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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | Reduction and carburization of iron oxides for Fischer–Tropsch synthesis显示文摘The activation of iron oxide Fischer–Tropsch Synthesis(FTS) catalysts was investigated during pretreatment: reduction in hydrogen followed by carburization in either CO or syngas mixture, or simultaneously reduction and carburization in syngas. A combination of different complementary in situ techniques was used to gain insight into the behavior of Fe-based FTS catalysts during activation. In situ XRD was used to identify the crystalline structures present during both reduction in hydrogen and carburization. An increase in reduction rate was established when increasing the temperature. A complete reduction was demonstrated in the ETEM and a grain size dependency was proven, i.e. bigger grains need higher temperature in order to reduce. XPS and XAS both indicate the formation of a small amount of carbonaceous species at the surface of the bulk metallic iron during carburization. | Monia Runge Nielsen Asger Barkholt Moss Anton Simon Bjrnlund Xi Liu Axel Knop-Gericke Alexander YuKlyushin Jan-Dierk Grunwaldt Thomas LSheppard Dmitry EDoronkin Anna Zimina Thomas Eric Lyck Smitshuysen Christian Danvad Damsgaard Jakob Birkedal Wagner Thomas Willum Hansen | 2020 | Journal of Energy Chemistry2020，29，12： | 2 |
| 3 | Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice显示文摘Dear Editor,Hypercholesterolemia is the leading risk factor for cardiovascular diseases.Current evidence suggests that the heritability for blood cholesterol levels is high,with 40%-60%in different cohorts.1,2 Genome-wide association study(GWAS)is a powerful tool to ascertain the contribution of common genetic variants in population-wide disease variability.It has been performed extensively on blood lipids traits and hundreds of genome variants are associated with dyslipidemia.However,approximately 95%of these variants are located in genome noncoding regions and cluster in more than 300 loci in different populations. | Fangfang Han Xiao Liu Chuanfang Chen Yinan Liu Mingkun Du Yu Zhou Yong Liu Bao-Liang Song Housheng Hansen He Yan Wang | 2020 | Cell Research2020，30，4： | 2 |
| 4 | Geometrically necessary boundaries and incidental dislocation boundaries formed during cold deformation 显示文摘 | Liu Q Hansen N | 1995 | Scripta Metallurgiea et Materialia1995，32，8： | 1 |
| 5 | Some chemical and physical properties of nisin,a small-protein antibiotic produced by Lactococcus lactis显示文摘 | Liu W Hansen JN | | 0，，： | 1 |
| 6 | Development of the electroretinographic oscillatory potenrials in normal and ROP rats 显示文摘 | Liu K Akula JD Hansen RM Moskowitz A Kleinman MS Fulton AB | 2006 | Invest Ophthalmol Vis Sci2006，47，12： | 1 |
| 7 | Dislocation boundary formation in a cold-rolled cube-oriented A1 single crystal 显示文摘 | Wert J A Liu Q Hansen N | 1997 | Acta Materialia1997，45，6： | 1 |
| 8 | Effect of grain orientation on deformation structure in cold-wiled polycrystalline aluminium 显示文摘 | LIU Q HANSEN N | 1998 | Acta Metall Mater1998，36，16： | 1 |
| 9 | Effect of Grain Orientation on Deformation Structure in Cold-rolled Polycrystalline Aluminum显示文摘 | Liu Q Juul Jensen D and Hansen N | 1998 | Acta mater1998，46，： | 1 |
| 10 | Using real-time PCR to determine transgene copy number in wheat显示文摘 | Zhiwu Li Jennifer L. Hansen Ying Liu Robert S. Zemetra Philip H. Berger | | 0，2004，： | 1 |
| 11 | Some chemical and physical properties of nisin, a small-protein antibiotic produced by Lactococcus Lactis 显示文摘 | Liu W Hansen J | 1990 | App Environ Microb1990，56，8： | 1 |
| 12 | Combined yeast-derived β-glucan with anti-tumor monoclonal antibody for cancer immunotherapy 显示文摘 | Liu J Gunn L Hansen R | 2009 | Exp Mol Pathol2009，86，3： | 1 |
| 13 | Some chemical and physical properties of rtisin, a small-protein antibiotic produced by Lactococcus lactis显示文摘 | LIU W HANSEN J N | 1990 | Applied and Environmental Microbiology1990，56，8： | 1 |
| 14 | Scenaricrbased management of air traffic flow: developing and using capacity scenario trees显示文摘 | LIU P C B HANSEN M MUKHERJEE A | 2006 | Transportation Research Record2006，，1951： | 1 |
| 15 | Conversion of bacillus subtilis 168 to a subtilin producer by competence transformation 显示文摘 | LIU W HANSEN J N | 1991 | Journal of Bacteriology1991，173，22： | 1 |
| 16 | Effect of grain orientation on deformation structure in cold-rolled polycryatalline aluminium显示文摘 | Liu Q Juul Jensen D Hansen N | 1998 | Acta mater1998，46，： | 1 |
| 17 | Stored Energy,Microstructure,and Flow Stress of Deformed Metals显示文摘 | Godfrey A Cao WQ Hansen N and Liu Q | 2005 | Metallurgical and Materials Transactions A2005，36，： | 1 |
| 18 | Scenario-based air traffic flow management-from theory to practice 显示文摘 | LIU P B HANSEN M MUKHERJEE A | 2008 | Transportation Research2008，，42： | 1 |
| 19 | Geometrically Necessary Boundary and Incidental Dislocation Boundary Formed during Cold Deformation显示文摘 | Liu Q Hansen N | 1995 | Scr Metall Mater1995，32，8： | 1 |
| 20 | Some chemical and physical properties of nisin, a small-protein antibiotic produced by Lactococcus lactis 显示文摘 | Liu W Hansen J N | 1990 | Appl Envical1990，56，8： | 1 |
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