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| 1 | Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases. | Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani | 2015 | International Journal of Oral Science2015，7，4： | 3 |
| 2 | Osteochondritis dissecans of the latcral femoral condyle of the knee joint 显示文摘 | Mitsuoka T Shino K Hamada M | 1999 | Arthroscopy1999，15，： | 2 |
| 3 | Effects of taurine levels in broodstock diet on reproductive performance of yellowtail Seriola quinqueradiata显示文摘 | Matsunari H Hamada K Mushiake K | 2006 | Fisheries Science2006，72，： | 1 |
| 4 | Early reduc- tion of infected hepatocytes by activated immunity at the time of interferon withdrawal hepatitis followed by lami- vudine administration resulted in higher seroconversion in hepatitis B e antigen-positive patients with chronic hep- atitis B显示文摘 | Shindo M Hamada K Muramatsu A | 2006 | J Gastroenterol2006，41，： | 1 |
| 5 | Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase 显示文摘 | SUMI H HAMADA H NAKANISHI K | 1990 | Acta Haematol-Basel1990，84，3： | 1 |
| 6 | Antitumor effect of erythromycin in mice显示文摘 | HAMADA K KITA E SAWAKI M | 1995 | Chemotherapy1995，41，1： | 1 |
| 7 | Therapeutic efficacy of intra-articular adrenomedullin injection in an- tigen-induced arthritis in rabbits 显示文摘 | Okura T Marutsuka K Hamada H | 2008 | Arthritis Res T- her2008，10，6： | 1 |
| 8 | Dielectric-loaded coaxial-slot antenna for interstitial microwave hyperthermia:longitudinal control of heating patterns显示文摘 | SAITO K Yoshimura H | 2000 | Int J Hyperthermia2000，16，3： | 1 |
| 9 | Dynamic magnetic resonance appearance of the vertebral dissecting aneurysms: case report 显示文摘 | Hamada J Sato K Nagahim S | 1992 | Neurol Med Chir1992，32，： | 1 |
| 10 | Production of high concentration of ethanol from inulin by simultaneous saccharification and fermentation using Aspergillus niger and Saccharomyces cerevisiae显示文摘 | Ohta K Hamada S Nakamura T | 1993 | Appl Environ Microbiol1993，59，： | 1 |
| 11 | Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase显示文摘 | Sumi H Hamada H Nakanishi K | 1990 | Acta Haematol1990，84，3： | 1 |
| 12 | Pueraria mirifica, a phytoestrogen-rich herb, prevents bone loss inorchidectomized rats显示文摘 | Urasopon N Hamada Y Asaoka K | 2007 | Maturitas2007，56，3： | 1 |
| 13 | Increased secretion of aritaI and brian natriuretic peptides during acute myocardial induced by dynamic exercise in patients with angina pectoris 显示文摘 | Marumoto K Hamada M Hiwada K | 1995 | Clin Sci(Colch)1995，88，： | 1 |
| 14 | A simple, easy and routine assay of thrombolytic enzyme activity显示文摘 | TOSHIO H HAMADA H NAKANISHI K | 1996 | Nippon Kagaku Kashi1996，43，2： | 1 |
| 15 | Investigation and threshold of optimum blood concentration of voriconazole : a descriptive statistical meta-analysis显示文摘 | HAMADA Y SETO Y YAGO K | 2012 | J Infect Chemother2012，18，4： | 1 |
| 16 | Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase 显示文摘 | SUMI H HAMADA H NAKANISHI K | 1990 | Acta Haematol1990，84，3： | 1 |
| 17 | Increased secretion of atrial and brain natriuretic peptides during acute myocardial ischaemia induced by dynamic exercise in-patients with angina pectoris显示文摘 | Marumoto K Hamada M Hiwada K | 1995 | Clin Sci(Lond)1995，88，5： | 1 |
| 18 | Influence of aging and cell senescence on telomerase activity in keratinocytes 显示文摘 | Matsui M Miyasaka J Hamada K | 2000 | J Dermatol Sci2000，22，： | 1 |
| 19 | Real-time extension for Windows NT/CE used for control systems显示文摘 | KAWAKAMI I NIMURA Y HAMADA K | 2002 | Control and Power Engineering2002，30，10： | 1 |
| 20 | Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis 显示文摘 | Inoshima Kuwano K Hamada N Yoshimi M Maeyama T Hagimoto N | 2004 | Am J Physiol2004，286，2： | 1 |
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