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| 1 | Baicalin and rutin are major constituents in Shuanghuanglian injection involving anaphylactoid reaction显示文摘OBJECTIVE: To identify the constituents in Shuanghuanglian injection(SHLI) that correlate with anaphylactoid reaction.METHODS: Chemical fingerprints of 10 batches SHLI samples were determined by High Performance Liquid Chromatography(HPLC), and further investigated by similarity analysis. Combined with optical microscopy, both anaphylactoid experiments and confirmatory assay were displayed in Rat basophil leukemia cells(RBL-2H3) to obtain the histamine release inducing by SHLI. The content of histamine was tested by Enzyme-Linked Immuno Sorbent As-say method. Partial least squares regression(PLSR)method and HPLC-DAD-ESI-MSntechnology were conducted to analyze constituents in SHLI involving anaphylactoid reaction.RESULTS: The results of spectrum and effect relationships showed that the eight constituents were positively correlated with anaphylactoid reaction.Among which, nearly 90% of them were identified as baicalin and rutin with PLSR and HPLC-DAD-ESI-MSn. This result was in accordance with confirmatory assay on RBL-2H3 cells.CONCLUSION: Baicalin and rutin from SHLI were the main constituents involving anaphylactoid reaction. | Zhang Qi Cai Chengke Li Jian Wang Penglong Si Yinchu Ding Nan Gao Jing Zhang Yanqiu Ma Zhiqiang Lei Haimin Li Qiang | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 6 |
| 2 | Geniposide, the component of the Chinese herbal formula Tongluojiunao, protects amyloid-β peptide(1–42)-mediated death of hippocampal neurons via the non-classical estrogen signaling pathway显示文摘Tongluojiunao(TLJN) is an herbal medicine consisting of two main components, geniposide and ginsenoside Rg1. TLJN has been shown to protect primary cultured hippocampal neurons. However, its mechanism of action remains unclear. In the present study, primary cultured hippocampal neurons treated with Aβ1–42(10 μmol/L) significantly increased the release of lactate dehydrogenase, which was markedly reduced by TLJN(2 μL/mL), specifically by the component geniposide(26 μmol/L), but not ginsenoside Rg1(2.5 μmol/L). The estrogen receptor inhibitor, ICI182780(1 μmol/L), did not block TLJN- or geniposide-mediated decrease of lactate dehydrogenase under Aβ1–42-exposed conditions. However, the phosphatidyl inositol 3-kinase or mitogen-activated protein kinase pathway inhibitor, LY294002(50 μmol/L) or U0126(10 μmol/L), respectively blo cked the decrease of lactate dehydrogenase mediated by TLJN or geniposide. Therefore, these results suggest that the non-classical estrogen pathway(i.e., phosphatidyl inositol 3-kinase or mitogen-activated protein kinase) is involved in the neuroprotective effect of TLJN, specifically its component, geniposide, against Aβ1–42-mediated cell death in primary cultured hippocampal neurons. | Jiao Li Feng Wang Haimin Ding Chunyan Jin Jinyan Chen Yanan Zhao Xiaojing Li Wenju Chen Ping Sun Yan Tan Qi Zhang Xu Wang Angran Fan Qian Hua | 2014 | Neural Regeneration Research2014，9，5： | 3 |
| 3 | Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans显示文摘在哺乳动物,线粒体和它的 DNA (mtDNA ) 的继承严格地是母亲的,尽管一个精子能在授精期间把多达 100 功能的线粒体注入卵母细胞。为父亲的线粒体的消除负责的机制仍然保持大部分未知。我们这里报导这个父亲的 mitochondrial 消除过程在 Caenorhabditis elegans 被保存,并且 lysosomal 小径活跃地参予这个过程。分子并且细胞生物分析显示在野类型的动物,父亲的线粒体和 mtDNA 在授精以后在二个小时以内被破坏。在有损害 lysosomes 的动物,父亲的线粒体坚持直到晚胚胎的阶段。因此, lysosomal 小径在在授精期间介绍进卵母细胞的降级的父亲的线粒体起一个重要作用。我们的学习显示那 C。elegans 是为理解这保存了为动物开发和复制批评的生物过程并且把的一个优秀动物模型。 | Qinghua Zhou Haimin Li Ding Xue | 2011 | Cell Research2011，21，12： | 3 |
| 4 | The influence of forming processes on the distribution and morphologies of TiC in Al-Ti-C master alloys显示文摘 | Ding Haimin Liu Xiangfa Yu Line | 2007 | Scripta Materialia2007，57，： | 1 |
| 5 | A modified ge- netic algorithm (GA) for optimization of process process planning 显示文摘 | Wang Jinfeng Du Biqiang Ding Haimin | 2011 | Journal of Computers2011，6，3： | 1 |
| 6 | A Super-robust Armoured Superhydrophobic Surface with Excellent Anti-icing Ability显示文摘It has been proved that the construction of interconnected armour on superhydrophobic surface could significantly enhance the mechanical robustness.Here,a new kind of armour with frame/protrusion hybrid structure was achieved by nanosecond laser technology.Then,this armoured superhydrophobic surface demonstrated excellent durability,which could withstand linear abrasion(~3 N press)800 cycles,water jet test(1.0 MPa pressure)40 times and 100℃treatment 18 days.Particularly,the armoured superhydrophobic sample shows outstanding anti-icing ability,which can speed up the supercooled water dropping(no adhesion within 2 h),increase the freezing delay time by~3 times and maintain low adhesion force(less than 35 kPa)after 30 icing/de-icing cycles.Further finite element analysis and theoretical modeling proved that the developed frame/protuberance hybrid structure could effectively enhance the durability.The relatively low surface accuracy in this study can significantly reduce processing cost,which provides a bright future for the practical application of armour superhydrophobic materials. | Peng Wang Hui Zhao Boyuan Zheng Ximei Guan Bin Sun Yongli Liao Ying Yue Wei Duan Haimin Ding | 2023 | Journal of Bionic Engineering2023，20，5： | 1 |
| 7 | The influence of forming processes on the distribution and morphologies of TiC in Al-Ti-C master alloys 显示文摘 | Ding Haimin Liu Xiangfa Yu Lina | 2007 | Scr Mater2007，57，7： | 1 |
| 8 | Grain refinement of AZ31 magnesium alloy by new Al-Ti-C master alloys显示文摘 | Han Guang Liu Xiangfa Ding Haimin | 2009 | Trans Nonferrous Metals Soc China2009，19，6： | 1 |
| 9 | Effect of potassium on as-cast microstructure of a hypereutectic high chromium cast iron显示文摘The present work mainly evaluates the effect of potassium(K) on as-cast microstructure of a hypereutectic high chromium cast iron by means of a field emission scanning electron microscope(FESEM) and an X-ray diffractometer using CuKα radiation with a 2θ range of 30-130°.Results showed that,with the addition of K-containing modifier,the large lath-like and/or rod-like primary M7C3 carbides can be modified to the hexagonal prisms,and the eutectic carbides can also be refined.In addition,the carbides are distributed much more homogeneously in the matrix.The modification effect of K is due to its aggregation at the liquid-solid interface and the adsorption on the relatively fast growing planes during the solidification,which influence the growth rates of different crystal planes and lead to the modification of the carbides. | Liu Qing Yang Hua Ding Haimin Zhang Tian | 2011 | China Foundry2011，8，2： | 1 |
| 10 | Different elements-induced destabilisa- tion of TiC and its application on the grain refinement of Mg-A1 alloys显示文摘 | Ding Haimin Li Hui | 2009 | J Alloys Compd2009，485，： | 1 |
| 11 | Grain refinement of AZ31 magnesium alloy by new A1-Ti-C master alloys 显示文摘 | Han Guang Liu Xiangfa Ding Haimin | 2009 | Trans Nonferrous Metals Soc China2009，19，： | 1 |
| 12 | A modified genetic algorithm (GA) for optimization of processplanning 显示文摘 | Wang Jinfeng Du Biqiang Ding Haimin | 2011 | Journal of Computers2011，6，3： | 1 |
| 13 | Influence of graphite on concentration of carbon vacancies in ball-milled TiC_x显示文摘In this work, the influence of graphite on the ball-milled TiCx was studied. The results show that the lattice parameter of TiCx is increased when TiCx particles are ball-milled with graphite, which indicates a decrease in the concentration of carbon vacancies in the TiCx. It is considered that this decrease in the concentration of carbon vacancies results from the diffusion of carbon atoms from graphite into the TiCx. When the TiCx is ball-milled with more graphite, the effectiveness of the ball-milling is better, and the diffusion process of carbon becomes much easier. Furthermore, besides diffusion into the TiCx, some graphite has transformed into amorphous carbon after the ball-milling. | Ding Haimin Fan Xiaoliang Chu Kalyu Liu Xiangfa Nie Jinfeng | 2011 | China Foundry2011，8，4： | 0 |
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