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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | The US national cholesterol education programe adult treatment panel Ⅲ(NCEPATP Ⅲ) prevalence of the meta bolic syndrome in a Chinese population显示文摘 | THOMAS G N HO S Y JANUS E D | 2005 | Diabetes Res Clin Pract2005，67，： | 1 |
| 3 | Screening of anabolic steroids in horse urine by liquid chromatography-tandem mass spectrometry显示文摘 | Yu N H Ho E N M Leung D K K | 2005 | J Pharm Biomed Anal2005，37，： | 1 |
| 4 | Reaction of ferrocene with polyaromatic molecules arene: bis ( cyclopentadienyl iron dications) molecular structure 显示文摘 | Ho E Y Hendrickson D N | 1974 | J Am Chem Soc1974，96，： | 1 |
| 5 | Heat shock produces periodic somitic disturbances in the zebrafish embryo 显示文摘 | Roy M N Prince V E Ho R K | 1999 | Mech Dev1999，85，12： | 1 |
| 6 | Reaction of ferrocene with polyaromatic molecules arene: bis (cyclopentadienyl iron dications) electronic structure显示文摘 | Ho E Y Hendrickson D N | 1975 | Inorg Chem1975，14，： | 1 |
| 7 | An apparently new enterovirus isolated from patients with disease of the central nervous system显示文摘 | Schmidt N Lennette E Ho H | | 0，，： | 1 |
| 8 | An effective architecture for learning and evolving flexible job-shop schedules显示文摘 | Ho N B Tay J C Lai E M K | 2007 | European Journal of Operational Research2007，179，2： | 1 |
| 9 | Debittering of skim milk hydrolysates by absorption for incorporation into acidic beverage显示文摘 | HELBIG N B HO L CHRISTY G E | 1980 | Journal of Food Science1980，45，： | 1 |
| 10 | An effective architecture for learning and evolving flexible job-shop schedules显示文摘 | Ho N B Tay J C Lai E M K | 2007 | European Journal of Operational Research2007，179，2： | 1 |
| 11 | An apparently new enterovims isolated- from patients with disease of the central nervous system显示文摘 | Schmidt N Lennette E Ho H | 1974 | J Infect Dis1974，129，： | 1 |
| 12 | Detection of anti-diabetics in equine plasma and urine by liquid chromatogram-tandem mass spectrometry显示文摘 | HO E N YIU K C WAN T S | 2004 | J Chromatogr B2004，811，1： | 1 |
| 13 | An apparently new entero virus isolated from patients with disease of the central nervous system显示文摘 | Sehmidt N J Lennette E H Ho H H | 1974 | J Infect Dis1974，129，30： | 1 |
| 14 | Improving rock phosphate availability through feeding, mixing and processing with composting manure 显示文摘 | Odongo N E Ho K H Choi H C | 2007 | Bioresource Technology2007，98，： | 1 |
| 15 | An effective architecture forlearning and evolving flexible job shop schedules显示文摘 | Ho N B Tay J C Lai E M K | 2007 | EuropeanJournal of Operational Research2007，179，2： | 1 |
| 16 | A capacitor-less CMOS active feedback low-dropout regulator with slew-rate enhancement for portable on-chip application显示文摘 | Ho E N Y MoK P K T | 2010 | IEEE Transactions on Circuits and Systems2010，57，2： | 1 |
| 17 | An effective architecture for learning and evolving flexible Job-Shop schedules显示文摘 | HO N B TAY J C LAI E M K | 2007 | European Journal of Operational Research2007，179，2： | 1 |
| 18 | An effective architecture for learning and evolving flexible job-shop schedules显示文摘 | Ho N B Tay J C Lai E M K | 2007 | European Journal of Operational Research2007，179，2： | 1 |
| 19 | Ru(Ⅱ) sensitizers bearing dianionic biazolate ancillaries:ligand synergy for high performance dye sensitized solar cells显示文摘 | Yeh H H Ho S T Chi Y Clifford J N Palomares E Liun S H Chou P T | | 0，，： | 1 |
| 20 | Low intracellular zinc induces oxidative DNA damage, disrupts p53,NFkappaB and AP1 binding and affects DNA repair in a rat glioma cell line显示文摘 | Ho E Ames B N | 2002 | Proceedings of the National Academy of Sciences of the United States of America2002，，16： | 1 |
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