourteen arsenic species: arsenite(As~Ⅲ), monomethylarsonous acid(MMA~Ⅲ) originating from the oxide and iodide forms, dimethylarsinous acid(DMA~Ⅲ), dimethylarsinic glutathione(DMAG~Ⅲ), phenylarsine oxide(PAO~Ⅲ), arsenate(AsV), monomethylarsonic acid(MMA~Ⅴ), dimethylarsinic acid(DMA~Ⅴ),monomethyltrithioarsonate(MMTTA~Ⅴ), dimethylmonothioarsinate(DMMTA~Ⅴ),dimethyldithioarsinate(DMDTA~Ⅴ), 3-nitro-4-hydroxyphenylarsonic acid(Roxarsone, Rox),and 4-aminobenzenearsenic acid(p-arsanilic acid, p-ASA). Cellular responses were measured in real time for 72 hr in human lung(A549) and bladder(T24) cells. IC50 values for the arsenicals were determined continuously over the exposure time, giving rise to IC50 histograms and unique cell response profiles. Arsenic accumulation and speciation were analyzed using inductively coupled plasma-mass spectrometry(ICP-MS). On the basis of the 24-hr IC50 values, the relative cytotoxicity of the tested arsenicals was in the following decreasing order: PAO~Ⅲ? MMA~Ⅲ≥ DMA~Ⅲ≥ DMAG~Ⅲ≈ DMMTA~Ⅴ≥ As~Ⅲ? MMTTA~Ⅴ> AsV> DMDTA~Ⅴ>DMA~Ⅴ> MMA~Ⅴ≥ Rox ≥ p-ASA. Stepwise shapes of cell response profiles for DMA~Ⅲ, DMAG~Ⅲ,and DMMTA~Ⅴcoincided with the conversion of these arsenicals to the less toxic pentavalent DMA~Ⅴ. Dynamic monitoring of real-time cellular responses to fourteen arsenicals provided useful information for comparison of their relative cytotoxicity. | Birget Moe Hanyong Peng Xiufen Lu Baowei Chen Lydia W.L.Chen Stephan Gabos Xing-Fang Li X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 19 |
| 2 | Methylated and thiolated arsenic species for environmental and health research——A review on synthesis and characterization显示文摘Hundreds of millions of people around the world are exposed to elevated concentrations of inorganic and organic arsenic compounds, increasing the risk of a wide range of health effects. Studies of the environmental fate and human health effects of arsenic require authentic arsenic compounds. We summarize here the synthesis and characterization of more than a dozen methylated and thiolated arsenic compounds that are not commercially available. We discuss the methods of synthesis for the following14 trivalent(Ⅲ) and pentavalent() arsenic compounds: monomethylarsonous acid(MMA~Ⅲ), dicysteinylmethyldithioarsenite(MMA~Ⅲ(Cys)_2), monomethylarsonic acid(MMA~Ⅴ),monomethylmonothioarsonic acid(MMMTAⅤ) or monothio-MMA~Ⅴ, monomethyldithioarsonic acid(MMDTA~Ⅴ) or dithio-MMA~Ⅴ, monomethyltrithioarsonate(MMTTA~Ⅴ) or trithio-MMA~Ⅴ,dimethylarsinous acid(DMA~Ⅲ), dimethylarsino-glutathione(DMA~Ⅲ(SG)), dimethylarsinic acid(DMA~Ⅴ), dimethylmonothioarsinic acid(DMMTA~Ⅴ) or monothio-DMAⅤ, dimethyldithioarsinic acid(DMDTA~Ⅴ) or dithio-DMA~Ⅴ, trimethylarsine oxide(TMAO~Ⅴ), arsenobetaine(AsB), and an arsenicin-A model compound. We have reviewed and compared the available methods,synthesized the arsenic compounds in our laboratories, and provided characterization information. On the basis of reaction yield, ease of synthesis and purification of product, safety considerations, and our experience, we recommend a method for the synthesis of each of these arsenic compounds. | William R.Cullen Qingqing Liu Xiufen Lu Anthony McKnight-Whitford Hanyong Peng Aleksandra Popowich Xiaowen Yan Qi Zhang Michael Fricke Hongsui Sun X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 12 |
| 3 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 4 | Consumption of rice and fish in an electronic waste recycling area contributes significantly to total daily intake of mercury显示文摘Mercury is a global pollutant due to its widespread use,emission,and long-range transport(Blum,2013;Pacyna et al.,2010).It is considered a priority pollutant due to its neurological toxicity,persistence,and bioaccumulation(Pacyna et al.,2010;Sharma et al.,2015).Mercury pollution can occur when products that contain mercury are improperly disposed of and mercury is released into the air,water,and soil(Zhang and Wong,2007).An estimated 22%of the annual world usage of mercury is in electrical equipment such as batteries,thermometers,and discharge lamps,and electronic devices such as monitors | Hanyong Peng Michael S.Reid X.Chris Le | 2015 | Journal of Environmental Sciences2015，27，12： | 5 |
| 5 | Separation/preconcentration of trace amounts of Cr, Cu and Pb in environmental samples by magnetic solid-phase extraction with Bismuthiol-II-immobilized magnetic nanoparticles and their determination by ICP-OES显示文摘 | Jibrin Sabo Suleiman Bin Hu Hanyong Peng Chaozhang Huang | 2008 | Talanta2008，，5： | 1 |
| 6 | Dithizone modified magnetic nanoparticles for fast and selective solid phase extraction of trace elements in environmental and bio- logical samples prior to their determination by ICP-OES 显示文摘 | Cheng Guihong He Man Peng Hanyong | 2012 | Talanta2012，88，： | 1 |
| 7 | Fast and se- lective magnetic solid phase extraction of trace Cd, Mn and Pb in environmenta 1 and biological samples and their deter- mina tion by ICP-MS 显示文摘 | Zhang Nan Peng Hanyong Wang Shen | 2011 | Microchim Acta2011，175，： | 1 |
| 8 | Separation/preconcentration of trace amounts of Cr, Cu and Pb in environmental samples by magnetic solid-phase extraction with Bismuthiol-II-immobilized magnetic nanoparticles and their determination by ICP-OES显示文摘 | Jibrin Sabo Suleiman Bin Hu Hanyong Peng Chaozhang Huang | 2008 | Talanta2008，，5： | 1 |
| 9 | Simultaneous removal of arsenic and antimony from mining wastewater显示文摘Arsenic(As)and antimony(Sb)rank 1 st and 244 th,respectively,on the 2019 Substance Priority List of the Agency for Toxic Substances and Disease Registry(ATSDR,2019).ATSDR lists substances,in order of priority,that are'most commonly found at facilities on the National Priorities List(NPL)and which are determined to pose the most significant potential threat to human health due to their known or suspected toxicity and potential for human exposure at these NPL sites'. | Jiaojiao Xie Jordan R.M.Schofield Lejun Liao Hanyong Peng Jagdeesh S.Uppal Qi Zheng X.Chris Le | 2020 | Journal of Environmental Sciences2020，32，7： | 1 |
| 10 | Magnetic solid phase microextraction on a microchip combined with electrothermal vaporization-inductively coupled plasma mass spectrometry for determination of Cd, Hg and Pb in cells 显示文摘 | Chen Beibei Heng Shujing Peng Hanyong | 2010 | J Anal At Spectrom2010，25，： | 1 |
| 11 | Screening Environmental Pollutants Binding Aptamers through Capture-SELEX for Biosensing Assays:Challenges and Opportunities显示文摘The increasing need to monitor emergent pollutants,such as persistent organic pollutants,endocrine disruptors,and antibiotics,is driven by their impacts on environment and health.1,2 Nevertheless,instrumental methods based on mass spectrometry are intricate,take a considerable amount of time,and necessitate costly equipment,posing challenges for their application in field monitoring.The development of biosensors has offered a prompt,sensitive,selective,and real-time technique for the identification and monitoring of pollutants.A bioreceptor,a transducer,and a signal processor compose a biosensor,which transforms the recognition of target into detectable signals.3 The performance of biosensors relies heavily on the bioreceptor as its binding affinity and specificity are vital determinants.The most frequently used biosensors are developed with antibodies as bioreceptors that detect environmental pollutants effectively.This is due to their high specificity and binding affinity to analytes,which results from antigen−antibody immune interactions.However,screening antibodies with high specificity and affinity can be a challenging process in biosensor development for diverse pollutants.Furthermore,these antibodies may not always maintain a constant recognition performance in a harsh environmental matrix.Therefore,development of new bioreceptors with a rapid screening method that are reliable and cost-effective is essential for improving the convenience in on-site monitoring of environmental pollutants. | Xiaoyan Wang Wenjing Xie Hanyong Peng | 2023 | Environment & Health2023，1，2： | 0 |
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