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| 1 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 2 | Effect of Nionthe ion selectivity of rust layer on low alloy steel显示文摘 | ChenX DongJ HanE H etal | 2007 | Ma terials Letters2007，61，： | 1 |
| 3 | Imidazo triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors 显示文摘 | HANING H NIEWOHNER U SCHENKE T | 2002 | Bioorg Med Chem Lett2002，12，6： | 1 |
| 4 | Pressure dependence of resonance characteristics of the microcantilever fabricated from optical fiber 显示文摘 | Kumazaki H Inaba S Hane K | 1996 | Vacuum1996，47，： | 1 |
| 5 | Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal 显示文摘 | Lienhardt C Fielding K Hane AA Niang A Ndao CT Karam F Fletcher H Mbow F Oomis JF Diadhiou R Toupane M Dieye T Mboup S | 2010 | PLoS One2010，5，10： | 1 |
| 6 | Comparisons of physical experiment and discrete element simulations of sheared granular materials in an annular shear cell显示文摘 | JI S Y HANES D M SHEN H H | 2009 | Mechanics of Materials2009，41，6： | 1 |
| 7 | Tuberculosis and diabetes显示文摘 | Toure NO Dia Kane Y Diatta A Ba Diop S Niang H Ndiaye EM Thiam K Mbaye FB Hane AA | 2007 | Rev Mal Respir2007，24，7： | 1 |
| 8 | Using Branch-and-Price-and-Cut to solve origin-destination integer multi-commodity flow problems显示文摘 | Barnhart C Hane C A Vance P H | 2000 | Opns Res2000，48，2： | 1 |
| 9 | Comparisons of physical experiment and discrete element simulations of sheared granular materials in an annular shear cell 显示文摘 | Ji S Y Daniel M Hanes Hayley H Shen | 2009 | Mechanics of Materials2009，41，6： | 1 |
| 10 | Phosphodiesterase type 5 ( PDE5 ) inhibitors 显示文摘 | Haning H Niewohner U Bischoff E | 2003 | Prog Med Chem2003，41，： | 1 |
| 11 | Vardenafil-a potent and selective inhibitor of phosphodiesterase type 5 increases cGMP in rabbit corpus caver-nosum显示文摘 | Bischoff E Niewoehner U Haning H | 2000 | Int J Impot Res2000，12，3： | 1 |
| 12 | CCL28 effects on periodontal pathogens显示文摘 | Watkins H R Lapp C A Hanes P J | | 0，，12： | 1 |
| 13 | Comparison of field observations of the vertical distribution of suspended sand and its prediction by models显示文摘 | Lee T H Hanes D M | 1996 | Journal of Geophysical Research1996，101，： | 1 |
| 14 | Development of a sensitive two-site immunoradiometric assay for parathyroid hormonerelated peptide: evidence for elevated levels in plasma from patients with adult T-cell Leukemia/lymphoma and B-cell lymphoma显示文摘 | Ohno H Hane M | 1994 | J Clin Endocrinol Metab1994，79，5： | 1 |
| 15 | Direct inversion method to measure the concentration profile of suspended particles using backscattered sound显示文摘 | Lee T H and Hanes D M | 1996 | Journal of Geophysical Research1996，100，： | 1 |
| 16 | The effect of hydrocortisone on immature rainbow trout (Salmo gairdneri)显示文摘 | Hane S Wexler D C | 1963 | Gen Comp Endocrinol1963，3，： | 1 |
| 17 | Using branch-and-price- and-cut to solve origin-destination integer muhicommodity flow problems 显示文摘 | Barnhart C Hane C A Vance P H | 2000 | Operations Research2000，48，2： | 1 |
| 18 | The effect of hydrocorti- sone on immature rainbow trout ( Salmo gairdneri) 显示文摘 | Robertson 0 H Hane S Wexler D C | 1963 | Gen Comp Endocrinol1963，3，： | 1 |
| 19 | Inhibition of MMP synthesis by doxycycllne and chemically modified tetracyclines(CMTs) in human endothelial cells显示文摘 | Hane MR Visser H Koolwijk P | 1998 | Adv Dent Res1998，12，2： | 1 |
| 20 | The oral efficacy of vardenafil hvdrochloride for inducing penile erection in a conscious rabbit model显示文摘 | Bischoff E Niewohner U Haning H | 2001 | J Urol2001，165，4： | 1 |
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