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| 1 | Reconstructing the Primordial Spectrum of Fluctuations of the Universe from the Observed Nonlinear Clustering of Galaxies显示文摘 | Hamilton A J S Kumer P Lu E | 1991 | ApJ1991，374，： | 3 |
| 2 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 3 | An integrated anal ytical approach for determining the origin of solid bitumens in the McArthur Basin,Northern Australia显示文摘 | George S C Llorca S M Hamilton P J | 1994 | Org Geochem1994，21，： | 1 |
| 4 | Natural occurrences of ochratoxicosis in poultry显示文摘 | Hamilton P A T B Huff W E Harris J R A Y | 1982 | Poultry Science1982，61，9： | 1 |
| 5 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois K A Gilles J K Hamilton P A | 1956 | Anal Chem1956，28，3： | 1 |
| 6 | The relationship of surface pressure fea- tures to the precipitation and airflow structure of an intense midlatitude squall line 显示文摘 | Johnson R H Hamilton P J | 1988 | Mon Wea Rev1988，116，7： | 1 |
| 7 | The production and emission of nitrous oxide from headwater streams in the midwestern United States显示文摘 | Beaulieu J J Arango C P Hamilton S K | 2008 | Global Change Biology2008，14，4： | 1 |
| 8 | Use of a ramp velocity test to measure critical swimming speed in Rainbow trout (Oncorhynchus mykiss) 显示文摘 | Jain K E Hamilton J C Farrell A P | 1997 | Comparative Biochemistry Physiology1997，117，： | 1 |
| 9 | Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis显示文摘 | Creticos P S Schroeder J T Hamilton R G | 2006 | N Engl J Med2006，355，： | 1 |
| 10 | Continental-scale magmatic carbon dioxide seepage recorded by dawsonite in the Bowen-Gunnedah-Sydney basin system,eastern Australia 显示文摘 | Baker J C Bai G P Hamilton P J | 1995 | Journal of Sedimentary Research1995，65，3： | 1 |
| 11 | Colorimetric methods for determination of sugars and related substances 显示文摘 | DOBOIS M A HAMILTON J K REBERS P A | 1956 | Analytical Chemistry1956，28，3： | 1 |
| 12 | Effect of temperature and pH on the effective maximum specific growth rate of nitrifying bacteria 显示文摘 | ANTONIOU P HAMILTON J KOOPMAN B | 1990 | Water Research1990，24，1： | 1 |
| 13 | Dietary exposure of broiler breeders to aflatoxin results in immune dysfunction in progeny chicks显示文摘 | QURESHI M A BRAKE J HAMILTON P B | 1998 | Poultry Science1998，77，6： | 1 |
| 14 | A Sm-Nd study of atmospheric dusts and particulates from major river systems显示文摘 | GOLDSTEIN S L O'NIONS R K HAMILTON P J | 1984 | Earth Planet Sci Lett1984，70，： | 1 |
| 15 | Three-dimensional modelling of a Microeystis bloom event in the Swan River estuary, Western Australia 显示文摘 | Robson B J Hamilton D P | 2004 | Ecological Modelling2004，174，： | 1 |
| 16 | Reconstructing the Primordial Spectrmn of Fluctuations of the Universe from the Observed Nonlinear Clustering of Galaxies显示文摘 | Hamilton A J S Kumer P Lu E | 1991 | ApJ1991，374，： | 1 |
| 17 | Effect of curing on the chemical composition of burleytobacco显示文摘 | Burton H R Bush L P Hamilton J L | 1983 | Recent Adv Tobacco Science1983，9，： | 1 |
| 18 | Fluid history analysis-A new concept for prospect evaluation 显示文摘 | Eadington P J Hamilton P J | 1991 | Australian Petroleum Exploration Association Journal1991，12，3： | 1 |
| 19 | The relationship of surface pressure features the precipitation and air flow structure of an intense midlatitude squall line显示文摘 | Johnson R H Hamilton P J | 1988 | Mon Wea Rev1988，116，： | 1 |
| 20 | Garcia-Hernandes显示文摘 | Hamilton P B Tirado F J | 1990 | Poultry Science1990，69，： | 1 |
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