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| 1 | Invasive group B streptococcal infection in a patient with post splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension显示文摘BACKGROUND:Splenectomy in patients with liver cirrhosis(LC)is expected to become more common owing to its efficacy on portal hemodynamics.In this report we describe an alarming case of group B streptococcus(GBS)infection after splenectomy in a patient with LC.METHODS:A 72-year-old woman with a history of LC was admitted to our emergency department because of respiratory failure.The patient had received left lateral segmentectomy of the liver and splenectomy three months before admission.Pulmonary examination revealed significant wheezing during inspiration and expiration,but no crackles and stridor.Chest radiography and CT showed no infiltrates.A presumptive diagnosis of bronchial asthma caused by upper respiratory infection was made.Four days after admission,GBS infection was confirmed by blood culture and penicillin G was administered.Antibiotics were given intravenously for a total of 12 days.RESULTS:The patient was discharged on the 12th day after admission.CONCLUSIONS:Although efficacy of splenectomy in patients with LC has been reported,immune status should be evaluated for a longer period.Patients who have undergone splenectomy are highly susceptible to bacteria;moreover,LC itself is an independent risk factor for mortality in patients with sepsis.Since prophylaxis against GBS has not been established,immediate action should be taken.Emergency physicians should be aware of invasive GBS infection in the context of the critical risk factors related to splenectomy and LC,particularly the expected increase of splenectomy performed in LC patients. | Tomoya Okazaki Toru Hifumi Arisa Manabe Hikari Matsumura Satoshi Egawa Hideyuki Hamaya Nastuyo Shinohara Koshiro Takano Hajime Shishido Yuko Abe Kenya Kawakita Masanobu Hagiike Yasuhiro Kuroda | 2016 | World Journal of Emergency Medicine2016，7，1： | 6 |
| 2 | Inverted Meckel's diverticulum preoperatively diagnosed using double-balloon enteroscopy显示文摘An inverted Meckel's diverticulum is a rare gastrointestinal congenital anomaly that is difficult to diagnose prior to surgery and presents with anemia, abdominal pain, or intussusception. Here, we report the case of 57-year-old men with an inverted Meckel's diverticulum, who was preoperatively diagnosed using doubleballoon enteroscopy. He had repeatedly experienced epigastric pain for 2 mo. Ultrasonography and computed tomography showed intestinal wall thickening in the pelvis. Double-balloon enteroscopy via the anal route was performed for further examination, which demonstrated an approximately 8-cm, sausage-shaped, submucosal tumor located approximately 80 cm proximal to the ileocecal valve. A small depressed erosion was observed at the tip of this lesion. Forceps biopsy revealed heterotopic gastric mucosa. Thus, the patient was diagnosed with an inverted Meckel's diverticulum, and single-incision laparoscopic surgery was performed. This case suggests that an inverted Meckel's diverticulum should be considered as a differential diagnosis for a submucosal tumor in the ileum. Balloon-assisted enteroscopy with forceps biopsy facilitate a precise diagnosis of this condition. | Kosuke Takagaki Satoshi Osawa Tatsuhiro Ito Moriya Iwaizumi Yasushi Hamaya Hiroe Tsukui Takahisa Furuta Hidetoshi Wada Satoshi Baba Ken Sugimoto | 2016 | World Journal of Gastroenterology2016，22，17： | 2 |
| 3 | Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction:A case report显示文摘BACKGROUND Tuberous sclerosis complex(TSC)is a rare inherited disease with non-cancerous tumor growths in the skin,brain,kidneys,heart,and lungs.The co-occurrence of neuroendocrine neoplasm(NEN)with TSC is even rarer.There have been few reports on the relationship between TSC and neuroendocrine tumors(NETs),and fewer on the relationship between TSC and neuroendocrine carcinoma(NEC),a subtype of NEN.This is the first reported case of NEC occurring at the esophagogastric junction in a patient with TSC.CASE SUMMARY A 46-year-old woman visiting our hospital for the treatment of TSC was admitted to the emergency department with tarry stools and dizziness.Computed tomography scans revealed thickness of the gastric cardia,multiple metastatic lesions of the liver,and enlarged lymph nodes near the lesser curvature of the stomach.Esophagogastroduodenoscopy revealed a type 3 tumor located from the esophagogastric junction to the fundus,and the pathological diagnosis by biopsy was NEC.The patient was treated with seven courses of cisplatin+irinotecan,followed by eight courses of ramucirumab+nab-paclitaxel,one course of nivolumab,and two courses of S-1+oxaliplatin.Twenty-three months after the first treatment,the patient died because of disease progression and deterioration of the general condition.CONCLUSION This case of NEC occurring in a patient with TSC indicates a difference in the occurrence of NETs and NECs. | Natsuki Ishida Takahiro Miyazu Satoshi Tamura Satoshi Suzuki Shinya Tani Mihoko Yamade Moriya Iwaizumi Satoshi Osawa Yasushi Hamaya Kazuya Shinmura Haruhiko Sugimura Katsutoshi Miura Takahisa Furuta Ken Sugimoto | 2020 | World Journal of Gastroenterology2020，26，45： | 2 |
| 4 | Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells显示文摘 | Stephanie Tseng-Rogenski Yasushi Hamaya Dan Y. Choi John M. Carethers | 2014 | Gastroenterology2014，，： | 2 |
| 5 | Differences in cardiovascular response to airway stimulation at different sites and blockade of the responses by lido- caine显示文摘 | Hamaya Y Dohi S | 2000 | Anesthesiology2000，93，1： | 1 |
| 6 | Camellidins, antifungal saponins isolated from Camellia japonica显示文摘 | Nagata T Tsushida T Hamaya E | 1985 | Agricultural and Biological Chemistry1985，49，： | 1 |
| 7 | In vitro magnetite formation by urease dependent reaction显示文摘 | Hamaya T Horikoshi K | 1989 | Agric Biol Chem1989，53，3： | 1 |
| 8 | Differences in cardiovascular response to airway stimulation at different sites and blockade of the responses by lidocaine显示文摘 | Hamaya Y Dohi S | 2000 | Anesthesiology2000，93，： | 1 |
| 9 | Evidence for osteoporosis treatment using PTH (1-34) daily subcutaneous injection 显示文摘 | Yamamoto T Hamaya E Sowa H | 2012 | Clin Calcium2012，22，3： | 1 |
| 10 | 显示文摘 | Hamaya T Hiratani K Ohashi K | 1994 | Macromol Chem Phys1994，195，8： | 1 |
| 11 | Differences in cardiovascular response to airway stimulation at different sites and blockade of the responses by lidocaine显示文摘 | Hamaya Y Dohi S | 2000 | Anesthesiology2000，93，1： | 1 |
| 12 | 87 Reexpansion pulmonary ede ma after thoracoscopic mediastinal tu mor resection显示文摘 | Yanagidate F Dohi S Hamaya Y | 2001 | Anesth Analg2001，92，6： | 1 |
| 13 | Differences in cardiovascular response to airway stimulation at different sites and blockade of the responses by lidocaine显示文摘 | Hamaya Y Dohi S | 2000 | Anesthesiology2000，9395，： | 1 |
| 14 | Teriparatide : human re- combinant parathyroid hormone (1-34) as a daily subcu- taneous injection 显示文摘 | Sowa H Hamaya E Yamamoto T | 2011 | Clin Calcium2011，21，1： | 1 |
| 15 | Differences in cardiovascular response to airway stimulation at different sites and blockade of the responses by lidocaine显示文摘 | Hamaya Y Dohi S | | 0，，01： | 1 |
| 16 | Susceptibility of metallothionein-null mice to paraquat显示文摘 | Sato M Apostolova M D Hamaya M | 1996 | Environmental-toxicology and Pharmacology1996，1，4： | 1 |
| 17 | Ultraviolet spectrophtometric studies of the reactivity of a water-soluble polymer containing pendant 8-hydroxyquiniline moieties with metal ions 显示文摘 | Hamaya T Hiratani K Ohashi K | 1994 | Macromolecular Chemistry and Physics1994，195，8： | 1 |
| 18 | New highly proton conductive polymer membranes poly(vinyl alcohol)/2-acry-lamido-2-methyl-1-propanesulfonic acid (PVA-PAMPS)显示文摘 | Qiao J L Hamaya T Okada T | | J Mater Chem0，，： | 1 |
| 19 | Basaloid-squamous cell carcinoma of the esophagus:diagnosis based on immunohistochemical analysis显示文摘 | Nishimura W Naomoto Y Hamaya K | 2001 | J Gastroenterol Hepatol2001，16，5： | 1 |
| 20 | Poly(vinyl alcohol)-poly(2-acrylamido-2-methyl-1-propanesulfonic acid) as a novel proton-conducting fuel cell membrane显示文摘 | Qiao J L Hamaya T Okada T | 2005 | Chem Mater2005，17，： | 1 |
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