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1The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body.Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid 2019Genes & Diseases2019,6,3:15
2Efficient message passing interface(MPI) for parallel computing on clusters of workstations显示文摘Bruck J Dolev D Ho C H 1997Journal of Parallel and Distributed Computing1997,40,1:2
3Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K 2000Biochem Pharm2000,59,:1
4Characteristics of carbonaceous aerosol in Pearl River Delta Region, China during 2001 winter period 显示文摘CAO J J LEE S C HO K F 2003Atmos Environ2003,37,:1
5A general framework for global asymptotic stability analysis of delayed neural networks based on LMI approach 显示文摘Cao J Ho D W C 2005Chaos Solitons and Fractals2005,24,11:1
6Kinetics of pollutant sorption by biosorbents : review 显示文摘Ho Y S Ng J C McKay G 2000Sep Purif Methods2000,29,2:1
7Acquiring linear subspaces for Face recognition under variable lighting显示文摘LEE K C HO J KRIEGMAN D 2005IEEE Trans on Pattern Analysis and Machine Intelligence2005,27,5:1
8Study of a compact spiral-coil cooling and dehumidifying heat exchanger显示文摘HO J C 1996Applied Thermal Engineering1996,16,10:1
9Relay Auto-tuning in the Presence of Static Load Disturbance显示文摘Hang C C Astrom K J Ho W K 1993Automatica1993,29,2:1
10Resveratrol analog,3,4,5,4'-tetrahydroxystilbene,differentially induces proapoptotic p53/Bax gene expression and inhibits the growth of transformed cells but not their normal counterparts显示文摘Lu J B Ho C T Ghai G 2001Carcinogenesis2001,22,2:1
11Effects of F-doping on the photocatalytic activity and microstructures of nanocrystalline TiO2 powders显示文摘Yu J C Yu J Ho W 2002Chemistry of Materials2002,14,:1
12An integrated MRP and JIT framework显示文摘HO J C Chang Yihlong 2001Computers & lndutrial Engineering2001,41,2:1
13Impact of heavy metals on enzymatic activity of substrate and on composting worms Eiseniafetida 显示文摘Malley C Nair J Ho G 2006Bioresurce Technology2006,97,13:1
14The relative contribution of Chkl and Chk2 to Adriamycin induced checkpoint 显示文摘HO C C SIU W Y CHOW J P 2005Exp Cell Res2005,304,1:1
15Improvement of hybridyield by advanced backcross QTL analysis in elite maize显示文摘J C HO S R McCouch M E Smith 2002Theor Appl Genet2002,105,:1
16Modelling of springback in creepforming thick aluminum sheets 显示文摘Ho K C Lin J Dean T A 2004International Journal ofPlasticity2004,20,:1
17Preparation and photocatalytic behavior of MoS2 and WS2 nanocluster sensitized TiO2 显示文摘Ho W K Yu J C Lin J 2004Langmuir2004,20,14:1
18A qualitative and quanti- tative review of antecedents of counterproductive behav- ior in organizations 显示文摘Lau V S Au W T & Ho J C 2003Journal of Business and Psy- chology2003,18,1:1
19Light-induced super-hydrophilicity and photocatalytic activity of mesoporous Ti O2thin films显示文摘Yu J C Yu J G Ho W 2002Journal of Photochemistry and Photobiology A:Chemistry2002,148,1:1
20Current opinion on use of luteinizing hormone supplementation in assisted reproduction therapy:an Asian perspective显示文摘Wong PC Qiao J Ho C 2011Reprod Biomed Online2011,23,1:1
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