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您的检索式：作者名="Haiting Pan"
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| 1 | General and Modular Access to Enantioenriched α-Trifluoromethyl Ketones via Nickel-Catalyzed Reductive Trifluoroalkylation显示文摘The development of new catalytic enantioselective access to stereogenic CF_(3)-containingmolecules is of great interest for expediting the discovery of lead compounds that remain challenging.Specifically,enantioselective synthesis of valuable ketones featuring stereogenicα-CF_(3) has rarely been reported.We devise a general and modular approach to facilely access enantioenrichedα-CF_(3) ketones via nickel-catalyzed reductive cross-coupling of readily available acid chlorides and racemicα-CF_(3) alkyl bromides in an enantioconvergent fashion under mild conditions.This protocol features neighboring directing group-free,high chemoselectivity,excellent functional group tolerance,facile scale-up,and notable amenability to straightforward downstream elaboration toward pharmaceutically useful enantioenrichedβ-trifluoromethylated secondary and tertiary alcohols,thus constituting a reliable,direct,practical,and efficient synthetic alternative to furnish enantiopureα-CF_(3) carbonyls.Interestingly,an appropriate choice of the phosphine ligand as coligand plays an important role in high efficiency and asymmetric induction.Mechanistic studies suggest a radical chain pathway. | Dengkai Lin Yongzhi Chen Zhan Dong Pan Pei Haiting Ji Lanzhu Tai Liang-An Chen | 2023 | CCS Chemistry2023，5，6： | 0 |
| 2 | A near-infrared fluorescent probe for fast and precise imaging of senescent cells and ovarian cancer cells via trackingβ-galactosidase显示文摘Aging-related diseases are gradually becoming a major problem with the rapid development of aged population in human society.Although many fluorescent probes have been employed to diagnosis senescence via imaging senescence-associatedβ-galactosidase(SA-β-Gal),which is proved to be closely associated with senescent cells,the similar catalytic effectiveness of enzymatic reaction of ovarian cancer-associatedβ-Gal(OA-β-Gal)will interfere with imaging accuracy.Herein,a near-infrared(NIR)hemicyanine based fluorescent probe HCyXA-βGal was designed for light-up imaging of live cells containingβ-Gal.With the organelle-targeting morpholinyl and positive charge moieties,HCyxA-βGal was successfully applicated to image the difference of enzymatic location in senescent cells and ovarian cancer cells.Furthermore,inspired by the fast response performance,fast and precise imaging of the two cell lines was realized via covering another dimension of fluorescence signal:time-dependent intensity. | Haiting Pan Xianzhi Chai Junji Zhang | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
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