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| 1 | Role of gamma-delta T cells in liver inflammation and fibrosis显示文摘Conventional adaptive T cell responses contribute to liver inflammation and fibrogenesis,especially in chronic viral infections and autoimmune hepatitis.However,the role of unconventional gamma-delta(γδ)T cells in liver diseases is less clear.In the past two decades,accumulating evidence revealed thatγδT cell numbers remarkably increase in the liver upon various inflammatory conditions in mice and humans.More recent studies demonstrated that the functional effect ofγδT cells on liver disease progression depends on the subsets involved,which can be identified by the expression of distinct T cell receptor chains and of specific cytokines.Fascinatingly,γδT cells may have protective as well as pathogenic functions in liver diseases.Interferonγ-producingγδT cells,for example,induce apoptosis in hepatocytes but also in hepatic tumor cells;while interleukin-17-expressingγδT cells can downregulate pathogenic effector functions of other immune cells and can promote apoptosis of fibrogenic stellate cells.However,the results obtained in human liver disease as well as murine models are not fully conclusive at present,and the effects ofγδT cells on the outcome of liver disease might vary dependent on etiology and stage of disease.Further definitions of theγδT cell subsets in-volved in acute and chronic liver inflammation,as well as their effector cytokines might uncover whether interference withγδT cells could be a useful target for the treatment of liver disease. | Linda Hammerich Frank Tacke | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，2： | 4 |
| 2 | Role of IL-17 and Th17 Cells in Liver Diseases显示文摘 | Linda Hammerich Felix Heymann Frank Tacke T. Nakayama | 2010 | Clinical and Developmental Immunology2010，，： | 2 |
| 3 | Emerging roles of myeloid derived suppressor cells in hepatic inflammation and fibrosis显示文摘Myeloid derived suppressor cells(MDSC) are a heterogeneous population of immune cells that are potent suppressors of immune responses. MDSC emerge in various compartments in the body, such as blood, bonemarrow or spleen, especially in conditions of cancer, infections or inflammation. MDSC usually express CD11 b, CD33, and low levels of human leukocyte antigen-DR in humans or CD11 b and Gr1(Ly6C/G) in mice, and they can be further divided into granulocytic or monocytic MDSC. The liver is an important organ for MDSC induction and accumulation in hepatic as well as extrahepatic diseases. Different hepatic cells, especially hepatic stellate cells, as well as liver-derived soluble factors, including hepatocyte growth factor and acute phase proteins(SAA, KC), can promote the differentiation of MDSC from myeloid cells. Importantly, hepatic myeloid cells like neutrophils, monocytes and macrophages fulfill essential roles in acute and chronic liver diseases. Recent data from patients with liver diseases and animal models linked MDSC to the pathogenesis of hepatic inflammation, fibrosis and hepatocellular carcinoma(HCC). In settings of acute hepatitis, MDSC can limit immunogenic T cell responses and subsequent tissue injury. In patients with chronic hepatitis C, MDSC increase and may favor viral persistence. Animal models of chronic liver injury, however, have not yet conclusively clarified the involvement of MDSC for hepatic fibrosis. In human HCC and mouse models of liver cancer, MDSC are induced in the tumor environment and suppress anti-tumoral immune responses. Thus, the liver is a primary site of MDSC in vivo, and modulating MDSC functionality might represent a promising novel therapeutic target for liver diseases. | Linda Hammerich Frank Tacke | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，3： | 2 |
| 4 | Origin of regenerating tubular cells after acute kidney injury 显示文摘 | Berger K Bangen JM Hammerich L et at | 2014 | Proc Nati Acad Sei2014，111，4： | 1 |
| 5 | Role of IL-17 and Th17 Cells in Liver Diseases显示文摘 | Linda Hammerich Felix Heymann Frank Tacke T. Nakayama | 2010 | Clinical and Developmental Immunology2010，，： | 1 |
| 6 | Chemokine receptor CCR6-dependent accumulation ofγδT cells in injured liver restricts hepatic inflammation and fibrosis显示文摘 | Hammerich L Bangen JM Govaere O | 2014 | Hepatology2014，59，2： | 1 |
| 7 | Kidneydendritic cells become pathogenic during crescentic glomerulone-phritis with proteinuria显示文摘 | HOCHHEISER K ENGEL D R HAMMERICH L | 2011 | J Am Soc Nephrol2011，22，2： | 1 |
| 8 | Hepatic maerophage mi- gration and differentiation critical for liver fibrosis is mediated by /he chemokine receptor C-C motif ehemokine receptor 8 in mice 显示文摘 | Heymann F Hammerich L Storch D | 2012 | Hepatology2012，55，3： | 1 |
| 9 | Interleukins in chronic liverdisease: lessons learned from experimental mousemodels 显示文摘 | Hammerich L Tacke F | 2014 | Clin Exp Gastroenterol2014，7，： | 1 |
| 10 | Interleukins in chronic liver disease: lessons learned from experimental mouse models显示文摘 | Hammerich L Tacke F | 2014 | Clin Exp Gastroenterol2014，7，： | 1 |
| 11 | Chemokine receptor CCR6-dependent accumulation ofγδT cells in injured liver restricts hepatic inflammation and fibrosis显示文摘 | Hammerich L Bangen JM Govaere O | 2014 | Hepatology2014，59，2： | 1 |
| 12 | Neither Long-Term Statin Use nor Atherosclerotic Disease Is Associated With Risk of Colorectal Cancer显示文摘 | Douglas J. Robertson Anders Hammerich Riis S?ren Friis Lars Pedersen John A. Baron Henrik Toft S?rensen | 2010 | Clinical Gastroenterology and Hepatology2010，，12： | 1 |
| 13 | Role of IL-17 and Thl7 cells in liver diseases 显示文摘 | Hammerich L Heymann F Tacke F | 2011 | Clin Dev Immunol2011，2011，34： | 1 |
| 14 | Malignant advanced granulosa cell tumor of the adult testis : case report and review of the literature显示文摘 | Hammerich KH Hille S Ayala GE | 2008 | Hum Pathol2008，39，5： | 1 |
| 15 | On electric conductivity of infinite clusters in water-in-oil microemulsion显示文摘 | Eicke H F Meier W Hammerich H | 1994 | Langmuir1994，10，： | 1 |
| 16 | Determining prostate cancer-specific death through quantification of stromogenic carcinoma area in prostatectomy specimens 显示文摘 | Ayala GE Muezzinoglu B Hammerich KH | 2011 | Am J Pathol2011，178，1： | 1 |
| 17 | Role of IL-17 and Thl7 cells in liver diseases 显示文摘 | Hammerich L Heymann F Tacke F | 2011 | Clin Dev Immunol2011，201，34： | 1 |
| 18 | Chemokine receptor CCR6-dependent accumulation of gammadeha T-cells in injured liver restricts hepatic inflammation and fibrosis 显示文摘 | HAMMERICH L BANGEN J M GOVAERE O | 2014 | Hepatology2014，59，2： | 1 |
| 19 | Met-CCL5 modifies mono- cyte subpopulations during liver fibrosis regression 显示文摘 | Stock M K Hammerich L T do O N | 2013 | Int J Clin Exp Pathol2013，6，4： | 1 |
| 20 | Hepatic macrophage migration anddifferentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice 显示文摘 | Heymann F Hammerich L Storch D | 2012 | Hepatology2012，55，3： | 1 |
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