| 1 | Macrophages in immunoregulation and therapeutics显示文摘Macrophages exist in various tissues,several body cavities,and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers.Macrophages possess binary M1/M2 macrophage polarization settings,which perform a central role in an array of immune tasks via intrinsic signal cascades and,therefore,must be precisely regulated.Many crucial questions about macrophage signaling and immune modulation are yet to be uncovered.In addition,the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their biology.Moreover,they are an integral part of the tumor microenvironment,playing a part in the regulation of a wide variety of processes including angiogenesis,extracellular matrix transformation,cancer cell proliferation,metastasis,immunosuppression,and resistance to chemotherapeutic and checkpoint blockade immunotherapies.Herein,we discuss immune regulation in macrophage polarization and signaling,mechanical stresses and modulation,metabolic signaling pathways,mitochondrial and transcriptional,and epigenetic regulation.Furthermore,we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage functions.Moreover,we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and tumorigenesis.Lastly,we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases. | Shanze Chen Abdullah F.U.H.Saeed Quan Liu Qiong Jiang Haizhao Xu Gary Guishan Xiao Lang Rao Yanhong Duo | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 2 |
| 2 | Multimodal MEMS vibration energy harvester with cascaded flexible and silicon beams for ultralow frequency response显示文摘Scavenged energy from ambient vibrations has become a promising energy supply for autonomous microsystems.However,restricted by device size,most MEMS vibration energy harvesters have much higher resonant frequencies than environmental vibrations,which reduces scavenged power and limits practical applicability.Herein,we propose a MEMS multimodal vibration energy harvester with specifically cascaded flexible PDMS and'zigzag'silicon beams to simultaneously lower the resonant frequency to the ultralow-frequency level and broaden the bandwidth.A two-stage architecture is designed,in which the primary subsystem consists of suspended PDMS beams characterized by a low Young's modulus,and the secondary system consists of zigzag silicon beams.We also propose a PDMS lift-off process to fabricate the suspended flexible beams and the compatible microfabrication method shows high yield and good repeatability.The fabricated MEMS energy harvester can operate at ultralow resonant frequencies of 3 and 23 Hz,with an NPD index of 1.73μW/cm^(3)/g^(2)@3 Hz.The factors underlying output power degradation in the low-frequency range and potential enhancement strategies are discussed.This work offers new insights into achieving MEMS-scale energy harvesting with ultralow frequency response. | Haizhao Feng Ling Bu Zhangshanhao Li Sixing Xu Bingmeng Hu Minghao Xu Siyao Jiang Xiaohong Wan | 2023 | Microsystems & Nanoengineering2023，9，2： | 0 |
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