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| 1 | 禽流感病毒血凝素疫苗在转基因马铃薯中的表达显示文摘利用转基因马铃薯表达禽流感病毒血凝素疫苗。将含有禽流感病毒血凝素序列的表达载体导入农杆菌 ,再感染马铃薯的幼茎外植体。转化植株的再生及温室栽培。Westernblot分析表明 ,83%的转化植株在其块茎组织中表达了重组血凝素 ,表达量占总蛋白量的 0 0 3%~ 0 0 4 % 。 | 宋长征 Hugh S Mason | 2001 | 生物技术2001，11，5： | 25 |
| 2 | Changing face of hepatic encephalopathy:Role of inflammation and oxidative stress显示文摘The face of hepatic encephalopathy(HE) is changing.This review explores how this neurocognitive disorder,which is associated with both acute and chronic liver injury,has grown to become a dynamic syndrome that spans a spectrum of neuropsychological impairment,from normal performance to coma.The central role of ammonia in the pathogenesis of HE remains incontrovertible.However,over the past 10 years,the HE community has begun to characterise the key roles of inflammation,infection,and oxidative/nitrosative stress in modulating the pathophysiological effects of ammonia on the astrocyte.This review explores the current thoughts and evidence base in this area and discusses the potential role of existing and novel therapies that might abrogate the oxidative and nitrosative stresses inflicted on the brain in patients with,or at risk of developing,HE. | Amit S Seyan Robin D Hughes Debbie L Shawcross | 2010 | World Journal of Gastroenterology2010，16，27： | 23 |
| 3 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 4 | 饮水微量元素与老年人群认知能力关系研究显示文摘在中国山东与河南两省农村研究了饮水中微量元素与老年人群认知能力 (CognitiveFunction)之间的关系。采用中国国标方法分析了饮水中氟、钙、硒、铝、铁、锌、镉、铅、砷微量元素和pH值 ;用老年性痴呆症 (Dementia)调查表 ,进行了≥ 6 5岁老年暴露人群认知能力的测定。调整年龄、性别和文化水平后 ,对微量元素与老年认知能力之间的关系进行直线模型、二次方模型和联合作用模型的统计分析 ,评价饮水中每种微量元素浓度对老年认知能力的影响。结果表明 ,单因素分析时发现几种微量元素对老年认知能力有明显作用。然而 ,在调整其它元素水平后 ,其中一些元素的作用消失。饮水中钙浓度对老年认知能力呈现一作用曲线 ,即随着饮水钙水平升高而认知能力增加 ;到某一点高峰后 ,又随钙水平增加而认知能力降低。而锌与镉之间存在一种相互作用 ,即在低饮水镉水平时 ,锌浓度与认知能力呈正相关 ,但在高饮水镉水平时 。 | 梁超轲 吉荣娣 曹静祥 姜玉亭 余波 马凤 吴云鹏 应波 张妍 孙淑庄 Li Yiming Christine L Emsley Gao Sujuan Kathleen S Hall Hugh C Hendrie | 2003 | 卫生研究2003，32，5： | 12 |
| 5 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 6 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 7 | 心脏外科术后肺部并发症危险因素分析显示文摘目的:分析心脏外科术后肺部并发症的围手术期危险因素及其影响。方法:分析1995年1月~2002年2月间连续2084例正中切口右房-升主动脉体外循环心脏外科手术术前、术中及术后相关因素,观察它们在围手术期肺部并发症中的作用。结果:共有136例肺部并发症(6.5%)。肺部并发症的术前危险因素包括女性(相对危险度OR=1.49)、吸烟(OR=1.64)、慢性阻塞性肺部疾病(OR=2.36),术中危险因素包括应用冷心脏停搏液(OR=1.56),术后危险因素包括需要血管活性药物支持(OR=2.00)、2次开胸(OR=2.08)、主动脉内球囊反搏(OR=2.39)、胸腔积液(OR=2.63)、术后脑血管意外(OR=5.45)、膈神经损伤(OR=8.09)、以及术后肾功能衰竭需用肾透析(OR=12.87)。围手术期肺部并发症不是围手术期死亡的危险因素。结论:心脏外科术后多种围手术期危险因素增加术后肺部并发症的发生,特别是术后脑血管意外、膈神经损伤、以及肾功能衰竭需要肾透析对围手术期肺部并发症的发生影响最为明显。对此类患者需特别注意保护肺功能,以减少并发症的发生。围手术期肺部并发症不是围手术期死亡的危险因素。 | 邓勇志 孙宗全 Hugh S Paterson | 2007 | 临床心血管病杂志2007，23，8： | 5 |
| 8 | 双侧乳内动脉π型桥全动脉化冠状动脉旁路移植术显示文摘目的 研究 π型桥全动脉化心肌血运重建的临床应用。 方法 1994年 9月到 2 0 0 2年 8月对 2 2例患者根据冠状动脉病变解剖特点选用π型桥进行全动脉化心肌血运重建 ,即 3支血管病变合并对角支 /中间支中段病变时 ,采用由左侧乳内动脉小 Y型桥与前降支和对角支 /中间支吻合 ,与双侧乳内动脉 T型桥共同构成 π型桥。 结果本组无围术期死亡 ,无心肌梗死、脑血管意外和胸骨感染发生 ;1例患者术后二次开胸止血。随访 6 0 .7± 2 3.0个月 ,无心绞痛复发需要冠脉介入治疗或手术治疗者 ,也无冠心病导致的死亡发生。 结论 对 3支血管病变合并对角支 /中间支中段冠脉病变的患者 ,双侧乳内动脉 π型桥可以顺利完成全动脉化心肌血运重建 ,中期效果良好。 | 邓勇志 孙宗全 Hugh S Paterson | 2005 | 中国胸心血管外科临床杂志2005，12，1： | 4 |
| 9 | Factors related to quality of life in patients with cirrhosis and ascites: Relevance of serum sodium concentration and leg edema显示文摘 | Elsa Solà Hugh Watson Isabel Graupera Fanny Turón Rogelio Barreto Ezequiel Rodríguez Marco Pavesi Vicente Arroyo Mónica Guevara Pere Ginès | 2012 | Journal of Hepatology2012，，6： | 3 |
| 10 | 责任制医疗照护机构——美国的经验与教训显示文摘Hugh Alderwick与同事强调:英国国家健康体系(NHS)的政策制定者应实事求是地看待新型医疗保健模式带来的潜在收益。英格兰国家健康体系(NHS)决策圈都在谈论源自美国的一个新概念——责任制医疗照护机构(ACOs)。英格兰NHS和卫生部长认为ACO(s以及相关的责任制医疗体系)是改进NHS服务的重要途径。 | Hugh Alderwick Stephen M Shortell Adam D M Briggs Elliott S Fisher 周红霞(译) 肖月(校) | 2019 | 中国医院院长2019，0，12： | 2 |
| 11 | 视网膜病变、视网膜微血管异常与脑卒中、脑血管病的关系显示文摘视网膜循环异常可能与脑血管病有关。该研究基于英国的三民族人口的基础队列调查了视网膜微血管异常与脑卒中和亚临床脑梗死及脑白质病变之间的相关性。方法:纳入1185名受试者[年龄(68.8±6.1)岁,77%为男性]进行视网膜成像和脑磁共振成像。利用磁共振成像识别脑梗死和脑白质高信号,对视网膜病变进行分级,并测量视网膜血管参数。 | 刘莉 叶鹏 Hughes AD Falaschetti E Witt N Wijetunge S Thom SA Tillin T Aldington SJ Chaturvedi N | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 12 | Total Arterial Revascularization with Internal Mammary Artery or Radial Artery π Graft Configuration显示文摘To investigate the clinical use of π graft in total arterial revascularization and its outcomes, a retrospective analysis of 23 patients out of 1000 patients undergoing total arterial coronary bypass surgery with a π graft between September 1994 and December 2004 was performed. In the selected patients for the management of triple vessel disease with middle diagonal/intermediate ramus disease such that a skip with the left internal mammary artery (LIMA) or radial artery (RA), the main stem of π graft, to the left anterior descending coronary artery (LAD) will not work and the right internal mammary artery (RIMA) or right gastroepiploic artery (RGEA) cannot pick up the diagonal/intermediate ramus, hence the LAD and diagonal/intermediate ramus were grafted with a mini Y graft using the distal segment of LIMA, RIMA, RA or RGEA, together with the bilateral internal mammary artery (BIMA) or LIMA-RA T graft to compose π graft. Twenty-three patients (18 males, 5 females) underwent the π graft procedure. There were no deaths or episodes of myocardial infarction, stroke, and deep sternal wound infection. One patient required reopening for controlling bleeding. Until the end of 2004, during a mean follow-up of 81.0±28.4 months, no angina needing re-intervention or operative therapy or coronary related death occurred. In conclusion, in patients with specific coronary artery anatomy/stenosis, the BIMA (sometimes LIMA with RA or RGEA) π graft can be successfully performed for total arterial revascularization with good midterm outcomes. | 邓勇志 孙宗全 Hugh S PATERSON | 2005 | Journal of Huazhong University of Science and Technology(Medical Sciences)2005，25，5： | 2 |
| 13 | ST2可能并非心血管事件、心力衰竭和死亡有用的预测因子显示文摘研究人员假设可溶性ST2(soluble ST2,sST2)水平可识别出心血管疾病(cardiovascular disease,CVD)风险较高的人群,应将其纳入风险预测计算指标。ST2是炎症性细胞因子白细胞介素33的受体。sST2水平增加与急性心肌梗死患者和一般人群的心力衰竭及死亡相关。方法:研究人员测定FINRISK97前瞻性研究人群队列中的8444名男性和女性(25-74岁)的高敏sST2水平,应用Cox比例风险模型评估在15年的随访中,sST2对致命性或非致命性心力衰竭、CVD(冠状动脉性心脏病和脑卒中)、糖尿病和死亡情况的预测能力。研究者获取10年绝对风险识别和重新分类的统计数据, | 赵狄 叶鹏 Hughes MF Appelbaum S Havulinna AS Jagodzinski A Zeller T2 Kee F Blankenberg S Salomaa V | 2014 | 中华高血压杂志2014，22，8： | 2 |
| 14 | Esophageal Subepithelial Fibrosis in Children With Eosinophilic Esophagitis显示文摘 | Mirna Chehade Hugh A Sampson Raffaella A Morotti Margret S Magid | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，3： | 2 |
| 15 | Second order elastic deformation of solids显示文摘 | HUGHES D S KELLY J L | 1953 | Physical Review1953，92，5： | 1 |
| 16 | Plasma exchange for Guillain-Bane sysdrome(Cochrane Review)显示文摘 | Chevret S Hughes RA | 2001 | Cochrane Database Syst Rev2001，2，： | 1 |
| 17 | Coupling of flagellar gene expression to flagellar assembly in Salmonella enterica serovar typhimurium and Escherichia coli显示文摘 | CHILCOTT G S HUGHES K T | 2000 | Microbiol Mol Biol Rev2000，64，： | 1 |
| 18 | The aiding of a low-cost strapdown inertial measurement unit using vehicle model constraints for land vehicle applications显示文摘 | Dissanayake G Sukkarieh S Hugh D W | 2001 | IEEE Transactions on Robotics and Automation2001，17，5： | 1 |
| 19 | Acute and subacute effects of naturally occurring estrogens on luteinizing hormone secretion in the ovariectomised rat: part 2 显示文摘 | Hughes C L Chakinala M M Reece S G | 1991 | Reprod Toxicol1991，5，： | 1 |
| 20 | Climate in Medieval time显示文摘 | Bradley R S Hughes M K Diaz H F | 2003 | Science2003，302，： | 1 |
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