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| 1 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 2 | Vaginal childbirth and pelvic floor disorders 显示文摘 | MEMON H U HANDA V L | 2013 | Women''s Health ( London England)2013，9，3： | 1 |
| 3 | Comparative analysis of various cytohistological techniques in diagnosis of lung diseases 显示文摘 | Garg S Handa U Mohan H | 2007 | Diagn Cytopatho12007，35，1： | 1 |
| 4 | Comparative analysis of various cytohistological techniques in diagnosis of lung diseases显示文摘 | Garg S Handa U Mohan H Janmeja A K | 2007 | Diagn Cytopathol2007，35，： | 1 |
| 5 | Comparative analysis of various eytohistological techniques in diagnosis of lung diseases 显示文摘 | Garg S Handa U Mohan H | 2007 | Diagn Cytopathot2007，35，1： | 1 |
| 6 | Epidermal inclusion cyst:cytomor-phological features and differential diagnosis显示文摘 | Handa U Chhabra S Mohan H | 2008 | Diagn Cytopathol2008，36，： | 1 |
| 7 | Comparative analysis of various cytohistological techniques in diagnosis of lung diseases 显示文摘 | Garg S Handa U Mohan H | 2007 | Diagn Cytopathol2007，35，1： | 1 |
| 8 | Bcl-2 and c-myc expression, cell cycle kinetics and apoptosis during the progression of chronic myelogenous leukemia from diagnosis to blastic phase显示文摘 | Handa H Hegde U P Kotelnikov V M | 1997 | Leukemia Researsh1997，21，： | 1 |
| 9 | Comparative analysis of various cytohistological techniques in diagnosis of lung diseases显示文摘 | Garg S Handa U Mohan H Janmeja A K | 2007 | Diagn Cytopathol2007，35，： | 1 |
| 10 | Engineering of SV40-based nano-capsules for delivery of heterologous proteins as fusions with the minor capsid proteins VP2/3 显示文摘 | lnoue T Kawano M A Takahashi R U Tsukamoto H Enomoto T Imai T Kataoka K and Handa H | 2008 | Journal ofBiotechnology2008，134，12： | 1 |
| 11 | Role of sensory input and muscle strength in maintenance of balance,gait,and posture in Parkinson's dis-ease:A pilot study显示文摘 | Nallegowda M Singh U Handa G | | 0，，12： | 1 |
| 12 | Role of sensory input and muscle strength in maintenance of balance,gait,and posture in Parkinson's disease:a pilot study显示文摘 | Nallegowda M Singh U Handa G | 2004 | Am J Phys Med Rehabil2004，83，： | 1 |
| 13 | Role of sensory input and muscle strength in maintenance of balance, gait, and pos- ture in Parkinson's disease: a pilot study显示文摘 | Nallegowda M Singh U Handa G | 2004 | Am J Phys Med Re- habil2004，83，12： | 1 |
| 14 | Parapharyngeal paraganglioma:diagnosis on fine-needle aspiration显示文摘 | HANDA U BAL A MOHAN H | | 0，，05： | 1 |
| 15 | Vaginal childbirth and pelvic floor disorders 显示文摘 | MEMON H U HANDA V L | 2013 | Women''s Health (London England)2013，9，3： | 1 |
| 16 | Sarcomatoid carcinoma of the cervix: case report of a rare entity显示文摘 | Mohan H Garg S Handa U | 2008 | Arch Gynecol Obstet2008，277，6： | 1 |
| 17 | Role of fine-nee- dle aspiration cytology in tuberculosis of bone显示文摘 | Handa U Garg S Mohan H | 2010 | Diagn Cytopathol2010，38，1： | 1 |
| 18 | Epidermal inclusion cyst: cytomorphological features and differential diagnosis显示文摘 | Handa U Chhabra S Mohan H | 2008 | Di agn Cytopathol2008，36，12： | 1 |
| 19 | Parapharyngeal paragangliorna: diagnosis on fine-needle aspirafion显示文摘 | Handa U Bal A Mohan H | 2005 | Am J Otolaryngol2005，26，5： | 1 |
| 20 | Epidermal inclusion cyst:cytomorphological features and differential diagnosis显示文摘 | HANDA U CHHABRA S Mohan H | 2008 | Diagn Cytopathol2008，36，12： | 1 |
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