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| 1 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 2 | Extranodal NK/T-cell lymphoma, nasal type显示文摘 | Hakeem DA Fedele S Carlos R | 2007 | Oral Oncology2007，43，1： | 1 |
| 3 | Glycemic control,hypertension and chronic complications in type 2 diabetic subjects attending a tertiary care centre显示文摘 | Basit A Hydrie MZ Hakeem R | | 0，，02： | 1 |
| 4 | Dual Stimuli-responsive Nano-vehicles for Controlled Drug Delivery: Mesoporous Silica Nanoparticles End- capped with Natural Chitosan显示文摘 | HAKEEM A DUAN R X ZAHID F Z etal | 2014 | Chem Commun2014，50，13： | 1 |
| 5 | Extranodal NK/T - cell lymphoma, nasal type显示文摘 | AL Hakeem DA Fedele S Carlos R | 2007 | Oral Oncol2007，43，1： | 1 |
| 6 | Response of arbuscular mycorrhizal mungbean plants to ambient air pollution 显示文摘 | Nasim G Bajwa R Hakeem A | 2007 | International Journal of Environmental Science and Technology2007，4，3： | 1 |
| 7 | Glycemic control, hypertension and chronic complications in type 2 diabetic subjects attending a tertiary care center显示文摘 | Basit A Hydrie MZ Hakeem R | 2005 | J Ayub Med Coil Abbottabad2005，17，2： | 1 |
| 8 | Extrac- tion, purifcation, identification and metabolism of 3',5'cyclic-UMP, 3',5'-cyclic IMP and 3',5'-cyclic dTMP from rat tissues显示文摘 | Newton R P Kingston E E Hakeem N A | 1986 | Biochemical Journal1986，236，： | 1 |
| 9 | Kxtranodal NK/T-celllymphoma, nasal lype 显示文摘 | AL Hakeem DA Fedele S Carlos R | 2007 | Oral Oncol2007，43，： | 1 |
| 10 | Genotypic variability among soybean genotypes under NaC1 stress and proteome analysis of salt-tolerant genotype显示文摘 | Hakeem K R Khan F Chandna R | | 0，，08： | 1 |
| 11 | Genotypic variability among soybean genotypes under NaCI stress and proteome analysis of salt-tolerant genotype 显示文摘 | Hakeem K R Khan F Chandna R et at | 2012 | Applied Biochemistry and Biotechnology2012，168，： | 1 |
| 12 | Anemia and chronic kidney disease(CKD) are powerful predictors for presence and severity of coronary artery disease(CAD)显示文摘 | Cook J R Hakeem A Bhatti S | 2006 | Circula- tion2006，114，： | 1 |
| 13 | Modelling of a Turbocharger Turbine under Pulsating Inlet Conditions显示文摘 | Chen H Hakeem I Martinez-Botas R F | 1996 | Proceedings of IMechE Journal of Power and Energy1996，210，2： | 1 |
| 14 | Extranodal NK/T-cell lymphoma, nasal type 显示文摘 | AL Hakeem DA Fedele S Carlos R | 2007 | Oral Oncol2007，43，1： | 1 |
| 15 | Modeling of a turbo- charger turbine under pulsating inlet conditions显示文摘 | Chen H Hakeem I Martinez-Botas R F | 1996 | IMechE1996，210，5： | 1 |
| 16 | Extranodal NK/T-cell lymphoma,nasal type显示文摘 | Fedele S Carlos R | 2007 | Oral Oncol2007，43，1： | 1 |
| 17 | Relevance of proteomic investigations in plant abiotic stress physiology显示文摘 | Hakeem K R Chandna R Ahmad P | 2012 | OMICS: A Journal of Integrative Biology2012，16，11： | 1 |
| 18 | Development and validation of RP-HPLC method for estimation of rufinamide in bulk and its pharmaceutical dosage form显示文摘 | S Muneer C Jose Gnana Babu R Hakeem | | 0，，01： | 1 |
| 19 | Modelling of a turbocharger turbine under pulsating inlet conditions显示文摘 | Chen H Hakeem I Martinez-Botas R F | 1996 | IMechE1996，201，5： | 1 |
| 20 | Extranodal NK/T - cell lymphoma,nasal type显示文摘 | AL Hakeem D A Fedele S Carlos R | 2007 | Oral Oncology2007，43，1： | 1 |
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