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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | Immunoreactivity of CD45,a protein phosphotyrosine phosphatase,in Alzheimer' s disease 显示文摘 | Masliah E Mallory M Hansen L Alford M Albright T Terry R | 1991 | Acta Neuropathol( Berl )1991，83，1： | 2 |
| 3 | Global discrimination of land cover types from metrics derived from AVHRR pathfinder data 显示文摘 | DEFRIES R HANSEN M TOWNSHEND J | 1995 | Remote Sensing Environment1995，54，： | 2 |
| 4 | 西双版纳傣族及上海汉族群体HLA-DR2相关的DR/DQ单倍型分析显示文摘对44名西双版纳傣族和9名上海地区汉族DK2阳性个体进行了与其相关的DR/DQ单倍型组合的分析。傣族群体中DRBI-DR2亚型分布以*1602与*1502为最常见,其等位基因频率分别为43.6%与,40.0%和汉族群体中以*1501为主明显不同。傣族群体中共检出10种与DR2相关联的DR/DQ单倍型;最常见的是DRB1*1602、DRB5*0101、DQA1*0102、DQB1*0502(34.5%)与汉族及其他群体明显不同,本研究表明傣族不仅具有高频率的DR2,而且与DR2相关联的DRB1、DRB5、DQA1、DQB1单倍型组合有其独特性。 | 范丽安 杨珏琴 姚芳娟 董建中 许玲娣 陈仁彪 M Sirkong R Vongrathna P Longta S Lekmak D Chandanayingyong A Smith J Hansen | 1995 | 中华医学遗传学杂志1995，12，3： | 2 |
| 5 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 6 | Early on-treatment prediction of response to peginterferon alfa-2a for HBeAg-negative chronic hepatitisB using HBsAg and HBV DNA levels 显示文摘 | Rijckborst V Hansen BE Cakaloglu Y Ferenci P Tabak F Akdogan M Simon K Akarca US Flisiak R Verhey E Van Vuuren AJ Boucher CA ter Borg MJ Janssen HL | 2010 | Hepatology2010，52，2： | 1 |
| 7 | Different knowledge, different benefits: Toward a productivity perspective on knowle- dge sharing in organizations显示文摘 | Haas M R Hansen M T | 2007 | Strategic Management Journal2007，28，11： | 1 |
| 8 | Mediators of inflamma- tion in the early and late phase of allergic rhinitis显示文摘 | Hansen I Klimek L M?sges R | 2004 | Curr Opin Allergy Clin Immunol2004，4，3： | 1 |
| 9 | p53: from inductive signal to cellular effect显示文摘 | HANSEN R OREN M | 1997 | Current Opinion in Genetics & Development1997，7，1： | 1 |
| 10 | Supercritical fluid transport- chemical deposition of films显示文摘 | Hansen B N Hybertson B M Barkeley R M | 1992 | Chem Mater1992，，4： | 1 |
| 11 | A quick anti-Xa-activity-based whole, blood coagulation assay for monitoring usfractioned heparin during cardiopulmonary bypass:a pilot investigation显示文摘 | Hansen R Koster A Kukuka M | 2000 | Anesth Analg2000，2，： | 1 |
| 12 | Shrinkage-reducing admixtures and early-age desiccation in cement pastes and mortars显示文摘 | Bentz D P Geiker M R Hansen K K | 2001 | Cem Concr Res2001，31，7： | 1 |
| 13 | Intramedul!ary nailing of the distal tibia illustrated with the Expert(TM) tibia nail显示文摘 | El Attal R Hansen M Rosenberger R | 2011 | Oper Orthop Traumato12011，23，5： | 1 |
| 14 | Shrinkage reducing admixtures and early-age desiccation in cement pastes and mortars显示文摘 | Bentz D P Geiker M R Hansen K K | 2001 | Cement and Concrete Research2001，31，7： | 1 |
| 15 | Bioassay of prostate - specific antigen (PSA) using microcantilevers 显示文摘 | WU G H DATAR R H HANSEN K M | 2001 | Nature Biotechnology2001，19，9： | 1 |
| 16 | Combined-stage sintering model 显示文摘 | Hansen J D Rusin R P Teng M H | 1992 | J Am Ceram Soc1992，75，5： | 1 |
| 17 | Radiative forcing and climate response 显示文摘 | Hansen J E M Sato R Ruedy | 1997 | J Geophys Res1997，102，： | 1 |
| 18 | Assessment of the importance of sorption for steroid estrogens removal during activated sludge treatment 显示文摘 | Andersen H R Hansen M Kjolhoh J | 2005 | Chemosphere2005，61，1： | 1 |
| 19 | Early life-stage toxicity test methods for gulf toadfish ( Opsanus beta) andresults using chlorpyrifos显示文摘 | HANSEN D J GOODMAN L R CRIPE G M | 1986 | Ecoloxicology and EnvironmentalSafety1986，11，1： | 1 |
| 20 | Forcings and chaos in intera- nnual to decadal climate change 显示文摘 | Hansen J Sato M Ruedy R | 1997 | Journal of Geophysical Re- search1997，102，25： | 1 |
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