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| 1 | The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer显示文摘Background:As a rate-limiting enzyme of glycolysis,pyruvate kinase muscle isozyme M2(PKM2)participates in tumor metabolism and growth.The regulatory network of PKM2 in cancer is complex and has not been fully studied in bladder cancer.The 5-methylcytidine(m5C)modification in PKM2 mRNA might participate in the pathogenesis of bladder cancer and need to be further clarified.This study aimed to investigate the biological function and regulatory mechanism of PKM2 in bladder cancer.Methods:The expression of PKM2 and Aly/REF export factor(ALYREF)was measured by Western blotting,qRT-PCR,and immunohistochemistry.The bioprocesses of bladder cancer cells were demonstrated by a series of experiments in vitro and in vivo.RNA immunoprecipitation,RNA-sequencing,and dualluciferase reporter assays were conducted to explore the potential regulatory mechanisms of PKM2 in bladder cancer.Results:In bladder cancer,we first demonstrated that ALYREF stabilized PKM2 mRNA and bound to its m5C sites in 3′-untranslated regions.Overexpression of ALYREF promoted bladder cancer cell proliferation by PKM2-mediated glycolysis.Furthermore,high expression of PKM2 and ALYREF predicted poor survival in bladder cancer patients.Finally,we found that hypoxia-inducible factor-1alpha(HIF-1α)indirectly up-regulated the expression of PKM2 by activating ALYREF in addition to activating its transcription directly.Conclusions:The m5C modification in PKM2 mRNA in the HIF-1α/ALYREF/PKM2 axis may promote the glucose metabolism of bladder cancer,providing a new promising therapeutic target for bladder cancer. | Jing-Zi Wang Wei Zhu Jie Han Xiao Yang Rui Zhou Hong-Cheng Lu Hao Yu Wen-Bo Yuan Peng-Chao Li Jun Tao Qiang Lu Ji-Fu Wei Haiwei Yang | 2021 | Cancer Communications2021，41，7： | 17 |
| 2 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 3 | Exosome-mediated metabolic reprogramming:the emerging role in tumor microenvironment remodeling and its influence on cancer progression显示文摘Metabolic reprogramming is reported to be one of the hallmarks of cancer,which is an adaptive mechanism by which fast-growing cancer cells adapt to their increasing energy demands.Recently,extracellular vesicles(EVs)known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment(TME).Meanwhile,the TME is a highly heterogeneous ecosystem incorporating cancer cells,fibroblasts,adipocytes,endothelial cells,mesenchymal stem cells,and extracellular matrix.Accumulated evidence indicates that exosomes may transfer biologically functional molecules to the recipient cells,which facilitate cancer progression,angiogenesis,metastasis,drug resistance,and immunosuppression by reprogramming the metabolism of cancer cells and their surrounding stromal cells.In this review,we present the role of exosomes in the TME and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming.In addition,we will also discuss the potential role of exosomes targeting metabolic process as biomarkers for tumor diagnosis and prognosis,and exosomes-mediated metabolic reprogramming as potential targets for cancer therapy.Furthermore,a better understanding of the link between exosomes and metabolic reprogramming,and their impact on cancer progression,would provide novel insights for cancer prevention and treatment in the future. | Enli Yang Xuan Wang Zhiyuan Gong Miao Yu Haiwei Wu Dongsheng Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 4 | Genotypic variation in phosphorus acquisition from sparingly soluble P sources is related to root morphology and root exudates in Brassica napus显示文摘Genotypic variations in the adaptive response to low-phosphorus(P) stress and P-uptake efficiency have been widely reported in many crops.We conducted a pot experiment to evaluate the P-acquisition ability of two rapeseed(Brassica napus) genotypes supplied with two sparingly soluble sources of P,Al-P and Fe-P.Then,the root morphology,proton concentrations,and carboxylate content were investigated in a solution experiment to examine the genotypic difference in P-acquisition efficiency.Both genotypes produced greater biomass and accumulated more P when supplied with Al-P than when supplied with Fe-P.The P-efficient genotype 102 showed a significantly greater ability to deplete sparingly soluble P from the rhizosphere soil because of its greater biomass and higher P uptake compared with those of the P-inefficient genotype 105.In the solution experiment,the P-efficient genotype under low-P conditions developed dominant root morphological traits,and it showed more intensive rhizosphere acidification because of greater H+ efflux,higher H+-ATPase activity,and greater exudation of carboxylates than the P-inefficient genotype.Thus,a combination of morphological and physiological mechanisms contributed to the genotypic variation in the utilization of different sparingly soluble P sources in B.napus. | ZHANG HaiWei HUANG Yu YE XiangSheng XU FangSen | 2011 | Science China(Life Sciences)2011，54，12： | 6 |
| 5 | Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages显示文摘发炎是到损害和感染的身体纸巾的回答。能禁止发炎的混合物被显示了有潜在的治疗学的临床的申请。Gambogenic 酸(GEA ) 有有势力 antitumor 和反煽动性的活动。此处, GEA 反煽动性的效果的分子的机制在刺激的 lipopolysaccharide (LPS ) 被调查巨噬细胞房间。结果证明有 GEA 的那个预告的处理能显著地禁止 interleukin (IL )-1, IL-1,肿瘤坏死因素 -- ,以在导致 LPS 的模型的一种剂量依赖者方式的 IFN- , IL-12b,和 IL-23a 生产。而且,这药显著地减少了氮的氧化物的版本(没有) ,并且损害了蛋白质水平可诱导没有 synthase 和 cyclooxygenase 2。发现也证明 GEA 的效果可能与原子 factor-B (NF-B ) 和表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 GEA 能由 attenuating 部分压制模仿 LPS 的煽动性的反应没有合成和 NF-B 和 MAPK 激活,建议它可以成为一个有势力为煽动性的疾病的处理的治疗学的代理人。 | Xianjun Yu Qun Zhao Haiwei Zhang Cunxian Fan Xixi Zhang Qun Xie Chengxian Xu Yongbo Liu Xiaoxia Wu Quanbin Han Haibing Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 6 | Acidity effects of Hβ zeolite on olefin alkylation of thiophenic sulfur in gasoline显示文摘thiophenic 硫过程的石蜡完化在模型汽油被执行,用有象催化剂的不同 Si/Al 2 比率的 Hβ 沸石。特别地,它为 thiophene 完化,二甲苯完化和 hexene oligomerization 的催化能力上的 Hβ 沸石的酸性质的影响被调查。结果证明 Hβ 沸石的酸味与 Si/Al 2 比率的减少被增加,但是它的催化能力总是没被增加。事实上,它在 66 的 Si/Al 2 比率到达了最大的催化能力,并且在溪流 2 h 上的 60 ° C, 1.5 MPa, WHSV 3.0 h −1 和时间的反应条件下面。在比率, thiophene 的变换,二甲苯,和 oligomerized, hexene 分别地是 96.6% , 2.7% 和 2.8% 。最佳的 Si/Al 2 比率为 Hβ 沸石的催化表演存在。由调查使用的 Hβ 沸石催化剂的焦炭免职,最佳的 Si/Al 2 比率被归因于 carbocation 激活能力和 Hβ 沸石催化剂的氢转变能力的联合效果,这被发现了。 | Zekai Zhang Dong Liu Xiangxue Zhu Haiwei Yu Shenglin Liu Longya Xu | 2008 | Journal of Natural Gas Chemistry2008，17，1： | 4 |
| 7 | Single amino acid substitution of VP1 N17D or VP2 H145Y confers acid-resistant phenotype of type Asia1 foot-and-mouth disease virus显示文摘Infection by foot-and-mouth disease virus(FMDV) is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. However, dissociation of the FMDV 146S particle in mildly acidic conditions renders inactivated foot-and-mouth disease(FMD) vaccines much less effective. Type Asia1 FMDV mutants with increased resistance to acid inactivation were selected to study the molecular basis of viral resistance to acid-induced disassembly and improve the acid stability of FMDV. Sequencing of capsid-coding regions revealed four amino acid replacements(VP1 N17D, VP2 H145Y, VP2 G192D, and VP3 K153E) in the viral population of the acid-selected 10th passage. We performed single or combined mutagenesis using a reverse genetic system, and our results provide direct experimental evidence that VP2 H145Y or VP1 N17D substitution confers an acid-resistant phenotype to type Asia1 FMDV. | Haiwei Wang Shanshan Song Jianxiong Zeng Guohui Zhou Decheng Yang Te Liang Li Yu | 2014 | Virologica Sinica2014，29，2： | 2 |
| 8 | Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection显示文摘COVID-19 caused by SARS-CoV-2 infection has caused substantial morbidity and mortality worldwide and paralyzed the international economy.Understanding the magnitude and duration of the antibody response to SARS-CoV-2 is important to achieve a balance between curbing the pandemic and minimizing adverse effects on society.1 Although the antibody response to SARS-CoV-2 within 9 months has been extensively studied,2,3,4,5,6 little is known about the magnitude and kinetics of antibody responses for over 9 months.Moreover,with limited observations over 9 months(n<100),2,7,8 several studies have produced inconsistent conclusions about antibody dynamics,suggesting different rates of antiviral antibody positivity at the last follow-up.2,7,8 These studies have been limited by a lack of measurement of neutralizing antibodies(NAbs),7 of inclusion of mild or asymptomatic cases,2,8 and of further exploration of potential predisposing factors for antibody dynamics.2,7 Considering the individual heterogeneity(such as disease severity)8 and time-dependent nature1 of the immune response,in-depth characterization of SARS-CoV-2 antibody kinetics across disease severity groups over a long period is urgently needed.Therefore,we repeatedly tested IgM,IgG,viral spike protein receptor-binding dom(anti-RBD)IgG,and NAb titers in COVID-19 patients during a follow-up period of up to 10 months and explored potential predisposing factors of antibody titers during follow-up. | Hao Wang Yu Yuan Mingzhong Xiao Li Chen Youyun Zhao Haiwei Zhang Pinpin Long Yana Zhou Xi Xu Yanshou Lei Bihao Wu Tingyue Diao Hao Cai Li Liu Zuoyu Shao Jingzhi Wang Yansen Bai Kai Wang Miao Peng Linlin Liu Shi Han Fanghua Mei Kun Cai Yake Lei An Pan Chaolong Wang Rui Gong Xiaodong Li Tangchun Wu | 2021 | Cellular & Molecular Immunology2021，18，7： | 1 |
| 9 | Insertion of type O-conserved neutralizing epitope into the foot-and-mouth disease virus type Asia1 VP1 G-H loop: effect on viral replication and neutralization phenotype显示文摘 | Haiwei Wang Mei Xue Decheng Yang Guohui Zhou Donglai Wu Li Yu | 2012 | Journal of General Virology (Pt )2012，，7： | 1 |
| 10 | Genotypic differences in phosphorus acquisition and the rhizosphere properties of Brassica napus in response to low phosphorus stress显示文摘 | Haiwei Zhang Yu Huang Xiangsheng Ye Lei Shi Fangsen Xu | 2009 | Plant and Soil (-)2009，，1： | 1 |
| 11 | RIPK3介导FADD缺陷小鼠胚胎发育中的程序性坏死及出生后的炎症反应显示文摘文章简介细胞程序性死亡在生物体发育、成体稳态及免疫防御中具有重要作用。RIPK3是近年发现介导细胞程序性坏死信号通路的关键调控蛋白,RIPK3的缺失能完全阻断细胞程序性坏死的发生。 | Qun Zhao XianJun Yu HaiWei Zhang YongBo Liu XiXi Zhang XiaoXia Wu Qun Xie Ming Li Hao Ying 章海兵 | 2018 | 科学新闻2018，0，4： | 0 |
| 12 | MLKL与FADD蛋白在抑制淋巴细胞增生以及激活炎症小体中的关键作用显示文摘细胞程序性死亡是生物体最重要的生命活动之一,对胚胎发育及形态发生、组织内环境稳定、机体的防御和免疫调节均起着关键作用。 | Xixi Zhang Cunxian Fan Haiwei Zhang Qun Zhao Yongbo Liu Chengxian Xu Qun Xie Xiaoxia Wu Xianjun Yu Jianke Zhang 章海兵 | 2017 | 科学新闻2017，19，4： | 0 |
| 13 | What is Steering the Direction of Capital Flows?显示文摘As a basic element of economic life,capital flow has its own running rules.Cross-border capital flows are affected by both external and internal factors.The external factors include policies and economic fundamentals of major overseas economies,global risk preference,etc.,while internal factors include domestic policies and economic fundamentals,institutional changes,etc. | WU Ge CAO Haiwei YU Tao GAO Tong | 2022 | China Forex2022，，2： | 0 |
| 14 | Microwave awakening the n-π^(*) electronic transition in highly crystalline polymeric carbon nitride nanosheets for photocatalytic hydrogen generation显示文摘The n-π^(*) electronic transition in polymeric carbon nitride(PCN)can remarkably harvest visible light,which thus potentially promotes the photocatalytic hydrogen H2 generation.However,awaking the n-π^(*) lectronic transition has proven to be a grand challenge.Herein,we reported on the awakening of n-π^(*) electronic transition by microwave thermolysis of urea pellet,which yielded the PCN with absorption edge of 600 nm,near 140 nm red-shift from 460 nm of pristine PCN.The n-π^(*) electronic transition endows PCN with an increased photocata lytic H_(2) generation,with a highest H_(2) rate of 61.7μmol h^(-1) under visible light exposure,which is near 6 times higher than that by using the PCN from the thermolysis of urea pellets in an electric furnace(10.6μmol h^(-1)).Furthermore,the n-π^(*) transition in PCN leads to the longest wavelength of 535 nm that can initiate H2 generation,remarkably longer than the absorption edge of pristine PCN(460 nm).This work manifests the advantages of microwave sintering route to awaken the n-π^(*) electronic transition in PCN for an increased photocata lytic performance. | Xiangang Lin Haiwei Du Daochuan Jiang Peng Zhang Zhiwu Yu Hong Bi Yupeng Yuan | 2022 | Journal of Energy Chemistry2022，31，2： | 0 |
| 15 | Multimodal 3D Convolutional Neural Networks for Classification of Brain Disease Using Structural MR and FDG-PET Images显示文摘The classification and identification of brain diseases with multimodal information have attracted increasing attention in the domain of computer-aided. Compared with traditional method which use single modal feature information, multiple modal information fusion can classify and diagnose brain diseases more comprehensively and accurately in patient subjects. Existing multimodal methods require manual extraction of features or additional personal information, which consumes a lot of manual work. Furthermore, the difference between different modal images along with different manual feature extraction make it difficult for models to learn the optimal solution. In this paper, we propose a multimodal 3D convolutional neural networks framework for classification of brain disease diagnosis using MR images data and PET images data of subjects. We demonstrate the performance of the proposed approach for classification of Alzheimer’s disease (AD) versus mild cognitive impairment (MCI) and normal controls (NC) on the Alzheimer’s Disease National Initiative (ADNI) data set of 3D structural MRI brain scans and FDG-PET images. Experimental results show that the performance of the proposed method for AD vs. NC, MCI vs. NC are 93.55% and 78.92% accuracy respectively. And the accuracy of the results of AD, MCI and NC 3-classification experiments is 68.86%. | Kun Han Haiwei Pan Ruiqi Gao Jieyao Yu Bin Yang | 2019 | 国际计算机前沿大会会议论文集2019，，1： | 0 |
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