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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | A study of quality of life inprimigravidae with urinary incontinence显示文摘 | Dolan LM Walsh D Hamilton S | 2004 | Int Urogynecol J PelvicFloor Dysfunct2004，15，3： | 1 |
| 3 | C-2 neurec-tomy during atlantoaxial instrumented fusion in the elderly: patient satisfaction and surgical outcome 显示文摘 | Hamilton D K Smith J S Sansur C A | 2011 | J Neurosurg Spine2011，15，1： | 1 |
| 4 | The increasing linkage between US technology and public science 显示文摘 | Narin F Hamilton K S Olivastro D | 1997 | Research Policy1997，26，3： | 1 |
| 5 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 6 | An EWMA for monitoring a process standard deviation显示文摘 | CROWDER S V HAMILTON M D | | 0，，01： | 1 |
| 7 | Feline ilial fractures:assessment of screw loosening and pelvic canal narrowingafter lateral plating显示文摘 | Hamilton M H Evans D A Langley-Hobbs S J | 2009 | Vet Surg2009，38，： | 1 |
| 8 | The potential of virtual laryngoscopy in the assessment of vocal cord lesions显示文摘 | Walshe P Hamilton S McShane D | 2002 | Clin Otolaryngol Allied Sci2002，27，2： | 1 |
| 9 | Brillouin scattering measurement on optical glasses显示文摘 | Heiman D Hamilton D S Hellwarth R W | 1979 | Phy Rev B1979，19，12： | 1 |
| 10 | Multi-model integration in decision support system:a technical user interface approach for watershed and lake management scenarios显示文摘 | LAM D LEON L HAMILTON S | | 0，，03： | 1 |
| 11 | Left ventricular thrombus enhancement after intravenous injection of echogenic immunoliposomes: studies in a new experimental model显示文摘 | Hamilton A Huang S L Warnick D | 2002 | Circulation2002，105，23： | 1 |
| 12 | Convention- al in-vitro fertilisation versus intracytoplasmic sperm in- jection for the treatment of non-malefactor infertility:a ran- domised controlled trial显示文摘 | Bhattacharya S Hamilton MP Shaaban M et d | 2001 | Lancet2001，357，9274： | 1 |
| 13 | Left ventricular thrombus enhancement following intravenous injection of eehogenic immunoliposomes: studies in a new experimental model显示文摘 | Hamilton A Huang S L Wamick D | 2002 | Circulation2002，105，： | 1 |
| 14 | Modelling the impact of zooplankton grazing on phytoplankton biomass during a dinoflagellate bloom in the Swan River Estuary, Western Australia 显示文摘 | Griffm S L Herzfeld M Hamilton D P | 2001 | Ecological Engineering2001，162，： | 1 |
| 15 | Olanzapine versus placebo and haloperidol:Quality of life and efficacy results of the north American double-blind trial显示文摘 | Hamilton S H Revicki D A Genduso L A | 1998 | Neuropsychopharmacology1998，18，1： | 1 |
| 16 | Management of massive blood loss: a template guideline显示文摘 | MacLennan S Hamilton PJ | 2000 | Br J Anaesth2000，85，3： | 1 |
| 17 | Climate change and international tourism: A simulation study 显示文摘 | Hamilton J M Maddison D J Richard S J | 2005 | Global Environmental Change2005，15，3： | 1 |
| 18 | Increased obese mRNA expression in omental fat cells from massively obese humans显示文摘 | Hamilton B S Paglia D Kwan AY | 1995 | Nat Med1995，，9： | 1 |
| 19 | Approaches to identifying reservoir heterogeneity and reserve growth opportunities in a continental-scale bed-load fluvial system: hutton sandstone, Jackson field, Australial显示文摘 | HAMILTON D S HOLTZ M H RYLES P | 1998 | AAPG Bulletin1998，82，12： | 1 |
| 20 | Farnesyhransferase and geranylgeranyl- transferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies 显示文摘 | Sebti S M Hamilton A D | 2000 | Oncogene2000，19，56： | 1 |
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