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| 1 | A thermostability perspective on enhancing physicochemical and cytological characteristics of octacalcium phosphate by doping iron and strontium显示文摘Investigation of thermostability will lead the groundbreaking of unraveling the mechanism of influence of ion-doping on the properties of calcium phosphates.In this work,octacalcium phosphate(OCP),a metastable precursor of biological apatite,was used as a stability model for doping ions(Fe^(3+)and Sr^(2+))with different ionic charges and radii.After treated under hot air at different temperatures(110-200◦C),the phase,morphology,structure,physicochemical properties,protein affinity,ions release,and cytological responses of the ion-doped OCPs were investigated comparatively.The results showed that the collapse of OCP crystals gradually occurred,accompanying with the dehydration of hydrated layers and the disintegration of plate-like crystals as the temperature increased.The collapsed crystals still retained the typical properties of OCP and the potential of conversion into hydroxyapatite.Compared to the undoped OCP,Fe-OCP,and Sr-OCP had lower and higher thermostability respectively,leading to different material surface properties and ions release.The adjusted thermostability of Fe-OCP and Sr-OCP significantly enhanced the adsorption of proteins(BSA and LSZ)and the cytological behavior(adhesion,spreading,proliferation,and osteogenic differentiation)of bone marrow mesenchymal stem cells to a varying extent under the synergistic effects of corresponding surface characteristics and early active ions release.This work paves the way for understanding the modification mechanism of calcium phosphates utilizing ion doping strategy and developing bioactive OCP-based materials for tissue repair. | Haishan Shi Xiaoling Ye Jing Zhang Tingting Wu Tao Yu Changren Zhou Jiandong Ye | 2021 | Bioactive Materials2021，6，5： | 3 |
| 2 | ^(99m)Tc-3P_4 -RGD_2 radiotracers for SPECT/CT of esophageal tumor显示文摘In recent years,several RGD(Arg-Gly-Asp)-based radiotracers have already been successfully tested in human for the visualization of integrin αvβ3,demonstrating its feasibility in tumor diagnosis.In this paper,we evaluated the 99mTc-3P4-RGD2 single photon emission computed tomography/computerized tomography(SPECT/CT)in patients suffering from space occupying disease of esophagus.40 patients(34 males and 6 female;mean age: 58.3 years) with a suspected space occupying lesion of esophagus were included,thus finally obtaining their definite pathologic diagnosis(malignant,n=32;benign,n=8).All patients underwent endoscopic,barium esophagography and SPECT/CT imaging preoperatively.The chest SPECT was performed at 4 h after administration of99mTc-3P4-RGD2 with a dose of 939±118 MBq.The diagnosis precision,sensitivity and specificity among these methods were compared.The relationship between radioactive uptake and clinical pathological stage of esophageal carcinoma was discussed by calculating the tumor to normal esophagus(T/N).Meanwhile,the integrin αvβ3 expression was assessed immunohistochemically in postoperative esophageal tissues.31 patients were diagnosed as esophageal carcinoma;and 1,leiomyosarcoma;and 6.leimyoma;and 2,esophageal tuberculosis.The accuracy,sensitivity and specificity of barium esophagography,endoscopic and SPECT/CT imaging are 92.5/93.8/87.5%,97.5/96.9/100%,and 90/90.6/87.5%,respectively.Abnormal accumulation of radiotracer in 29 malignant lesions is observed.The SPECT/CT imaging displayed the region of radioactive uptake and lesions matched extremely with the T/N ratio from 1.31 to 2.79(mean 2.04).A case with pulmonary metastases and a case with mediastinal lymph node metastases were found which were missed by barium esophagography and endoscopic.The99mTc-3P4-RGD2 uptake of the esophageal carcinoma masses had no relevance to the tumor pathologic classification(P>0.05).There was a significant positive correlation between T/N ratio and positive cell percentage of integrin αvβ3(r=0.976),demonstrating the certain clinical potential in the diagnosis of esophageal carcinoma. | GAO Shi MA Qingjie WEN Qiang JIA Bing LIU Zhaofei CHEN Zuowei ZHANG Haishan LI Dandan | 2013 | Nuclear Science and Techniques2013，24，4： | 3 |
| 3 | Improvement of Soil Moisture Simulation in Eurasia by the Beijing Climate Center Climate System Model from CMIP5 to CMIP6显示文摘This study provides a comprehensive evaluation of historical surface soil moisture simulation(1979-2012)over Eurasia at annual and seasonal time scales between two medium-resolution versions of the Beijing Climate Center Climate System Model(BCC-CSM)—one that is currently participating in phase 6 of the Coupled Model Intercomparison Project(CMIP6),i.e.,BCC-CSM2-MR,and the other,BCC-CSM1.1m,which participated in CMIP5.We show that BCC-CSM2-MR is more skillful in reproducing the climate mean states and standard deviations of soil moisture,with pattern correlations increased and biases reduced significantly.BCC-CSM2-MR performs better in capturing the first two primary patterns of soil moisture anomalies,where the period of the corresponding time series is closer to that of reference data.Comparisons show that BCC-CSM2-MR performs at a high level among multiple models of CMIP6 in terms of centered pattern correlation and“amplitude of variation”(relative standard deviation).In general,the centered pattern correlation of BCC-CSM2-MR,ranging from 0.61 to 0.87,is higher than the multi-model mean of CMIP6,and the relative standard deviation is 0.75,which surmounts the overestimations in most of the CMIP6 models.Due to the vital role played by precipitation in land-atmosphere interaction,possible causes of the improvement of soil moisture simulation are further related to precipitation in BCC-CSM2-MR.The results indicate that a better description of the relationship between soil moisture and precipitation and a better reproduction of the climate mean precipitation by the model may result in the improved performance of soil moisture simulation. | Yinghan SANG Hong-Li REN Xueli SHI Xiaofeng XU Haishan CHEN | 2021 | Advances in Atmospheric Sciences2021，38，2： | 2 |
| 4 | Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy显示文摘Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inflammation and result in drug toxicity.A cluster-like mesoporous silica/arctigenin/CAQK composite(MSN-FC@ARCG)drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord.In this nanosystem,mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites.The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier.Arctigenin,a Chinese herbal medicine,was loaded into the nanosystem to reduce inflammation.The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site.Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage,especially reducing the expression of interleukin-17(IL-17) and IL-17-related inflammatory factors,inhibiting the activation of astrocytes,thus protecting neurons and accelerating the recovery of SCI.Our study demonstrated that this novel,silica-based drug delivery system has promising potential for clinical application in SCI therapy. | Guodong Sun Shenghui Zeng Xu Liu Haishan Shi Renwen Zhang Baocheng Wang Changren Zhou Tao Yu | 2019 | Nano-Micro Letters2019，11，2： | 1 |
| 5 | All-Dielectric Electrooptic Sensor Based on a Polymer Microresonator Coupled Side-Polished Optical Fiber显示文摘 | Haishan Sun A Pyajt Jingdong Luo Zhengwei Shi S.Hau A.K.-Y.Jen L.R.Dalton A Chert | | 0，，04： | 1 |
| 6 | A pilot study on ^(99m)Tc-3PRGD2 scintigraphy in diagnosis of brain glioma显示文摘The 99mTc-3PRGD2 targeted SPECT/CT scanning was of significance in detecting differentiated glioma.In this work,the diagnostic value of 99mTc-3PRGD2 scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed consent.The patients first accepted X-ray imaging to localize the detecting regions before administrating with 99mTc-3PRGD2 at a mean radioactivity of 849±115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT imaging.Tumor samples for detectingαvβ3 were collected by surgical operations two weeks after the scintigraphy.The results of CT and SPECT scanning were merged and compared.The correlation between tumor occupation(T/N ratio) andαvβ3 expression level were analyzed.The T/N ratios in brain glioma were proportionally correlated to av(33 positive cell percentage(R2=0.9253,p<0.05).This study primarily evaluated the clinical application of 99mTc-3PRGD2 SPECT scintigraphy on brain glioma.The more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials. | GAO Shi MA Qingjie CUI Qu LIU Lin ZHOU Xueyan JIA Bing CHEN Zuowei ZHANG Haishan | 2013 | Nuclear Science and Techniques2013，24，2： | 1 |
| 7 | Patterns of species diversity and its determinants in a temperate deciduous broad-leaved forest显示文摘Biodiversity conservation has long been a subject of extreme interest to community ecologists,with a particular focus on exploring the underlying causes of species diversity based on niche and neutral theories.This study aims to identify the potential determinants of species diversity in a deciduous broad-leaved forest in the transitional region from subtropical to temperate climate in China.We collected woody plant data and environmental variables in a fully mapped 25-ha permanent forest plot,partitioned the beta-diversity into local contributions(LCBD)and species contributions(SCBD),and then applied multivariate linear regression analysis to test the effects of biotic and abiotic factors on alpha-diversity,LCBD,and SCBD.We used variation partitioning in combination with environmental variables and spatial distance to determine the contribution of environment-related variations versus spatial variations.Our results showed that the indices of alpha-diversity(i.e.,species abundance and richness)were positively correlated with soil available phosphorus(P)and negatively with slope.For the betadiversity,environment and space together explained nearly half of the variations in community composition.Approximately 60%of the variation of LCBD in the understory layer,40%in the substory layer,and 29%in the canopy layer were jointly explained by topographic,soil and biological variables,with biotic factors playing a dominant role in determining the beta-diversity.Species abundance accounted for a large proportion of the variations in SCBD in each vertical stratum,and niche position(NP)was the ecological trait that significantly affected the variations in SCBD in the substory and canopy layers.Our findings help to gain better understanding on how species diversity in forest ecosystem responds to environmental conditions and how it is influenced by biotic factors and ecological traits of species. | Rui He Man Hu Hang Shi Quan Zhou Xiao Shu Kerong Zhang Quanfa Zhang Haishan Dang | 2022 | Forest Ecosystems2022，9，5： | 0 |
| 8 | 基于CWRF的中国近海热带气旋集合模拟及其对物理参数化方案的敏感性研究显示文摘为评估CWRF模式的降尺度能力和其热带气旋模拟对物理参数化方案的敏感性,本文利用ERI再分析资料驱动CWRF在30km网格上对1982-2016年中国近海热带气旋开展了一次集合模拟.结果表明:CWRF与ERI均能模拟出热带气旋的季节变化和年际变化形势且均存在低估,但相较ERI,CWRF的降尺度技术和集合模拟可以再现更多的热带气旋,显著减少低估.年际变化结果提升最为明显,它对积云方案最为敏感,其次是边界层,陆面和辐射方案,对云和微物理方案较弱.该研究为应用CWRF理解和预报热带气旋提供了参考. | Wenru Shi Haishan Chen Xin-Zhong Liang | 2021 | Atmospheric and Oceanic Science Letters2021，14，1： | 0 |
| 9 | Habitat heterogeneity and biotic interactions mediate climate influences on seedling survival in a temperate forest显示文摘Seedling stage has long been recognized as the bottleneck of forest regeneration,and the biotic and abiotic processes that dominate at seedling stage largely affect the dynamics of forest.Seedlings might be particularly vulnerable to climate stress,so elucidating the role of interannual climate variation in fostering community dynamics is crucial to understanding the response of forest to climate change.Using seedling survival data of 69 woody species collected for five consecutive years from a 25-ha permanent plot in a temperate deciduous forest,we identified the effects of biotic interactions and habitat factors on seedling survival,and examined how those effects changed over time.We found that interannual climate variations,followed by biotic interactions and habitat conditions,were the most significant predictors of seedling survival.Understory light showed a positive impact on seedling mortality,and seedling survival responded differently to soil and air temperature.Effects of conspecific neighbor density were significantly strengthened with the increase of maximum air temperature and vapor pressure deficits in the growing season,but were weakened by increased maximum soil temperature and precipitation in the non-growing season.Surprisingly,seedling survival was strongly correlated with interannual climate variability at all life stages,and the strength of the correlation increased with seedling age.In addition,the importance of biotic and abiotic factors on seedling survival differed significantly among species-trait groups.Thus,the neighborhood-mediated effects on mortality might be significantly contributing or even inverting the direct effects of varying abiotic conditions on seedling survival,and density-dependent effects could not be the only important factor influencing seedling survival at an early stage. | Haikun Liu Hang Shi Quan Zhou Man Hu Xiao Shu Kerong Zhang Quanfa Zhang Haishan Dang | 2023 | Forest Ecosystems2023，10，5： | 0 |
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