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| 1 | Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution显示文摘In this study, we proposed a rapid and sensitive method for quantification and spatial distribution of salicylic acid in film tablets using FT-Raman spectroscopy with multivariate curve resolution(MCR). For this purpose, the constituents of film tablets were identified by using FT-Raman spectroscopy, and then eight different concentrations of salicylic acid tablets were visualized by Raman mapping. MCR was applied to mapping data to expose the active pharmaceutical ingredients in the presence of other excipients by monitoring distribution maps and combination of FT-Raman mapping with MCR enabled the determination of lower salicylic acid concentrations. In addition, the distribution of major excipient, lactose, was examined in the tablet form. A calibration curve was obtained by plotting the intensity of the Raman signal at 1635 cm^(-1) versus the concentration of salicylic acid and the correlation was found to be linear within the range of 0.5%–3.9% with a correlation coefficient of 0.99. The limit of detection for the technique was determined 0.35%. The ability of the technique to quantify salicylic acid in tablet test samples was also investigated. | Haslet Eksi-Kocak Sibel Ilbasmis Tamer Sebnem Yilmaz Merve Eryilmaz Ismail Hakkl Boyaci Ugur Tamer | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，2： | 1 |
| 2 | Removal of methylene blue from aqueous solution using cotton stalk,cotton waste and cotton dust显示文摘 | Murat Erta(s)a Bilal Acemiǒglub M Hakkl Almaa | | 0，，： | 1 |
| 3 | Five methods for detection of Helicobacter pylori in the Turkish population显示文摘AIM: To compare culture analysis, Helicobacter pylori (H. pylori) stool antigen (HpSA) test, polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH) for H. pylori detection. METHODS: One hundred and thirty-two consecutive adult dyspeptic patients receiving diagnostic endoscopy at the department of gastroenterology were enrolled in this study. Culture and histological examination were performed on biopsy specimens. PCR and FISH tests were applied to histopathological samples. Stool samples that were simultaneously collected were tested for the H. pylori antigen using the HpSA test and bacterial DNA using stool PCR. RESULTS: H. pylori was positively identified by histo-logical examination in 85/132 (64.4%) of the patients, while positive samples were found in 56 (42.4%), 64 (48.5%), 98 (74.2%), 28 (21.2%) and 81 (61.4%) of the patients by culture, HpSA, PCR, stool PCR and FISH methods, respectively. The results of the culture, biopsy PCR, HpSA and FISH tests, with the exception of the stool PCR, were found to correlate with the histological examination as a gold standard. CONCLUSION: The HpSA test is a rapid, simple, and noninvasive test for monitoring therapy. FISH is an accurate, rapid, cost-effective, and easy-to-use test for H. pylori detection. | Orhan Cem Aktepe ihsan Hakkl Ciftci Birol Safak ihsan Uslan Fatma Husniye Dilek | 2011 | World Journal of Gastroenterology2011，17，47： | 1 |
| 4 | Effects of Sewage Sludge Application on the Heavy Metal Content of Crested Wheatgrass (Agropyron cristatum (L.)) Gaertn显示文摘 | Hakkl Akdeniz Mehmet Ali Bozkurt Omer Terzioglu Bilal Keskin | 2014 | Journal of Environmental Science and Engineering(B)2014，3，5： | 0 |
| 5 | Study on Plant Species Belonging to Fabaceae L. Family in Flora of A^lri Mountain显示文摘 | Yusif Zeynalov Hakkl Akdeniz Ibrahim Hakki Yilmaz | 2014 | Journal of Environmental Science and Engineering(A)2014，3，5： | 0 |
| 6 | Turkish Diplomacy: Becoming a Model for the Middle East显示文摘 | Mesut Hakkl Cabin | 2011 | Journalism and Mass Communication2011，1，3： | 0 |
| 7 | Turkish Early Childhood Educators' Perceptions of Child Development and Education in the Preschool Years显示文摘 | Emine Ahmetoglu Ibrahim Hakkl Acar Manolya Aslk-Ozturk | 2018 | US-China Education Review(B)2018，8，1： | 0 |
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