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| 1 | Th22 cells are associated with hepatocellular carcinoma development and progression显示文摘Objective: IL-22-producing CD4+ T helper cells(Th22 cells) have been identified as major inducers of tissue inflammation and immune responses. Currently, no previous study explored the role of Th22 cells in the pathogenesis of hepatocellular carcinoma(HCC). The study aimed to determine the biological function of Th22 cells and its effector IL-22 in HCC patients.Methods: Forty-five HCC patients and 19 healthy controls were recruited and their peripheral blood was collected. The fresh HCC tissues, adjacent HCC tissues and ten normal liver tissues were also collected. Flow cytometry analysis was used to determine the frequencies of circulating Th22 cells and Th17 cells. Serum IL-22 levels were tested by enzyme-linked immunosorbent assay(ELISA). Immunohistochemical staining and real-time polymerase chain reaction(PCR) were used to detect IL-22 protein and mRNA in tissues specimens, respectively.Results: Circulating Th22 cells, Th17 cells and serum IL-22 levels were significantly elevated in HCC patients compared with those of healthy controls(P<0.001). Th22 cells were showed to be positively correlated with IL-22 in HCC patients(P<0.05), but not in healthy controls. No significant differences were found in HCC patients with HBeAg positivity or negativity in term of Th22 cells and serum IL-22 levels. The expression of IL-22 protein and mRNA was highest in HCC tissues, followed by adjacent HCC tissues and normal liver tissues. Furthermore, Th22 cells, serum IL-22 levels and IL-22 mRNA were elevated at stage III-IV compared with stage I-II of HCC(P<0.05).Conclusions: Elevation of circulating Th22 cells and IL-22 may be implicated in the pathogenesis of HCC, and potentially be cellular targets for therapeutic intervention. | Shanyu Qin Shijia Ma Xiaoli Huang Donghong Lu You Zhou Haixing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，2： | 25 |
| 2 | Multi-objective Optimisation Design of Water Distribution Systems:Comparison of Two Evolutionary Algorithms显示文摘In order to compare two advanced multi-objective evolutionary algorithms,a multi-objective water distribution problem is formulated in this paper.The multi-objective optimization has received more attention in the water distribution system design.On the one hand the cost of water distribution system including capital,operational,and maintenance cost is mostly concerned issue by the utilities all the time;on the other hand improving the performance of water distribution systems is of equivalent importance,which is often conflicting with the previous goal.Many performance metrics of water networks are developed in recent years,including total or maximum pressure deficit,resilience,inequity,probabilistic robustness,and risk measure.In this paper,a new resilience metric based on the energy analysis of water distribution systems is proposed.Two optimization objectives are comprised of capital cost and the new resilience index.A heuristic algorithm,speedconstrained multi-objective particle swarm optimization( SMPSO) extended on the basis of the multi-objective particle swarm algorithm,is introduced to compare with another state-of-the-art heuristic algorithm,NSGA-II.The solutions are evaluated by two metrics,namely spread and hypervolume.To illustrate the capability of SMPSO to efficiently identify good designs,two benchmark problems( two-loop network and Hanoi network) are employed.From several aspects the results demonstrate that SMPSO is a competitive and potential tool to tackle with the optimization problem of complex systems. | Haixing Liu Jing Lu Ming Zhao Yixing Yuan | 2016 | Journal of Harbin Institute of Technology(New Series)2016，23，3： | 3 |
| 3 | The elasto-damage theory of the components assembling model显示文摘The potential energy in materials is well approximated by pair functional which is composed of pair potentials and embedding energy. During calculating material potential energy, the orientational component and the volumetric component are derived respectively from pair potentials and embedding energy. The sum of energy of all these two kinds of components is the material potential. No matter how microstructures change, damage or fracture, at the most level, they are all the changing and breaking atomic bonds. As an abstract of atomic bonds, these components change their stiffness during damaging. Material constitutive equations have been formulated by means of assembling all components' response functions. This material model is called the component assembling model. Theoretical analysis and numerical computing indicate that the proposed model has the capacity of reproducing some results satisfactorily, with the advantages of great conceptual simplicity, physical explicitness, and intrinsic induced anisotropy, etc. | DENG ShouChun LIANG NaiGang LU HaiXing | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，1： | 2 |
| 4 | Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field显示文摘Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged cartilage.Hydrogel is widely used because it could provide rapid defect filling and proper structure support,and is biocompatible for cell aggregation and matrix deposition.Efforts have been made to seek suitable scaffolds for cartilage tissue engineering.Here Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing properties.Gelation time,swelling ratio,biodegradability and biocompatibility of the hydrogels were systematically characterized,and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage repair.Furthermore,the new hydrogel design introduces a pre-gel state before photo-crosslinking,where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid condition.This granted multiple administration routes to the hydrogels,which brings hydrogels the ability to adapt to complex clinical situations.Pulsed electromagnetic fields(PEMF)have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic potentials.PEMF treatment offers a better clinical outcome with fewer,if any,side effects,and wildly used in musculoskeletal tissue repair.Thereby we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue engineering.In this study,the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model,and the potential application of PEMF in cartilage tissue engineering were investigated.PEMF treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro,and facilitate chondrogenesis and cartilage repair in vivo.All of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment,this newly proposed tissue engineering strategy revealed superior clinical potential for cartilage defect treatment. | Yucong Li Linlong Li Ye Li Lu Feng Bin Wang Ming Wang Haixing Wang Meiling Zhu Yongkang Yang Erik IWaldorff Nianli Zhang Ingmar Viohl Sien Lin Liming Bian Wayne Yuk-Wai Lee Gang Li | 2023 | Bioactive Materials2023，，4： | 1 |
| 5 | O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair显示文摘Lacking self-repair abilities,injuries to articular cartilage can lead to cartilage degeneration and ultimately result in osteoarthritis.Tissue engineering based on functional bioactive scaffolds are emerging as promising approaches for articular cartilage regeneration and repair.Although the use of cell-laden scaffolds prior to implantation can regenerate and repair cartilage lesions to some extent,these approaches are still restricted by limited cell sources,excessive costs,risks of disease transmission and complex manufacturing practices.Acellular approaches through the recruitment of endogenous cells offer great promise for in situ articular cartilage regeneration.In this study,we propose an endogenous stem cell recruitment strategy for cartilage repair.Based on an injectable,adhesive and self-healable o-alg-THAM/gel hydrogel system as scaffolds and a biophysio-enhanced bioactive microspheres engineered based on hBMSCs secretion during chondrogenic differentiation as bioactive supplement,the as proposed functional material effectively and specifically recruit endogenous stem cells for cartilage repair,providing new insights into in situ articular cartilage regeneration. | Yucong Li Linlong Li Ming Wang Boguang Yang Baozhen Huang Shanshan Bai Xiaoting Zhang Nan Hou Haixing Wang Zhengmeng Yang Chong Tang Ye Li Wayne Yuk-Wai Lee Lu Feng Micky D.Tortorella Gang Li | 2023 | Bioactive Materials2023，，10： | 0 |
| 6 | Genomic dissection of gastrointestinal and lung neuroendocrine neoplasm显示文摘Objective:Neuroendocrine neoplasms(NENs)are relatively rare and heterogeneous malignancies with two major subtypes:low-grade neuroendocrine tumor(NET)and high-grade neuroendocrine carcinoma(NEC).Comprehensive molecular characterization of NENs is needed to refine our understanding of the biological underpinnings of different NEN subtypes and to predict disease progression more accurately.Methods:We performed whole-exome sequencing(WES)of NEN samples from 49 patients(25 NETs and 24 NECs)arising from the stomach,intestines or lung.Clinicopathologic features were assessed and associated with molecular events.Results:NENs generally harbor a low mutation burden,with TP53 being the top mutated gene found in 31%of patients.Consistent with other studies,p53 signaling pathway dysfunction is significantly enriched in NECs compared to NETs(P<0.01).Other than TP53,tissue type-specific mutation profiles of NENs were observed in our cohort compared to those reported in pancreatic NETs.Importantly,we observed significant genomic instability,with increased copy number alterations observed across the NEN genome,which was more profound in NECs and independently correlated with poor overall survival(OS)(P<0.001).NECs could be further stratified into two molecular subtypes based on OS(P<0.001)and the chromosomal instability score(CIS).Interestingly,we discovered that the gain of whole chromosome 5 occurred at the early stage of NEN development,followed by the loss of 5 q exclusively in NECs(P<0.001).Conclusions:These findings provide novel insights into the molecular characteristics of NENs and highlight the association of genomic stability with clinical outcomes. | Haixing Wang Li Sun Hua Bao Ao Wang Panpan Zhang Xue Wu Xiaoling Tong Xiaonan Wang Jie Luo Lin Shen Yang WShao Ming Lu | 2019 | Chinese Journal of Cancer Research2019，31，6： | 0 |
| 7 | Artificial intelligence empowering research on loneliness, depression and anxiety-Using Covid-19 as an opportunity显示文摘The COVID-19 pandemic has had a profound impact on public mental health,leading to a surge in loneliness,depression,and anxiety.And these public psychological issues increasingly become a factor affecting social order.As researchers explore ways to address these issues,artificial intelligence(AI)has emerged as a powerful tool for understanding and supporting mental health.In this paper,we provide a thorough literature review on the emotions(EMO)of loneliness,depression,and anxiety(EMO-LDA)before and during the COVID-19 pandemic.Additionally,we evaluate the application of AI in EMO-LDA research from 2018 to 2023(AI-LDA)using Latent Dirichlet Allocation(LDA)topic modeling.Our analysis reveals a significant increase in the proportion of literature on EMO-LDA and AI-LDA before and during the COVID-19 pandemic.We also observe changes in research hotspots and trends in both field.Moreover,our results suggest that the collaborative research of EMO-LDA and AI-LDA is a promising direction for future research.In conclusion,our review highlights the urgent need for effective interventions to address the mental health challenges posed by the COVID-19 pandemic.Our findings suggest that the integration of AI in EMO-LDA research has the potential to provide new insights and solutions to support individuals facing loneliness,depression,and anxiety.And we hope that our study will inspire further research in this vital and revelant domin. | Qijian Zheng Feng Liu Shuya Xu Jingyi Hu Haixing Lu Tingting Liu | 2023 | Journal of Safety Science and Resilience2023，4，4： | 0 |
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