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| 1 | Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health显示文摘Gut microbes comprise a high density, biologically active community that lies at the interface of an animal with its nutritional environment. Consequently their activity profoundly influences many aspects of the physiology and metabolism of the host animal. A range of microbial structural components and metabolites directly interact with host intestinal cells and tissues to influence nutrient uptake and epithelial health. Endocrine, neuronal and lymphoid cells in the gut also integrate signals from these microbial factors to influence systemic responses. Dysregulation of these host-microbe interactions is now recognised as a major risk factor in the development of metabolic dysfunction. This is a two-way process and understanding the factors that tip host-microbiome homeostasis over to dysbiosis requires greater appreciation of the host feedbacks that contribute to regulation of microbial community composition. To date, numerous studies have employed taxonomic profiling approaches to explore the links between microbial composition and host outcomes(especially obesity and its comorbidities), but inconsistent host-microbe associations have been reported. Available data indicates multiple factors have contributed to discrepancies between studies. These include the high level of functional redundancy in host-microbiome interactions combined with individual variation in microbiome composition; differences in study design, diet composition and host system between studies; and inherent limitations to the resolution of r RNA-based community profiling. Accounting for these factors allows for recognition of the common microbial and host factors driving community composition and development of dysbiosis on high fat diets. New therapeutic intervention options are now emerging. | Connie WY Ha Yan Y Lam Andrew J Holmes | 2014 | World Journal of Gastroenterology2014，20，44： | 4 |
| 2 | Assessing phylogenetic relationships of Lycium samples using RAPD and entropy theory显示文摘瞄准:在 Lycium 样品的相关种类之中评估种系发生的关系。方法:随机放大了采指纹的多态的 DNA (RAPD ) , lab-on-a-chip 电气泳动技术被用来分析 Lycium 种类的特征。七种和 Lycium 的 3 个变化被学习。基于从 11 份教材获得的 RAPD 指纹数据,我们建议了一个新索引,叫的 dispersivity,使用的熵理论和设计描绘 DNA 指纹的差异的方法。结果:用建议 dispersivity,教材被排序, 7 种类的 dendrograms 和 Lycium 的 3 个变化被合并教材信息综合地构造。结论:在 Lycium 样品之中的种系发生的关系基于从 11 份教材产生的 RAPD 指纹数据综合地被构造。 | Xiao-lin YIN Kai-tai FANG Yi-zeng LIANG Ricky NS WONG Amber WY HA | 2005 | Acta Pharmacologica Sinica2005，26，10： | 2 |
| 3 | Involvement of proeuxanthone-induced neurite differentiation of neuroblastoma 显示文摘 | Ha WY Wu PK Kok TW tein kinase C and E2F-5 in | 2006 | Int J Biochem Cell Biol2006，38，8： | 1 |
| 4 | A high-throughput detection method for hepatitis B virus mutations in the Chinese population 显示文摘 | Lau CC Ha WY Yue PY | 2008 | Hong Kong Med J2008，14，5： | 1 |
| 5 | Effect of sinomenine on gene expres- sion of the IL - 1 beta - activated human synovial sawoma 显示文摘 | Li XJ Yue PY Ha WY | 2006 | Life Sci2006，79，7： | 1 |
| 6 | Effects of combined exercise training on body composition and metabolic syndrome factors显示文摘 | Ha CH So WY | 2012 | l- ran J Public Health2012，41，8： | 1 |
| 7 | Authentication of Panax ginseng and Panax quinquefolius using amplified fragment length polymorphism (AFLP) and directed amplification of minisatellite region DNA (DAMD)显示文摘 | Ha WY Shaw PC Liu J | 2002 | J Agric Food Chem2002，50，： | 1 |
| 8 | The effect of hand hygiene compliance on hospital-acquired infections in an ICU setting in a Kuwaiti teaching hospital 显示文摘 | Salama MF Jamal WY Mousa HA | 2013 | J Infect Public Health2013，6，1： | 1 |
| 9 | Anti - inflammatory activity of CML- 1: an herbal formulation 显示文摘 | Eum HA Lee WY Kim SH | 2005 | Am J Chin Med2005，33，1： | 1 |
| 10 | Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS显示文摘 | Wang WY Ha CHH Jhun BS | | 0，，14： | 1 |
| 11 | Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction 显示文摘 | Chan K Chul SH Ha WY | 2004 | Life Sciences2004，75，： | 1 |
| 12 | The effect of hand hygiene compliance on hospital-acquired infections in an ICU setting in a Kuwaiti teaching hospital 显示文摘 | Salama MF Jamal WY Mousa HA | 2013 | J Infect Public Health2013，6，1： | 1 |
| 13 | Warming up the cold re- ception at TRPM8 function显示文摘 | Cheung WY Ha NR Suen MW | 2007 | Neurosci2007，27，： | 1 |
| 14 | Protective effects of Danshensu from the aqueous extract of Salvia mihiorrhiza (Danshen) against homoeysteine-induced endothelial dysfunction 显示文摘 | Chan K Chui SH Ha WY | 2004 | Life Sciences2004，75，： | 1 |
| 15 | Authentication of Panax ginseng and Panax quinquefolius using amplified fragment length polymorphism (AFLP) and directed amplification of minisatellite region DNA (DAMD)显示文摘 | Ha WY Shaw PC Liu J | 2002 | J Agric Food Chem2002，50，： | 1 |
| 16 | Endoscopic incision of a septum in a case of spontaneous intramural dissection of the esophagus显示文摘 | Ha SS Tak WY | 2002 | J Clin Gastroenterol2002，35，5： | 1 |
| 17 | Application of sequence characterized amplified region (SCAR) analysis to authenticate Panax species and their adulterants显示文摘 | Wang J Ha WY Ngan FN | 2001 | Planta Med2001，67，： | 1 |
| 18 | Authentication of Panax ginseng and Panax quinquefolius using amplified fragment length polymorphism (AFLP) and directed amplification of minisatellite region DNA (DAMD)显示文摘 | Ha WY Shaw PC | 2002 | J Agric Food Chem2002，50，7： | 1 |
| 19 | A high-throughput detection method for hepatitis B virus mutations in the Chinese popula- tion显示文摘 | Jau CC Ha WY Yue PY | 2008 | Hong Kong J2008，14，5： | 1 |
| 20 | Effect of sinomenine on gene expression of the IL-1β-activated human synovial sarcoma显示文摘 | Li XJ Yue PY Ha WY | 2006 | Life Scien2006，79，7： | 1 |
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